SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001214902
Gene Symbol:	ESR2
Description:	Homo sapiens estrogen receptor 2 (ER beta) (ESR2), transcript variant b, mRNA.
Gene Location:	chr14(-):64693750-64749793
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.64227168G>A			COSN1169977		HCC121T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.64227324C>T			COSN7024101		8067232		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3123	agacggATTCTCTtcagat	4	CAGAGAAU	m7b	Disrupted	-0.015000	no TS	3.090000
hsa-miR-3185	agacggattTTCTTCagat	0	AGAAGAAG	m6b	Created	no TS	-0.020000	-4.520000
hsa-miR-4668-3p	agacGGATTTTCttcagat	0	GAAAAUCC	m8a	Created	no TS	-0.032000	-8.890000
hsa-miR-4709-3p	agacggattCTCTTCAgat	3	UUGAAGAG	m7b	(m7b->m6b)	-0.131000	no TS	2.620000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.64227477G>T			COSN8864863		SNUH_G16_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3616-5p	ttCACTTCATtttccctct	2	AUGAAGUG	m8a	(m7b->m8a)	-0.180000	-0.207000	-2.230000
hsa-miR-3646	ttcacTTCATTTTccctct	0	AAAAUGAA	m8a	Created	no TS	0.053000	-0.550000
hsa-miR-3662	ttcactTCATTTTCcctct	0	GAAAAUGA	m8a	Created	no TS	0.027000	-0.910000
hsa-miR-4668-5p	ttcacttcaTTTTCCCTct	0	AGGGAAAA	m8a	(m7a->m8a)	no TS	-0.123000	-2.520000
hsa-miR-4738-3p	ttcacttCAGTTTCcctct	1	UGAAACUG	m7b	Disrupted	-0.090000	no TS	8.910000
hsa-miR-573	ttCACTTCAGtttccctct	2	CUGAAGUG	m8a	(m8a->m7b)	-0.171000	-0.198000	-1.460000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.64227477G>A			COSN8864864		SNUH_G45_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4738-3p	ttcacttCAGTTTCcctct	1	UGAAACUG	m7b	Disrupted	-0.090000	no TS	8.910000
hsa-miR-573	ttCACTTCAGtttccctct	2	CUGAAGUG	m8a	(m8a->m7b)	-0.171000	-0.302000	-1.620000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.64227831T>C			COSN5750226		HCC76T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
64227440	rs28440970	A	A	hsa-miR-4282 hsa-miR-944	2 1	aaaaatAATTTTA aaaAATAATTtta	Disrupted Disrupted	N N	0.071 -0.067
			G	hsa-miR-1250-3p hsa-miR-153-5p hsa-miR-4668-3p	1 1 2	aAAAATGAtttta AAAAATGAtttta aaaaatGATTTTA	Created Created Created	N N N	0.023 -0.058 -0.008
64227477	rs928554	A	G	hsa-miR-4738-3p	1	acttCAGTTTCcc	Created	N	-0.09
			A	hsa-miR-3616-5p hsa-miR-573	1 1	ACTTCAAtttccc ACTTCAAtttccc	Disrupted Disrupted	N N	-0.132 -0.131

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