SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_173602
Gene Symbol:	DIP2B
Description:	Homo sapiens DIP2 disco-interacting protein 2 homolog B (Drosophila) (DIP2B), mRNA.
Gene Location:	chr12(+):50898767-51142450
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.50744962C>A			COSN9751225		C0051T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1255a	tcttcatCTCATCCTgtgg	3	AGGAUGAG	m8a	Disrupted	-0.427000	-0.154000	0.720000
hsa-miR-1255b-5p	tcttcatCTCATCCtgtgg	3	CGGAUGAG	m7b	Disrupted	-0.427000	-0.154000	1.510000
hsa-miR-1273f	tcttCATCTCatcctgtgg	0	GGAGAUGG	m6b	Disrupted	-0.068000	0.032000	0.250000
hsa-miR-143-3p	tctTCATCTCAtcctgtgg	0	UGAGAUGA	m8a	Disrupted	-0.336000	0.025000	1.890000
hsa-miR-3159	tcttcatcTAATCCTgtgg	5	UAGGAUUA	m7b	Created	0.092000	-0.023000	-0.010000
hsa-miR-4708-5p	tcttCATCTCatcctgtgg	0	AGAGAUGC	m6b	Disrupted	-0.091000	0.017000	1.550000
hsa-miR-4770	tctTCATCTCAtcctgtgg	0	UGAGAUGA	m8a	Disrupted	-0.328000	0.022000	2.450000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.50745158T>G			COSN8586274		2734_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.50746303T>G			COSN4899000		CPCG_0006_Pr_P_F0		[prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3925-5p	atgGTTCTCTTtgacccac	2	AAGAGAAC	m8a	Disrupted	0.022000	-0.024000	No effect
hsa-miR-4311	atggtTCTCTTTgacccac	10	GAAAGAGA	m7b	Disrupted	0.190000	0.081000	No effect
hsa-miR-583	atggttCTCTTTGacccac	6	CAAAGAGG	m7a	Disrupted	-0.028000	-0.028000	No effect
hsa-miR-3925-5p	atgGTTCTCTTtgacccac	15	AAGAGAAC	m8a	Disrupted	0.022	-0.024	No effect
hsa-miR-4311	atggtTCTCTTTgacccac	15	GAAAGAGA	m7b	Disrupted	0.19	0.081	No effect
hsa-miR-583	atggttCTCTTTGacccac	0	CAAAGAGG	m7a	Disrupted	-0.028	-0.028	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.50746470C>T			COSN7616632		ASHPC_0017_Pa_P		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.50747110A>G			COSN5323783		RK085_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1273d	ttattaATGGGTTatttta	0	GAACCCAU	m7b	Created	no TS	-0.132000	-0.010000
hsa-miR-660-5p	ttattAATGGGTtatttta	0	UACCCAUU	m7b	Created	no TS	-0.135000	-0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.50748504A>G			COSN1575783		RK062_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4452	tcaAATTCAAactacagta	2	UUGAAUUC	m7a	(m7a->m6a)	-0.029000	-0.011000	0.070000
hsa-miR-4680-3p	tcaAATTCAGActacagta	0	UCUGAAUU	m8a	Created	0.152000	-0.041000	-0.010000
hsa-miR-5187-3p	tcaaATTCAGactacagta	0	ACUGAAUC	m6b	Created	no TS	-0.050000	-0.160000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
50744957	rs116928962	C	C	hsa-miR-1273f hsa-miR-143-3p hsa-miR-3185 hsa-miR-4708-5p hsa-miR-4770 hsa-miR-6088	17 17 3 17 17 17	attcttCATCTCA attctTCATCTCA aTTCTTCAtctca attcttCATCTCA attctTCATCTCA attctTCATCTCA	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.1 -0.361 -0.055 -0.108 -0.35 -0.308
			T	hsa-miR-186-5p hsa-miR-3133 hsa-miR-577	3 3 17	ATTCTTTAtctca aTTCTTTAtctca attcTTTATCTca	Created Created Created	N N N	-0.102 No Change -0.054

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