SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000103
Gene Symbol:	CYP19A1
Description:	Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 (CYP19A1), transcript variant 1, mRNA.
Gene Location:	chr15(-):51500253-51630795
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51208422A>T			COSN1678698		RK165_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-181b-3p	taaattaTCAGTGAaatgc	6	CUCACUGA	m7b	Disrupted	-0.457000	-0.130000	0.770000
hsa-miR-27a-3p	taaattatCTGTGAAatgc	3	UUCACAGU	m7a	Created	-0.076000	-0.184000	-0.380000
hsa-miR-27b-3p	taaattatCTGTGAAatgc	3	UUCACAGU	m7a	Created	-0.076000	-0.184000	-0.150000
hsa-miR-4420	taaattaTCAGTGAaatgc	6	GUCACUGA	m7b	Disrupted	-0.503000	-0.176000	0.010000
hsa-miR-513a-5p	taaattatCTGTGAAatgc	3	UUCACAGG	m7a	Created	-0.085000	-0.192000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51208497G>A			COSN5398394		RK134_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4765	tgcttaaccATCACTCttg	0	UGAGUGAU	m7b	(m6b->m7b)	no TS	-0.144000	-0.140000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51208524T>C			COSN8174427		PCSI_0303_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-148a-5p	tcttcAGAACTTTgcccca	0	AAAGUUCU	m8a	Created	no TS	-0.046000	-0.760000
hsa-miR-148b-5p	tcttCAGAACTTtgcccca	0	AAGUUCUG	m8a	Created	no TS	-0.157000	-2.460000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51209104G>A			COSN7047718		8058330		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3924	cctgaATACATATgtagtc	0	AUAUGUAU	m8a	Created	no TS	0.041000	No effect
hsa-miR-5580-3p	cctgaataCATATGTagtc	0	CACAUAUG	m7b	Created	no TS	0.003000	0.140000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51209371G>C			COSN8746299		AOCS-152-1-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1976	tccctgaaaGCAGGAGcta	5	CCUCCUGC	m7b	(m7b->m6b)	-0.076000	no TS	3.450000
hsa-miR-29b-1-5p	tccctgAAACCAGgagcta	0	GCUGGUUU	m7b	Created	no TS	0.060000	No effect
hsa-miR-29b-2-5p	tccctGAAACCAGgagcta	5	CUGGUUUC	m8a	Created	-0.030000	0.019000	No effect
hsa-miR-3160-5p	tccctGAAAGCaggagcta	5	GGCUUUCU	m6b	Disrupted	0.069000	no TS	No effect
hsa-miR-370	tccctgaaAGCAGGagcta	5	GCCUGCUG	m6b	Disrupted	-0.022000	no TS	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.51210002G>A			COSN6275179		RK123_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-373-3p	tcacatgatGCACTTCaaa	0	GAAGUGCU	m7a	(m7a->m6a)	NA	NA	0.530000
hsa-miR-519a-3p	tcacatgaTGCACTTcaaa	2	AAAGUGCA	m7b	Disrupted	-0.127000	no TS	5.250000
hsa-miR-519b-3p	tcacatgaTGCACTTcaaa	2	AAAGUGCA	m7b	Disrupted	-0.127000	no TS	5.140000
hsa-miR-519c-3p	tcacatgaTGCACTTcaaa	2	AAAGUGCA	m7b	Disrupted	-0.127000	no TS	6.630000
hsa-miR-595	tcacatgatACACTTCaaa	0	GAAGUGUG	m7a	(m6a->m7a)	NA	NA	-0.090000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
51209885	rs1050787	T	T	hsa-miR-127-5p hsa-miR-181b-3p hsa-miR-3928-5p hsa-miR-4420 hsa-miR-6806-3p	2 3 2 3 2	acAGCTTCAgtga acagctTCAGTGA acAGCTTCAgtga acagctTCAGTGA acAGCTTCAgtga	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.027 -0.041 -0.037 -0.097 -0.034
			A	hsa-miR-1183 hsa-miR-1208 hsa-miR-3137 hsa-miR-6760-3p	2 3 2 3	acagCTACAGTga acagctACAGTGA acaGCTACAGtga acagctACAGTGA	Created Created Created Created	N N N N	-0.02 -0.001 -0.155 0.005

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