SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001198855
Gene Symbol:	CYP2C8
Description:	Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8), transcript variant 1, mRNA.
Gene Location:	chr10(-):96796528-96829254
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.95037104C>T			COSN163713		GC8_T		[stomach][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-214-3p	tctggCTGCTGatctgcta	0	ACAGCAGG	m6b	Created	no TS	-0.120000	-6.600000
hsa-miR-424-5p	tctgGCTGCTGatctgcta	0	CAGCAGCA	m7a	Created	NA	NA	No effect
hsa-miR-4291	tctggCTGCTGAtctgcta	0	UUCAGCAG	m7b	Created	no TS	-0.158000	No effect
hsa-miR-497-5p	tctgGCTGCTGatctgcta	0	CAGCAGCA	m7a	Created	NA	NA	-3.180000
hsa-miR-761	tctggCTGCTGatctgcta	0	GCAGCAGG	m6b	Created	no TS	-0.113000	0.690000
hsa-miR-922	tctggCTGCTGatctgcta	0	GCAGCAGA	m6b	Created	no TS	-0.119000	-1.200000
hsa-miR-214-3p	tctggCTGCTGatctgcta	0	ACAGCAGG	m6b	Created	no TS	-0.120000	-6.600000
hsa-miR-424-5p	tctgGCTGCTGatctgcta	0	CAGCAGCA	m7a	Created	NA	NA	No effect
hsa-miR-4291	tctggCTGCTGAtctgcta	0	UUCAGCAG	m7b	Created	no TS	-0.158000	No effect
hsa-miR-497-5p	tctgGCTGCTGatctgcta	0	CAGCAGCA	m7a	Created	NA	NA	-3.180000
hsa-miR-761	tctggCTGCTGatctgcta	0	GCAGCAGG	m6b	Created	no TS	-0.113000	0.690000
hsa-miR-922	tctggCTGCTGatctgcta	0	GCAGCAGA	m6b	Created	no TS	-0.119000	-1.200000
hsa-miR-214-3p	tctggCTGCTGatctgcta	0	ACAGCAGG	m6b	Created	no TS	-0.12	-6.6
hsa-miR-424-5p	tctgGCTGCTGatctgcta	0	CAGCAGCA	m7a	Created	NA	NA	No effect
hsa-miR-4291	tctggCTGCTGAtctgcta	0	UUCAGCAG	m7b	Created	no TS	-0.158	No effect
hsa-miR-497-5p	tctgGCTGCTGatctgcta	0	CAGCAGCA	m7a	Created	NA	NA	-3.18
hsa-miR-761	tctggCTGCTGatctgcta	0	GCAGCAGG	m6b	Created	no TS	-0.113	0.69
hsa-miR-922	tctggCTGCTGatctgcta	0	GCAGCAGA	m6b	Created	no TS	-0.119	-1.2

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
95037104	rs1058932	C
			T	hsa-miR-1288-5p hsa-miR-214-3p hsa-miR-3617-3p hsa-miR-3619-5p hsa-miR-4291 hsa-miR-761 hsa-miR-922	2 2 2 2 2 2 2	ggctgcTGATCTG ggCTGCTGAtctg ggcTGCTGATctg ggCTGCTGAtctg ggCTGCTGAtctg ggCTGCTGAtctg ggCTGCTGAtctg	Created Created Created Created Created Created Created	N N N N N N N	-0.096 -0.12 -0.143 -0.12 -0.158 -0.113 -0.119

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