SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001134445
Gene Symbol: DDAH1
Description: Homo sapiens dimethylarginine dimethylaminohydrolase 1 (DDAH1), transcript variant 2, mRNA.
Gene Location: chr1(-):85784167-86044046
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr1:g.85318754G>C COSN8309202 TCGA-BH-A0B6-01 [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-452-5p taaggtAAACAGTTgcatg
 0 AACUGUUU m8a Created no TS -0.077000 -0.110000
hsa-miR-4676-3p taaggtAAACAGTtgcatg
 0 CACUGUUU m7b Created no TS -0.114000 -0.110000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.85320483C>T COSN6471348 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-224-5p acccTGACTTaccgtattt
 0 CAAGUCAC m6b Created no TS 0.039000 -0.730000
hsa-miR-5702 accCTGACTCAccgtattt
 0 UGAGUCAG m8a Disrupted -0.074000 no TS 2.520000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.85320745A>C COSN6048628 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2682-3p taactacacAGAGGCacat
 9
 CGCCUCUU m6b Disrupted -0.081000 no TS 5.870000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.85321218A>C COSN8512225 AOCS-166-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3194-3p aagataCAGAGCTaatgaa
 0 AGCUCUGC m7a Disrupted NA NA 0.010000
hsa-miR-4999-5p aagATACAGCgctaatgaa
 0 UGCUGUAU m7b (m6c->m7b) no TS -0.206000 -0.520000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.85321428C>T COSN10055190 C0021T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1202 cccggttGCTGGCAagacc
 0 GUGCCAGC m7b Created no TS -0.455000 -5.800000
hsa-miR-3194-5p cccggttGCTGGCaagacc
 3
 GGCCAGCC m6b Created -0.257000 -0.435000 -1.510000
hsa-miR-3972 cccggttGCTGGCAagacc
 0 CUGCCAGC m7b Created no TS -0.403000 -0.120000
hsa-miR-4776-3p cccggttgcTGGCAAGacc
 10
 CUUGCCAU m7a (m6a->m7a) -0.014000 -0.014000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.85321435C>G COSN15322852 SNUH_G76_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4532 agtccCCCCGGGttgccgg
 0 CCCCGGGG m7b Created no TS 0.000000 No effect
hsa-miR-4655-5p agtcccCCCCGGTtgccgg
 1
 CACCGGGG m7b Disrupted 0.000000 no TS No effect
hsa-miR-4532 agtccCCCCGGGttgccgg
 0 CCCCGGGG m7b Created no TS 0.000000 No effect
hsa-miR-4655-5p agtcccCCCCGGTtgccgg
 1
 CACCGGGG m7b Disrupted 0.000000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.85321441C>A COSN15323990 SNUH_G76_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4522 ctgCAGAGTCccccccggt
 7
 UGACUCUG m7b (m7b->m6c) 0.000000 no TS No effect
hsa-miR-4652-5p ctgcagAGTCCCCcccggt
 1
 AGGGGACU m7b Disrupted 0.000000 no TS No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
85320483 rs3813600 C C hsa-miR-433-5p
hsa-miR-5702
hsa-miR-937-5p
0 ctgacTCACCGTA
CTGACTCAccgta
cTGACTCAccgta
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.272
-0.074
0.005
T hsa-miR-224-5p
10
 cTGACTTAccgta
 Created
N
 0.039
85321435 rs3087894 C C hsa-miR-4655-5p
1
 cccCCCCGGTtgc
 Disrupted
N
 No Change
G hsa-miR-4532
1
 ccCCCCGGGttgc
 Created
N
 No Change
85321437 rs199952327 C C hsa-miR-4655-5p
hsa-miR-6795-5p
hsa-miR-6887-5p
1
1
1
 gtcccCCCCGGTt
gTCCCCCCcggtt
gTCCCCCCcggtt
 Disrupted
Disrupted
Disrupted
N
N
N
 No Change
No Change
No Change
G hsa-miR-1908-5p
hsa-miR-4706
hsa-miR-4749-5p
hsa-miR-663a
hsa-miR-6787-5p
1
1
1
1
1
 gtCCCCGCCggtt
gTCCCCGCcggtt
gTCCCCGCcggtt
gtCCCCGCCggtt
gtCCCCGCCggtt
 Created
Created
Created
Created
Created
N
N
N
N
N
 No Change
No Change
No Change
No Change
No Change
85321441 rs116870917 C C hsa-miR-4522
hsa-miR-4652-5p
hsa-miR-6795-5p
hsa-miR-6887-5p
7
1
15
15
 CAGAGTCcccccc
cagAGTCCCCccc
cagagTCCCCCCc
cagagTCCCCCCc
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 No Change
No Change
No Change
No Change
A hsa-miR-3664-5p
hsa-miR-4714-5p
hsa-miR-514a-5p
hsa-miR-6835-5p
7
7
7
15
 CAGAGTAcccccc
CAGAGTAcccccc
CAGAGTAcccccc
cagagTACCCCCc
 Created
Created
Created
Created
N
N
N
N
 No Change
No Change
No Change
No Change

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