SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001178130
Gene Symbol:	EGF
Description:	Homo sapiens epidermal growth factor (EGF), transcript variant 2, mRNA.
Gene Location:	chr4(+):110834039-110934118
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.110011628A>C			COSN9584333		AOCS-125-1-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-139-3p	cttttaagcCGTCTCactg	0	GGAGACGC	m6b	Created	no TS	-0.184000	-9.830000
hsa-miR-3672	cttttaagcAGTCTCActg	2	AUGAGACU	m7b	(m7b->m6c)	-0.175000	no TS	-0.060000
hsa-miR-4463	cttttaagCAGTCTCactg	0	GAGACUGG	m7a	Disrupted	NA	NA	-2.410000
hsa-miR-873-3p	cttttaagCAGTCTCactg	2	GGAGACUG	m7b	Disrupted	-0.314000	no TS	-0.330000

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.110011823G>T			COSN15358316		0078_CRUK_PC_0078_T1_DNA		[prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4724-5p	actggtttGTTCAGTTaca	0	AACUGAAC	m8a	Created	no TS	-0.215000	-0.010000
hsa-miR-495	actgGTTTGTTcagttaca	0	AAACAAAC	m7b	Created	no TS	-0.017000	No effect
hsa-miR-5688	actgGTTTGTTcagttaca	0	UAACAAAC	m7b	Created	no TS	-0.017000	0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.110012381T>C			COSN1285218		HX12T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3148	tttttTTTTTCCggagaga	1	UGGAAAAA	m7b	Disrupted	0.016000	0.028000	No effect
hsa-miR-4497	ttttttttTCCCGGAGaga	0	CUCCGGGA	m8a	Created	no TS	-0.281000	-2.920000
hsa-miR-4668-5p	tttttTTTTCCCggagaga	0	AGGGAAAA	m7b	Created	-0.087000	-0.211000	-2.730000

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.110012383C>G			COSN1979565		RK005_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3148	tttTTTTTCCggagagagg	1	UGGAAAAA	m7b	(m7b->m6b)	0.016000	no TS	0.010000
hsa-miR-3148	tttTTTTTCCggagagagg	1	UGGAAAAA	m7b	(m7b->m6b)	0.016000	no TS	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.110012498C>A			COSN7723866		8034061		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3664-5p	tcagcctcCAGAGTaacta	0	AACUCUGU	m6b	Created	no TS	-0.051000	-0.010000
hsa-miR-4443	tcaGCCTCCAgagtaacta	0	UUGGAGGC	m7b	(m6b->m7b)	no TS	-0.156000	-8.810000
hsa-miR-4714-5p	tcagcctcCAGAGTaacta	0	AACUCUGA	m6b	Created	no TS	-0.062000	-0.410000
hsa-miR-514a-5p	tcagcctCCAGAGTAacta	0	UACUCUGG	m8a	Created	no TS	-0.271000	-0.220000
hsa-miR-516b-5p	tcagcCTCCAGAgtaacta	0	AUCUGGAG	m7b	Created	no TS	-0.066000	-1.690000
hsa-miR-518c-5p	tcagccTCCAGAGtaacta	0	UCUCUGGA	m7b	Created	no TS	-0.095000	-0.820000

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.110012729T>A			COSN4823922		tumor_4133511		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4282	ttaaaaAAATTTTttaatc	1	UAAAAUUU	m7b	Disrupted	-0.003000	-0.003000	0.230000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
110011555	rs56067801	A	A	hsa-miR-4752 hsa-miR-5186 hsa-miR-6833-5p	2 3 2	TCCACAAtctcta tccaCAATCTCta TCCACAAtctcta	Disrupted Disrupted Disrupted	N N N	-0.147 -0.181 -0.166
			G	hsa-miR-4318 hsa-miR-7114-5p hsa-miR-873-3p	3 2 3	tCCACAGTctcta TCCACAGtctcta tccaCAGTCTCta	Created Created Created	N N N	-0.22 -0.207 -0.205
110011737	rs112146341	C	C	hsa-miR-3136-5p hsa-miR-4439 hsa-miR-5002-3p hsa-miR-93-3p hsa-miR-943	2 2 2 2 2	cttcagCAGTCAA cttcagCAGTCAA cttcaGCAGTCAa ctTCAGCAGtcaa cttcagCAGTCAA	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.144 -0.14 -0.195 -0.241 -0.143
			T	hsa-miR-4724-5p	3	cTTCAGTAgtcaa	Created	N	-0.068
110012384	rs112147938	G	G	hsa-miR-6845-3p	1	ttttccGGAGAGA	Disrupted	N	-0.078
			A	hsa-miR-1299 hsa-miR-3148 hsa-miR-3191-5p hsa-miR-326 hsa-miR-330-5p hsa-miR-518c-5p hsa-miR-6124 hsa-miR-6128 hsa-miR-6764-3p hsa-miR-6817-3p hsa-miR-6824-3p hsa-miR-6873-3p hsa-miR-7110-3p hsa-miR-875-3p	1 1 1 1 1 1 1 1 1 1 1 1 1 1	ttTTCCAGAgaga TTTTCCAgagaga ttttCCAGAGAga ttttCCAGAGAga ttttCCAGAGAga tttTCCAGAGAga TTTTCCAgagaga ttTTCCAGAgaga ttttCCAGAGAga ttttcCAGAGAGA ttttCCAGAGAga ttttccAGAGAGA ttttccAGAGAGA tTTTCCAGAgaga	Created Created Created Created Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N N N N N	-0.13 -0.038 -0.142 -0.086 -0.086 -0.289 0.016 -0.071 -0.102 -0.165 -0.098 -0.026 -0.101 -0.149

Genome Browser