SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000131
Gene Symbol:	F7
Description:	Homo sapiens coagulation factor VII (serum prothrombin conversion accelerator) (F7), transcript variant 1, mRNA.
Gene Location:	chr13(+):113760104-113774995
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.113119018C>A			COSN8587181		J30_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1825	cccagcaGCACTGGcctgt	0	UCCAGUGC	m7b	Created	no TS	0.000000	No effect
hsa-miR-4446-3p	cccagCAGCCCTGgcctgt	2	CAGGGCUG	m8a	Disrupted	-0.356000	-0.178000	No effect
hsa-miR-4685-5p	cccagcaGCCCTGGcctgt	1	CCCAGGGC	m7b	Disrupted	-0.292000	-0.146000	No effect
hsa-miR-512-3p	cccagCAGCACTggcctgt	0	AAGUGCUG	m7b	Created	no TS	0.000000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr13:g.113120488G>A			COSN6538556		ICGC_MB78		[central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1291	tgCAGGGCCAtcctgggca	0	UGGCCCUG	m8a	(m7a->m8a)	-0.162000	-0.380000	0.010000
hsa-miR-2392	tgcagggCCATCCTgggca	0	UAGGAUGG	m7b	Created	no TS	-0.050000	No effect
hsa-miR-328	tgcAGGGCCAtcctgggca	0	CUGGCCCU	m7b	(m6b->m7b)	no TS	-0.135000	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
113120483	rs3093258	G	G	hsa-miR-1205 hsa-miR-1291 hsa-miR-3173-5p hsa-miR-6775-3p hsa-miR-6799-3p	0	CCTGCAGggccgt cctgCAGGGCCgt cctGCAGGGCcgt cctgCAGGGCCgt cctGCAGGGCcgt	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.081 -0.162 -0.166 -0.162 -0.184
			A	hsa-miR-6511b-5p hsa-miR-6811-5p hsa-miR-6841-3p	0	CCTGCAAggccgt CCTGCAAggccgt ccTGCAAGGccgt	Created Created Created	N N N	-0.104 -0.101 -0.105

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