SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000125
Gene Symbol: ESR1
Description: Homo sapiens estrogen receptor 1 (ESR1), transcript variant 1, mRNA.
Gene Location: chr6(+):152128813-152424408
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr6:g.152100144C>G COSN6308977 RK128_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-3p cgcattgccCTTTGGGggt
 0 GCCCAAAG m7b (m7b->m6c) 0.120000 no TS 2.670000
hsa-miR-4445-3p cgcaTTGCCGTttgggggt
 0 CACGGCAA m7b Created -0.211000 -0.270000 No effect
hsa-miR-548al cgcaTTGCCGTTtgggggt
 0 AACGGCAA m8a Created -0.180000 -0.248000 -3.040000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.152101919T>C COSN9497603 AOCS-091-3-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1251 cttcagttCTAGAGaagaa
 0 ACUCUAGC m6b Disrupted -0.025000 -0.017000 No effect
hsa-miR-1299 cttcagTTCCAGAgaagaa
 0 UUCUGGAA m7b Created no TS 0.040000 -0.050000
hsa-miR-3191-5p cttcagttCCAGAGAagaa
 10
 CUCUCUGG m7b Created 0.066000 0.004000 No effect
hsa-miR-326 cttcagttCCAGAGaagaa
 0 CCUCUGGG m6b Created no TS -0.005000 -0.010000
hsa-miR-330-5p cttcagttCCAGAGAagaa
 0 UCUCUGGG m7a Created no TS -0.005000 -1.210000
hsa-miR-4684-5p cttcagttcTAGAGAagaa
 2
 CUCUCUAC m6b Disrupted -0.030000 -0.076000 No effect
hsa-miR-517-5p cttcagtTCTAGAGaagaa
 0 CCUCUAGA m7b Disrupted -0.103000 -0.011000 0.490000
hsa-miR-518c-5p cttcagtTCCAGAGAagaa
 0 UCUCUGGA m8a Created no TS -0.113000 -3.380000
hsa-miR-518d-5p cttcagtTCTAGAGaagaa
 0 CUCUAGAG m7a Disrupted NA NA 0.160000
hsa-miR-518e-5p cttcagtTCTAGAGaagaa
 0 CUCUAGAG m7a Disrupted NA NA 0.450000
hsa-miR-518f-5p cttcagtTCTAGAGaagaa
 0 CUCUAGAG m7a Disrupted NA NA 0.300000
hsa-miR-519a-5p cttcagtTCTAGAGaagaa
 0 CUCUAGAG m7a Disrupted NA NA 0.450000
hsa-miR-519b-5p cttcagtTCTAGAGaagaa
 0 CUCUAGAG m7a Disrupted NA NA 0.450000
hsa-miR-519c-5p cttcagtTCTAGAGaagaa
 0 CUCUAGAG m7a Disrupted NA NA 0.450000
hsa-miR-520c-5p cttcagtTCTAGAGaagaa
 0 CUCUAGAG m7a Disrupted NA NA 0.160000
hsa-miR-522-5p cttcagtTCTAGAGaagaa
 0 CUCUAGAG m7a Disrupted NA NA 0.450000
hsa-miR-523-5p cttcagtTCTAGAGaagaa
 0 CUCUAGAG m7a Disrupted NA NA 0.450000
hsa-miR-526a cttcagtTCTAGAGaagaa
 0 CUCUAGAG m7a Disrupted NA NA 0.160000
hsa-miR-875-3p cttcagTTCCAGagaagaa
 0 CCUGGAAA m6b Created no TS 0.037000 -0.840000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.152101993T>C COSN14778636 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1285-3p gccatTGCCCAGcttgccg
 0 UCUGGGCA m7b Created no TS -0.060000 -0.500000
hsa-miR-3187-5p gccatTGCCCAGcttgccg
 0 CCUGGGCA m7b Created no TS -0.079000 -0.030000
hsa-miR-320e gccattgcCCAGCTTgccg
 0 AAAGCUGG m7b Created no TS 0.026000 -0.010000
hsa-miR-5189 gccatTGCCCAGcttgccg
 0 UCUGGGCA m7b Created no TS -0.088000 -3.410000
hsa-miR-612 gccatTGCCCAGCttgccg
 0 GCUGGGCA m8a Created no TS -0.060000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.152103185G>A COSN4953484 SS6003131 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-106a-5p acctcttttGCACTTTgaa
 0 AAAAGUGC m7b (m7b->m6c) -0.387000 -0.199000 No effect
hsa-miR-106b-5p acctcttttGCACTTTgaa
 0 UAAAGUGC m7b (m7b->m6c) -0.387000 -0.199000 0.030000
hsa-miR-130a-3p acctcttTTGCACTttgaa
 2
 CAGUGCAA m7b Disrupted -0.553000 -0.340000 0.230000
hsa-miR-130b-3p acctcttTTGCACTttgaa
 2
 CAGUGCAA m7b Disrupted -0.582000 -0.351000 0.020000
hsa-miR-17-5p acctcttttGCACTTTGaa
 0 CAAAGUGC m8a (m8a->m7b) -0.387000 -0.199000 No effect
hsa-miR-19a-3p acctctTTTGCACtttgaa
 17
 UGUGCAAA m7b Disrupted -0.364000 -0.160000 4.690000
hsa-miR-19b-3p acctctTTTGCACtttgaa
 17
 UGUGCAAA m7b Disrupted -0.364000 -0.160000 4.390000
hsa-miR-20a-5p acctcttttGCACTTTgaa
 0 UAAAGUGC m7b (m7b->m6c) -0.377000 -0.189000 0.010000
hsa-miR-20b-5p acctcttttGCACTTTGaa
 0 CAAAGUGC m8a (m8a->m7b) -0.377000 -0.189000 0.370000
hsa-miR-301a-3p acctcttTTGCACTttgaa
 2
 CAGUGCAA m7b Disrupted -0.589000 -0.358000 0.450000
hsa-miR-301b acctcttTTGCACTttgaa
 2
 CAGUGCAA m7b Disrupted -0.589000 -0.358000 2.430000
hsa-miR-3666 acctcttTTGCACTttgaa
 2
 CAGUGCAA m7b Disrupted -0.567000 -0.326000 0.010000
hsa-miR-4295 acctcttTTGCACTttgaa
 2
 CAGUGCAA m7b Disrupted -0.540000 -0.309000 0.020000
hsa-miR-454-3p acctcttTTGCACTttgaa
 2
 UAGUGCAA m7b Disrupted -0.567000 -0.326000 0.200000
hsa-miR-519a-3p acctctttTGCACTTTgaa
 2
 AAAGUGCA m8a Disrupted -0.282000 -0.028000 0.070000
hsa-miR-519b-3p acctctttTGCACTTTgaa
 2
 AAAGUGCA m8a Disrupted -0.282000 -0.028000 0.580000
hsa-miR-519c-3p acctctttTGCACTTTgaa
 2
 AAAGUGCA m8a Disrupted -0.282000 -0.028000 0.740000
hsa-miR-519d acctcttttGCACTTTGaa
 0 CAAAGUGC m8a (m8a->m7b) -0.384000 -0.177000 0.070000
hsa-miR-526b-3p acctcttttGCACTTTgaa
 0 GAAAGUGC m7b (m7b->m6c) -0.406000 -0.199000 No effect
hsa-miR-548aj-5p acctCTTTTGCActttgaa
 15
 UGCAAAAG m8a Disrupted -0.327000 -0.077000 0.190000
hsa-miR-548aw acctcTTTTGCACtttgaa
 17
 GUGCAAAA m8a Disrupted -0.213000 -0.130000 0.590000
hsa-miR-548g-5p acctCTTTTGCActttgaa
 15
 UGCAAAAG m8a Disrupted -0.327000 -0.077000 0.190000
hsa-miR-548x-5p acctCTTTTGCActttgaa
 15
 UGCAAAAG m8a Disrupted -0.327000 -0.077000 0.190000
hsa-miR-93-5p acctcttttGCACTTTGaa
 0 CAAAGUGC m8a (m8a->m7b) -0.377000 -0.189000 0.090000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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