SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000104
Gene Symbol: CYP1B1
Description: Homo sapiens cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1), mRNA.
Gene Location: chr2(-):38294745-38303323
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr2:g.38067837A>C COSN9372749 AOCS-125-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5680 tagaCATTTCTaactcaag
 0 GAGAAAUG m7b Created no TS -0.226000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr2:g.38068104A>G COSN6682867 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr2:g.38068905G>C COSN1238451 HCC123T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4652-3p ggatggtAACAGAAaagag
 0 GUUCUGUU m7b Created no TS 0.040000 -2.400000
hsa-miR-4753-3p ggatggtAAGAGAAaagag
 3
 UUCUCUUU m7a Disrupted 0.162000 0.068000 0.660000
hsa-miR-4768-5p ggatggtaAGAGAAaagag
 0 AUUCUCUC m6b Disrupted 0.106000 0.031000 1.530000
hsa-miR-4652-3p ggatggtAACAGAAaagag
 0 GUUCUGUU m7b Created no TS 0.040000 -2.400000
hsa-miR-4753-3p ggatggtAAGAGAAaagag
 3
 UUCUCUUU m7a Disrupted 0.162000 0.068000 0.660000
hsa-miR-4768-5p ggatggtaAGAGAAaagag
 0 AUUCUCUC m6b Disrupted 0.106000 0.031000 1.530000
hsa-miR-4652-3p ggatggtAACAGAAaagag
 0 GUUCUGUU m7b Created no TS 0.04 -2.4
hsa-miR-4753-3p ggatggtAAGAGAAaagag
 0 UUCUCUUU m7a Disrupted 0.162 0.068 0.66
hsa-miR-4768-5p ggatggtaAGAGAAaagag
 0 AUUCUCUC m6b Disrupted 0.106 0.031 1.53

Mutation Mutation ID Sample Name Cancer Type
chr2:g.38069676A>G COSN4991944 SS6003302 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273g-5p aaatCAACCACCtattttt
 2
 GGUGGUUG m8a Disrupted -0.148000 no TS 3.400000
hsa-miR-323a-5p aaatcaACCACCTattttt
 0 AGGUGGUC m7a Disrupted NA NA 3.520000
hsa-miR-876-3p aaatcAACCACCtattttt
 0 UGGUGGUU m7b Disrupted -0.135000 no TS 1.260000
hsa-miR-1273g-5p aaatCAACCACCtattttt
 2
 GGUGGUUG m8a Disrupted -0.148000 no TS 3.400000
hsa-miR-323a-5p aaatcaACCACCTattttt
 0 AGGUGGUC m7a Disrupted NA NA 3.520000
hsa-miR-876-3p aaatcAACCACCtattttt
 0 UGGUGGUU m7b Disrupted -0.135000 no TS 1.260000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.38069761A>T COSN9999883 C0086T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-126-5p aggttgAATAATatatgcc
 0 CAUUAUUA m6b Disrupted 0.089000 -0.009000 No effect
hsa-miR-374b-5p aggttgaATTATATatgcc
 0 AUAUAAUA m7a Created -0.061000 -0.061000 -0.910000
hsa-miR-410 aggttgaaTTATATatgcc
 0 AAUAUAAC m6b Created 0.020000 0.124000 No effect
hsa-miR-4760-3p aggtTGAATTatatatgcc
 3
 AAAUUCAU m6b Created 0.276000 0.334000 No effect
hsa-miR-4795-3p aggttgAATAATATatgcc
 0 AUAUUAUU m8a Disrupted -0.063000 -0.133000 0.120000
hsa-miR-5011-5p aggttgaatTATATATgcc
 0 UAUAUAUA m7b (m6b->m7b) no TS 0.076000 No effect
hsa-miR-656 aggttgaATAATATatgcc
 2
 AAUAUUAU m7b Disrupted 0.206000 0.153000 -0.110000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.38070458T>C COSN9999884 C0086T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4480 gcatCTTGGCTatttctga
 0 AGCCAAGU m7a Created NA NA -6.580000
hsa-miR-4662a-5p gcatcTTGGCTAtttctga
 0 UUAGCCAA m7b Created no TS -0.183000 -0.620000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
38069113 rs4630747 A
T hsa-miR-4666a-3p
hsa-miR-4760-3p
hsa-miR-664a-3p
hsa-miR-7849-3p
3
3
3
4
 aatgaATTGTATg
aATGAATTgtatg
AATGAATtgtatg
aatgAATTGTAtg
 Created
Created
Created
Created
N
N
N
N
 0.111
0.114
0.134
0.1
38069549 rs3834137 - C hsa-miR-3686
hsa-miR-4742-3p
hsa-miR-4778-5p
5
3
5
 ataaTACAGAAtc
atAATACAGAatc
ataatACAGAATc
 Unknown
Unknown
Unknown
N
N
N
 -0.023
-0.054
-0.079
- hsa-miR-4795-3p
5
 ATAATAAgaatc
 Unknown
N
 0.103
38070256 rs9341260 G G hsa-miR-593-3p
hsa-miR-6818-3p
hsa-miR-6895-3p
1
1
1
 gaCAGAGACAagt
gacAGAGACAAgt
gacAGAGACAagt
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.304
-0.222
-0.101
A hsa-miR-4652-3p
hsa-miR-4743-3p
hsa-miR-6888-3p
1
1
1
 gACAGAAAcaagt
GACAGAAAcaagt
GACAGAAacaagt
 Created
Created
Created
N
N
N
 -0.037
-0.226
-0.126

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