SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000108
Gene Symbol: DLD
Description: Homo sapiens dihydrolipoamide dehydrogenase (DLD), mRNA.
Gene Location: chr7(+):107531585-107561643
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr7:g.107919277A>T COSN15330107 SNUH_G76_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1277-5p attatATATATTTttttct
0 AAAUAUAU m8a Disrupted 0.000000 0.000000 0.020000
hsa-miR-5011-5p atTATATATAtttttttct
0 UAUAUAUA m8a (m8a->m7a) 0.000000 0.000000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.107919288A>G COSN1340253 BN22T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-205-3p ttttttCTGAAATttcctg
11
GAUUUCAG m7b Disrupted -0.252000 -0.096000 0.100000
hsa-miR-3180-5p tttttTCTGGAAtttcctg
0 CUUCCAGA m7b Created no TS -0.221000 -0.030000
hsa-miR-513a-3p ttttttctGAAATTTcctg
8
UAAAUUUC m7b Disrupted 0.296000 0.301000 No effect
hsa-miR-513c-3p ttttttctGAAATTTcctg
8
UAAAUUUC m7b Disrupted 0.296000 0.301000 No effect
hsa-miR-520a-5p tttttTCTGGAatttcctg
0 CUCCAGAG m6b Created no TS -0.176000 -10.860000
hsa-miR-525-5p tttttTCTGGAatttcctg
0 CUCCAGAG m6b Created no TS -0.169000 -4.170000
hsa-miR-205-3p ttttttCTGAAATttcctg
11
GAUUUCAG m7b Disrupted -0.252000 -0.096000 0.100000
hsa-miR-3180-5p tttttTCTGGAAtttcctg
0 CUUCCAGA m7b Created no TS -0.221000 -0.030000
hsa-miR-513a-3p ttttttctGAAATTTcctg
8
UAAAUUUC m7b Disrupted 0.296000 0.301000 No effect
hsa-miR-513c-3p ttttttctGAAATTTcctg
8
UAAAUUUC m7b Disrupted 0.296000 0.301000 No effect
hsa-miR-520a-5p tttttTCTGGAatttcctg
0 CUCCAGAG m6b Created no TS -0.176000 -10.860000
hsa-miR-525-5p tttttTCTGGAatttcctg
0 CUCCAGAG m6b Created no TS -0.169000 -4.170000
hsa-miR-205-3p ttttttCTGAAATttcctg
11
GAUUUCAG m7b Disrupted -0.252000 -0.096000 0.100000
hsa-miR-3180-5p tttttTCTGGAAtttcctg
0 CUUCCAGA m7b Created no TS -0.221000 -0.030000
hsa-miR-513a-3p ttttttctGAAATTTcctg
8
UAAAUUUC m7b Disrupted 0.296000 0.301000 No effect
hsa-miR-513c-3p ttttttctGAAATTTcctg
8
UAAAUUUC m7b Disrupted 0.296000 0.301000 No effect
hsa-miR-520a-5p tttttTCTGGAatttcctg
0 CUCCAGAG m6b Created no TS -0.176000 -10.860000
hsa-miR-525-5p tttttTCTGGAatttcctg
0 CUCCAGAG m6b Created no TS -0.169000 -4.170000
hsa-miR-205-3p ttttttCTGAAATttcctg
11
GAUUUCAG m7b Disrupted -0.252 -0.096 0.1
hsa-miR-3180-5p tttttTCTGGAAtttcctg
0 CUUCCAGA m7b Created no TS -0.221 -0.03
hsa-miR-513a-3p ttttttctGAAATTTcctg
0 UAAAUUUC m7b Disrupted 0.296 0.301 No effect
hsa-miR-513c-3p ttttttctGAAATTTcctg
0 UAAAUUUC m7b Disrupted 0.296 0.301 No effect
hsa-miR-520a-5p tttttTCTGGAatttcctg
0 CUCCAGAG m6b Created no TS -0.176 -10.86
hsa-miR-525-5p tttttTCTGGAatttcctg
0 CUCCAGAG m6b Created no TS -0.169 -4.17

Mutation Mutation ID Sample Name Cancer Type
chr7:g.107919505A>G COSN9819235 AOCS-091-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5091 tcctggaatGTCTCCGTca
0 ACGGAGAC m8a (m7b->m8a) no TS -0.343000 -4.000000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.107919902C>G COSN8403777 tumor_4163639 [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1224-3p actcaaatAGGTGGGcatt
0 CCCCACCU m7b Created no TS -0.230000 -7.100000
hsa-miR-662 actcaaatACGTGGGcatt
0 UCCCACGU m7b Disrupted -0.269000 no TS 7.150000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.107920193T>A COSN2190860 RK189_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-141-3p tctttaatCAGTGTTttcc
0 UAACACUG m7b Created no TS -0.119000 -0.770000
hsa-miR-200a-3p tctttaatCAGTGTTttcc
0 UAACACUG m7b Created no TS -0.091000 -0.160000
hsa-miR-3920 tcttTAATCAGTgttttcc
0 ACUGAUUA m8a Created no TS -0.060000 -6.870000
hsa-miR-141-3p tctttaatCAGTGTTttcc
0 UAACACUG m7b Created no TS -0.119000 -0.770000
hsa-miR-200a-3p tctttaatCAGTGTTttcc
0 UAACACUG m7b Created no TS -0.091000 -0.160000
hsa-miR-3920 tcttTAATCAGTgttttcc
0 ACUGAUUA m8a Created no TS -0.060000 -6.870000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
107919277 rs8721 A A hsa-miR-1277-5p
hsa-miR-190a-3p
hsa-miR-5011-5p
2
2
2
atATATATTtttt
ATATATAtttttt
aTATATATttttt
Disrupted
Disrupted
Disrupted
N
N
N
No Change
No Change
No Change
107919279 rs145589369 T T hsa-miR-1277-5p
2
ATATATTtttttc
Disrupted
N
0.155
A hsa-miR-190a-3p
hsa-miR-5011-5p
2
2
ATATATAtttttc
aTATATATttttc
Created
Created
N
N
No Change
-0.13
107919287 rs17154615 G G hsa-miR-205-3p
hsa-miR-3606-3p
hsa-miR-3942-3p
hsa-miR-513a-3p
hsa-miR-513c-3p
11
8
10
8
8
ttttCTGAAATtt
ttttctGAAATTT
tttTCTGAAAttt
ttttctGAAATTT
ttttctGAAATTT
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
-0.156
-0.033
-0.126
-0.005
-0.005
T hsa-miR-3653
hsa-miR-3658
10
10
ttTTCTTAAattt
ttTTCTTAAAttt
Created
Created
N
N
-0.063
-0.237
107919907 rs57801571 G G hsa-miR-365a-3p
hsa-miR-365b-3p
hsa-miR-662
1
1
2
acgtGGGCATTca
acgtGGGCATTca
ACGTGGGcattca
Disrupted
Disrupted
Disrupted
N
N
N
-0.179
-0.179
-0.269

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