SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001178131
Gene Symbol: EGF
Description: Homo sapiens epidermal growth factor (EGF), transcript variant 2, mRNA.
Gene Location: chr4(+):110834039-110934118
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr4:g.110011628A>C COSN9584333 AOCS-125-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-139-3p cttttaagcCGTCTCactg
 0 GGAGACGC m6b Created no TS -0.184000 -9.830000
hsa-miR-3672 cttttaagcAGTCTCActg
 2
 AUGAGACU m7b (m7b->m6c) -0.175000 no TS -0.060000
hsa-miR-4463 cttttaagCAGTCTCactg
 0 GAGACUGG m7a Disrupted NA NA -2.410000
hsa-miR-873-3p cttttaagCAGTCTCactg
 2
 GGAGACUG m7b Disrupted -0.314000 no TS -0.330000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.110011823G>T COSN15358316 0078_CRUK_PC_0078_T1_DNA [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4724-5p actggtttGTTCAGTTaca
 0 AACUGAAC m8a Created no TS -0.215000 -0.010000
hsa-miR-495 actgGTTTGTTcagttaca
 0 AAACAAAC m7b Created no TS -0.017000 No effect
hsa-miR-5688 actgGTTTGTTcagttaca
 0 UAACAAAC m7b Created no TS -0.017000 0.040000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.110012381T>C COSN1285218 HX12T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3148 tttttTTTTTCCggagaga
 1
 UGGAAAAA m7b Disrupted 0.016000 0.028000 No effect
hsa-miR-4497 ttttttttTCCCGGAGaga
 0 CUCCGGGA m8a Created no TS -0.281000 -2.920000
hsa-miR-4668-5p tttttTTTTCCCggagaga
 0 AGGGAAAA m7b Created -0.087000 -0.211000 -2.730000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.110012383C>G COSN1979565 RK005_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3148 tttTTTTTCCggagagagg
 1
 UGGAAAAA m7b (m7b->m6b) 0.016000 no TS 0.010000
hsa-miR-3148 tttTTTTTCCggagagagg
 1
 UGGAAAAA m7b (m7b->m6b) 0.016000 no TS 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.110012498C>A COSN7723866 8034061 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3664-5p tcagcctcCAGAGTaacta
 0 AACUCUGU m6b Created no TS -0.051000 -0.010000
hsa-miR-4443 tcaGCCTCCAgagtaacta
 0 UUGGAGGC m7b (m6b->m7b) no TS -0.156000 -8.810000
hsa-miR-4714-5p tcagcctcCAGAGTaacta
 0 AACUCUGA m6b Created no TS -0.062000 -0.410000
hsa-miR-514a-5p tcagcctCCAGAGTAacta
 0 UACUCUGG m8a Created no TS -0.271000 -0.220000
hsa-miR-516b-5p tcagcCTCCAGAgtaacta
 0 AUCUGGAG m7b Created no TS -0.066000 -1.690000
hsa-miR-518c-5p tcagccTCCAGAGtaacta
 0 UCUCUGGA m7b Created no TS -0.095000 -0.820000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.110012729T>A COSN4823922 tumor_4133511 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4282 ttaaaaAAATTTTttaatc
 1
 UAAAAUUU m7b Disrupted -0.003000 -0.003000 0.230000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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