SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_005236
Gene Symbol: ERCC4
Description: Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 4 (ERCC4), mRNA.
Gene Location: chr16(+):14014013-14046205
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr16:g.13948454T>C COSN7298814 8044436 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr16:g.13948478C>A COSN8485770 AOCS-155-3-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-26b-3p tacggtgGAACAGaagcca
 0 CCUGUUCU m6b Created no TS -0.094000 -0.020000
hsa-miR-3182 tacggtggaACAGAAGCca
 2
 GCUUCUGU m8a (m7b->m8a) -0.170000 -0.266000 -0.020000
hsa-miR-3663-5p tacggtgGACCAGaagcca
 4
 GCUGGUCU m6b Disrupted -0.135000 no TS No effect
hsa-miR-3692-3p tacgGTGGAACagaagcca
 0 GUUCCACA m7a Created NA NA -0.010000
hsa-miR-4652-3p tacggtggAACAGAAgcca
 0 GUUCUGUU m7b Created no TS 0.002000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr16:g.13948769G>C COSN7298815 8044436 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-28-3p tgttATCTAGTGcaacata
 2
 CACUAGAU m8a Disrupted -0.205000 -0.056000 -0.280000
hsa-miR-3129-5p tgttatCTACTGCaacata
 2
 GCAGUAGU m7a Created 0.028000 0.028000 -0.070000
hsa-miR-3935 tgtTATCTACtgcaacata
 0 UGUAGAUA m7b (m6b->m7b) no TS -0.141000 No effect
hsa-miR-936 tgttaTCTACTGcaacata
 2
 ACAGUAGA m7b Created 0.064000 -0.163000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr16:g.13949369C>T ICGC_AE77C542-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1207-5p ccactgcacCCCTGCCtgg
 0 UGGCAGGG m7b (m7b->m6c) -0.052 no TS No effect
hsa-miR-143-5p ccACTGCACCcctgcctgg
 0 GGUGCAGU m8a (m8a->m7a) 0.022 -0.005 -0.28
hsa-miR-1909-3p ccactgcaCCCCTGCctgg
 0 CGCAGGGG m7b Disrupted -0.243 -0.129 2.42
hsa-miR-342-5p ccactGCACCCCTgcctgg
 2
 AGGGGUGC m8a Disrupted -0.122 no TS 3.11
hsa-miR-4433-3p ccactgcACTCCTGcctgg
 0 ACAGGAGU m7b Created no TS 0.027 -0.02
hsa-miR-4664-5p ccactGCACCCCtgcctgg
 2
 UGGGGUGC m7b Disrupted -0.103 no TS 0.51
hsa-miR-4722-5p ccactgcaCTCCTGCCtgg
 0 GGCAGGAG m8a Created no TS -0.056 -0.95
hsa-miR-4763-3p ccactgcacCCCTGCCTgg
 0 AGGCAGGG m8a (m8a->m7b) -0.071 no TS 0.73

Mutation Mutation ID Sample Name Cancer Type
chr16:g.13949441A>C 9_136037 CRC-1-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-125a-3p cctaagcTCACCTGcctgt
 2
 ACAGGUGA m7b Disrupted -0.028 no TS 0.87
hsa-miR-1909-3p cctaagctCCCCTGCctgt
 2
 CGCAGGGG m7b Created -0.243 -0.375 -1.32
hsa-miR-3665 cctaagctCACCTGCctgt
 2
 AGCAGGUG m7b Disrupted -0.1 no TS 2.76
hsa-miR-4300 cctaAGCTCCCctgcctgt
 0 UGGGAGCU m7b Created no TS -0.121 -1.01
hsa-miR-4792 cctaaGCTCACCtgcctgt
 6
 CGGUGAGC m7b Disrupted -0.184 -0.04 5.19
hsa-miR-5591-5p cctaAGCTCCCctgcctgt
 0 UGGGAGCU m7b Created no TS -0.14 -14.78
hsa-miR-920 cctaAGCTCCCCtgcctgt
 0 GGGGAGCU m8a Created no TS -0.112 -0.44
hsa-miR-939 cctaaGCTCCCCtgcctgt
 6
 UGGGGAGC m7b Created no TS -0.16 No effect

Mutation Mutation ID Sample Name Cancer Type
chr16:g.13949619C>T 9_123434 CRC-9-Tumor Colorectal adenocarcinoma
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1279 ataaaAATATGAaagaaat
 2
 UCAUAUUG m7a Created -0.011 0.029 -0.23
hsa-miR-5007-3p ataaaaATATGAaagaaat
 2
 AUCAUAUG m6b Created -0.125 -0.088 No effect

Mutation Mutation ID Sample Name Cancer Type
chr16:g.13949987A>G COSN5758591 HX24T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-10a-5p ttgagACAGGGTctccctc
 0 UACCCUGU m7b Created no TS 0.012000 -0.070000
hsa-miR-10b-5p ttgagACAGGGTctccctc
 0 UACCCUGU m7b Created no TS 0.012000 -0.030000
hsa-miR-339-5p ttgaGACAGGGtctccctc
 0 UCCCUGUC m7b Created no TS -0.055000 -0.010000
hsa-miR-3664-5p ttgagACAGAGTctccctc
 0 AACUCUGU m7b Disrupted -0.308000 -0.366000 0.020000
hsa-miR-4421 ttgAGACAGGgtctccctc
 5
 ACCUGUCU m7b (m6b->m7b) -0.028000 -0.041000 No effect
hsa-miR-4522 ttgagaCAGAGTCtccctc
 1
 UGACUCUG m7b Disrupted 0.011000 no TS No effect
hsa-miR-4725-5p ttgagaCAGGGTCTccctc
 0 AGACCCUG m8a Created no TS -0.046000 -0.430000
hsa-miR-504 ttgagaCAGGGTCTccctc
 0 AGACCCUG m8a Created no TS -0.055000 No effect
hsa-miR-5699 ttgAGACAGGgtctccctc
 5
 UCCUGUCU m7b (m6b->m7b) -0.018000 0.025000 -0.040000

Mutation Mutation ID Sample Name Cancer Type
chr16:g.13950945T>G COSN9091733 8051716 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3133 atctGTTCTTTgctcttgt
 4
 UAAAGAAC m7b Disrupted 0.007000 -0.149000 0.020000
hsa-miR-4773 atCTGTTCTGtgctcttgt
 1
 CAGAACAG m8a (m7a->m8a) 0.010000 0.037000 -0.970000
hsa-miR-589-3p atcTGTTCTGtgctcttgt
 2
 UCAGAACA m7b (m6b->m7b) -0.234000 -0.151000 -0.510000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
13948442 rs117384292 A A hsa-miR-186-5p
4
 tatttcATTCTTT
 Disrupted
N
 0.002
G hsa-miR-3133
4
 tatttcGTTCTTT
 Created
N
 -0.103
13948831 rs3743538 T
T hsa-miR-3133
hsa-miR-4773
0 aatctGTTCTTTg
aatCTGTTCTttg
 Disrupted
Disrupted
N
N
 0.024
-0.123
13951550 rs114059834 A A hsa-miR-1279
hsa-miR-5701
2
2
 tagaCAATATGtc
taGACAATAtgtc
 Disrupted
Disrupted
N
N
 -0.011
-0.036
13951900 rs34103244 - T hsa-miR-3133
hsa-miR-4511
4
4
 aaGTTCTTTtttc
aAGTTCTTttttc
 Unknown
Unknown
N
N
 -0.01
-0.007
-
13952148 rs113403633 C C hsa-miR-3664-5p
5
 ttttaACAGAGTt
 Disrupted
N
 -0.283
T hsa-miR-618
7
 ttttaaTAGAGTT
 Created
N
 -0.229

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