SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001039753
Gene Symbol:	EML6
Description:	Homo sapiens echinoderm microtubule associated protein like 6 (EML6), mRNA.
Gene Location:	chr2(+):54952148-55199156
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.54970184G>A			COSN15304335		SNUH_G73_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-337-5p	ccaccAGCCGTTgggaaat	1	GAACGGCU	m7b	Disrupted	-0.210000	no TS	2.570000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.54970337G>C			COSN8315393		TCGA-D8-A1J8-01		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1266	tctgttCCTGAGactaaac	6	CCUCAGGG	m6b	Disrupted	-0.224000	-0.087000	4.270000
hsa-miR-3664-3p	tctgtTCCTGAGActaaac	6	UCUCAGGA	m8a	Disrupted	-0.364000	no TS	12.290000
hsa-miR-3915	tctgTTCCTCAgactaaac	0	UUGAGGAA	m7b	Created	no TS	-0.125000	-6.410000
hsa-miR-3928	tctGTTCCTCagactaaac	0	GGAGGAAC	m7b	(m6b->m7b)	no TS	-0.349000	-3.920000
hsa-miR-4474-5p	tctgttcctGAGACTAAac	0	UUAGUCUC	m8a	(m8a->m7b)	-0.472000	-0.214000	6.310000
hsa-miR-4518	tctgttCCTGAGactaaac	6	GCUCAGGG	m6b	Disrupted	-0.214000	-0.087000	0.850000
hsa-miR-873-5p	tctGTTCCTGagactaaac	4	GCAGGAAC	m7b	(m7b->m6b)	-0.319000	no TS	5.600000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.54970613G>T			COSN10003131		C0038T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4284	accaaaTGAGCCatgtata	16	GGGCUCAC	m6b	Disrupted	-0.125000	no TS	2.700000
hsa-miR-4802-3p	accaaatgaTCCATGTAta	15	UACAUGGA	m8a	(m7b->m8a)	-0.260000	-0.434000	-0.130000
hsa-miR-490-5p	accaaatgATCCATGtata	0	CCAUGGAU	m7b	Created	no TS	-0.181000	-1.720000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
54971328	rs143987142	A	A	hsa-miR-221-3p hsa-miR-222-3p hsa-miR-4802-3p hsa-miR-5690 hsa-miR-942-3p	2 2 2 6 2	ccATGTAGCtgac ccATGTAGCtgac CCATGTAgctgac ccatGTAGCTGAc CCATGTAgctgac	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.036 -0.036 -0.101 -0.153 -0.029
			C	hsa-miR-3683	2	ccATGTCGCtgac	Created	N	-0.186
54971524	rs180893154	A	A	hsa-miR-26a-1-3p hsa-miR-26a-2-3p hsa-miR-4474-5p hsa-miR-6731-3p	6 6 13 11	tAGAATAGActaa tAGAATAGActaa tagaatAGACTAA taGAATAGActaa	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.18 -0.19 -0.093 -0.048
			G	hsa-miR-4540 hsa-miR-6723-5p	13 13	tagaatGGACTAA tagaatGGACTAA	Created Created	N N	-0.147 -0.171
54971525	rs60351949	G	G	hsa-miR-26a-1-3p hsa-miR-26a-2-3p hsa-miR-4474-5p hsa-miR-6731-3p	6 6 13 11	AGAATAGActaac AGAATAGActaac agaatAGACTAAc aGAATAGActaac	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.18 -0.19 -0.093 -0.048
			C	hsa-miR-223-5p hsa-miR-3591-5p hsa-miR-4280 hsa-miR-630	3 13 13 6	agAATACACtaac agaatACACTAAc agaaTACACTAac AGAATACActaac	Created Created Created Created	N N N N	-0.118 -0.144 -0.1 -0.191

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