SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_003583 |
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Gene Symbol: | DYRK2 |
Description: | Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2), transcript variant 1, mRNA. |
Gene Location: | chr12(+):68042511-68056444 |
Browse Associations |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr12:g.67659020G>A | COSN1582136 | RK126_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-147a |
gactgCCACACAtttacag |
0 | GUGUGUGG | m7b | Created | no TS | -0.171000 | No effect | |
hsa-miR-644a |
gactGCCACACatttacag |
0 | AGUGUGGC | m7b | Created | no TS | -0.436000 | No effect | |
hsa-miR-147a |
gactgCCACACAtttacag |
0 | GUGUGUGG | m7b | Created | no TS | -0.171 | No effect | |
hsa-miR-644a |
gactGCCACACatttacag |
0 | AGUGUGGC | m7b | Created | no TS | -0.436 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr12:g.67660302G>A | COSN9754277 | C0004T | [kidney][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1304-3p |
tggtcccCAGTGAGgccaa |
12 |
UCUCACUG | m7b | Disrupted | 0.112000 | no TS |
1.560000 |
|
hsa-miR-450a-3p |
tggTCCCCAATgaggccaa |
6 |
AUUGGGGA | m8a | Created | -0.209000 | -0.170000 |
-0.100000 |
|
hsa-miR-4667-5p |
tggTCCCCAGTgaggccaa |
0 | ACUGGGGA | m8a | Disrupted | -0.167000 | -0.203000 |
0.030000 |
|
hsa-miR-4700-5p |
tggTCCCCAGtgaggccaa |
0 | UCUGGGGA | m7b | (m7b->m6b) | -0.188000 | -0.215000 |
0.040000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr12:g.67661030A>G | COSN8586572 | J10_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3617 |
tttgagacTGTCTTTattt |
19 |
AAAGACAU | m7a | Created | -0.004000 | -0.004000 | No effect | |
hsa-miR-4474-5p |
tttGAGACTAtctttattt |
1 |
UUAGUCUC | m7b | (m7b->m6b) | -0.100000 | no TS |
0.380000 |
|
hsa-miR-4662a-3p |
tttgagaCTATCTTTattt |
16 |
AAAGAUAG | m8a | Disrupted | 0.062000 | 0.076000 |
0.010000 |
|
hsa-miR-548u |
tttgagactGTCTTTattt |
0 | CAAAGACU | m6b | Created | no TS | 0.069000 |
-0.100000 |
|
hsa-miR-641 |
tttgagacTGTCTTTattt |
19 |
AAAGACAU | m7a | Created | -0.004000 | -0.004000 |
0.160000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr12:g.67661179C>A | COSN9473898 | AOCS-130-1-0 | [ovary][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-34a-3p |
atagaGCTGATTtaataaa |
2 |
CAAUCAGC | m7b | Created | -0.028000 | -0.123000 | No effect | |
hsa-miR-4422 |
atagagcTGCTTTaataaa |
0 | AAAAGCAU | m6b | Disrupted | -0.111000 | -0.177000 | No effect | |
hsa-miR-4660 |
ataGAGCTGCtttaataaa |
6 |
UGCAGCUC | m7b | (m7b->m6b) | -0.283000 | -0.108000 |
0.240000 |
|
hsa-miR-551b-5p |
atagagcTGATTTaataaa |
11 |
GAAAUCAA | m6b | Created | 0.176000 | 0.303000 | No effect | |
hsa-miR-646 |
atagAGCTGCTTtaataaa |
7 |
AAGCAGCU | m8a | Disrupted | -0.077000 | no TS | No effect | |
hsa-miR-9-3p |
atagagctGCTTTAataaa |
0 | AUAAAGCU | m6b | Disrupted | -0.020000 | -0.088000 |
0.190000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr12:g.67662277A>G | COSN7618556 | PCSI_0083_Pa_P_526 | [pancreas][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-4708-5p |
ggggcttgtGCATCTCTct |
0 | AGAGAUGC | m8a | (m7b->m8a) | 0.053000 | -0.121000 |
-3.250000 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
67661158 | rs186367036 | C | C |
hsa-miR-1273f hsa-miR-143-3p hsa-miR-4663 hsa-miR-4708-5p hsa-miR-4728-3p hsa-miR-4770 hsa-miR-6088 hsa-miR-7160-5p hsa-miR-8077 |
0 |
aCATCTCAgcatt aCATCTCAgcatt acatCTCAGCAtt aCATCTCAgcatt acatcTCAGCATt aCATCTCAgcatt aCATCTCAgcatt acatCTCAGCAtt acatCTCAGCAtt |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N |
0.072 0.065 -0.028 0.053 0.004 0.062 0.072 -0.008 -0.024 |
G |
hsa-miR-1245b-3p hsa-miR-3934-3p hsa-miR-4330 |
0 |
aCATCTGAgcatt acatCTGAGCAtt acATCTGAGcatt |
Created Created Created |
N N N |
0.069 -0.029 0.041 |