SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000499
Gene Symbol:	CYP1A1
Description:	Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), mRNA.
Gene Location:	chr15(-):75011882-75017877
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.74719774G>-			ICGC_ssm_v2_93925		HX13T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4640-3p	gagggGGGGGTatttcaat	0	CACCCCCU	m6b	Disrupted	-0.220000	-0.230000	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.74720282C>A			COSN1180086		HCC63T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4724-3p	cagagacaaAAGGTAaaac	0	GUACCUUC	m6b	Created	no TS	-0.074000	-6.640000
hsa-miR-4724-3p	cagagacaaAAGGTAaaac	0	GUACCUUC	m6b	Created	no TS	-0.074	-6.64

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
74719773	rs200937928	-	-	hsa-miR-4640-3p hsa-miR-6798-3p	0	gGGGGGTAtttca gGGGGGTAtttca	Unknown Unknown	N N	-0.001 0.022
			G
74719775	rs28399432	G	G	hsa-miR-4640-3p hsa-miR-6798-3p	0	gggGGGGGTAttt gggGGGGGTAttt	Disrupted Disrupted	N N	-0.22 -0.246
74719776	rs17861085	T	G	hsa-miR-6798-3p	0	agggGGGGGTAtt	Created	N	-0.246
			T	hsa-miR-4640-3p	0	AGGGGGTggtatt	Disrupted	N	-0.01

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