SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_003909
Gene Symbol: CPNE3
Description: Homo sapiens copine III (CPNE3), mRNA.
Gene Location: chr8(+):87526655-87573726
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr8:g.86559031C>G COSN9685005 AOCS-063-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-16-1-3p gcacATACTGagtttttta
 0 CCAGUAUU m6b Created no TS -0.040000 -0.090000
hsa-miR-4797-3p gcacaTACTGAGtttttta
 0 UCUCAGUA m7b Created no TS -0.162000 -0.100000
hsa-miR-548a-3p gcacatactCAGTTTTtta
 2
 CAAAACUG m7b (m7b->m6c) 0.026000 0.106000 0.130000
hsa-miR-548ar-3p gcacatactCAGTTTTtta
 2
 UAAAACUG m7b (m7b->m6c) 0.036000 0.116000 1.310000
hsa-miR-548e gcacatactCAGTTTTTta
 2
 AAAAACUG m8a (m8a->m7b) 0.054000 0.134000 1.390000
hsa-miR-548f gcacatactCAGTTTTTta
 2
 AAAAACUG m8a (m8a->m7b) 0.026000 0.106000 0.010000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.86559476G>T COSN15402015 AOCS-092-1-6 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-224-3p acgatACCATTTatctgtt
 1
 AAAAUGGU m7b Created -0.034000 -0.097000 -0.210000
hsa-miR-4694-3p acgataCCATTTatctgtt
 0 CAAAUGGA m6b Created no TS 0.035000 -0.010000
hsa-miR-4774-5p acgATACCAGttatctgtt
 2
 UCUGGUAU m7b (m7b->m6b) -0.264000 -0.188000 2.620000
hsa-miR-522-3p acgatACCATTTatctgtt
 1
 AAAAUGGU m7b Created -0.044000 -0.107000 -0.130000
hsa-miR-577 acgataccaTTTATCTgtt
 0 UAGAUAAA m7b (m6c->m7b) no TS -0.008000 -0.040000
hsa-miR-582-3p acgatACCAGTTAtctgtt
 2
 UAACUGGU m8a Disrupted -0.138000 no TS 0.300000
hsa-miR-224-3p acgatACCATTTatctgtt
 1
 AAAAUGGU m7b Created -0.034000 -0.097000 -0.210000
hsa-miR-4694-3p acgataCCATTTatctgtt
 0 CAAAUGGA m6b Created no TS 0.035000 -0.010000
hsa-miR-4774-5p acgATACCAGttatctgtt
 2
 UCUGGUAU m7b (m7b->m6b) -0.264000 -0.188000 2.620000
hsa-miR-522-3p acgatACCATTTatctgtt
 1
 AAAAUGGU m7b Created -0.044000 -0.107000 -0.130000
hsa-miR-577 acgataccaTTTATCTgtt
 0 UAGAUAAA m7b (m6c->m7b) no TS -0.008000 -0.040000
hsa-miR-582-3p acgatACCAGTTAtctgtt
 2
 UAACUGGU m8a Disrupted -0.138000 no TS 0.300000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.86559927A>G COSN8106997 8013222 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-125a-5p aatgcCTCAGGGgagtgag
 0 UCCCUGAG m7b Created no TS 0.033000 -0.310000
hsa-miR-125b-5p aatgcCTCAGGGgagtgag
 0 UCCCUGAG m7b Created no TS 0.051000 -0.080000
hsa-miR-1304-5p aatGCCTCAAgggagtgag
 2
 UUUGAGGC m7b (m7b->m6b) -0.006000 no TS 1.250000
hsa-miR-331-3p aatgcctCAGGGGagtgag
 0 GCCCCUGG m6b Created no TS 0.002000 -5.450000
hsa-miR-4287 aatgcctcAAGGGAGtgag
 2
 UCUCCCUU m7b Disrupted 0.040000 no TS 1.340000
hsa-miR-4319 aatgcCTCAGGGgagtgag
 0 UCCCUGAG m7b Created no TS 0.033000 -0.500000
hsa-miR-4649-3p aatGCCTCAGgggagtgag
 0 UCUGAGGC m7b (m6b->m7b) no TS 0.017000 -1.200000
hsa-miR-4685-3p aatgcctcAAGGGAGtgag
 2
 UCUCCCUU m7b Disrupted 0.077000 no TS -0.610000
hsa-miR-4780 aatgccTCAAGGGagtgag
 2
 ACCCUUGA m7b Disrupted 0.043000 no TS 1.340000
hsa-miR-544b aatgCCTCAGGggagtgag
 0 ACCUGAGG m7b Created no TS 0.013000 -1.250000
hsa-miR-623 aatgcctCAAGGGAgtgag
 2
 AUCCCUUG m7b Disrupted 0.028000 no TS 1.360000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.86559939C>T COSN2295100 RK016_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3670 gagTGAGCTCTcaaccaca
 5
 AGAGCUCA m8a Disrupted 0.030000 no TS No effect
hsa-miR-3670 gagTGAGCTCTcaaccaca
 5
 AGAGCUCA m8a Disrupted 0.03 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.86560147G>A COSN9685007 AOCS-161-1-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-592 tcaatagaTGACACAtcat
 5
 UUGUGUCA m7b Disrupted -0.300000 -0.241000 -0.560000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.86560272G>T COSN1369215 HX12T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3120-3p agatatgTTGCTGTGgttt
 6
 CACAGCAA m8a Disrupted 0.148000 0.132000 No effect
hsa-miR-494 agatATGTTTCtgtggttt
 0 UGAAACAU m7b Created no TS 0.046000 No effect
hsa-miR-3120-3p agatatgTTGCTGTGgttt
 4
 CACAGCAA m8a Disrupted 0.148 0.132 No effect
hsa-miR-494 agatATGTTTCtgtggttt
 0 UGAAACAU m7b Created no TS 0.046 No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.86560395T>G COSN8106998 8012352 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-296-5p gtggcaGGGGCCCagtcac
 0 AGGGCCCC m7b Created no TS -0.303000 No effect
hsa-miR-3649 gtggcagGGTCCCagtcac
 2
 AGGGACCU m6b Disrupted -0.429000 -0.345000 No effect
hsa-miR-4725-5p gtggCAGGGTCccagtcac
 5
 AGACCCUG m7b Disrupted -0.024000 no TS 7.110000
hsa-miR-504 gtggCAGGGTCccagtcac
 5
 AGACCCUG m7b Disrupted -0.043000 no TS No effect
hsa-miR-711 gtggcaGGGTCCCagtcac
 0 GGGACCCA m7a Disrupted NA NA -5.650000


Mutation Mutation ID Sample Name Cancer Type
chr8:g.86560599T>A 12_39 NA [upper_aerodigestive_tract][mouth][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr8:g.86560829A>T COSN15575703 C0007T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-5p ccaccATTCTTTtaagtgc
 0 CAAAGAAU m7b Created -0.099000 -0.132000 -0.070000
hsa-miR-3646 ccaccaTTCATTTaagtgc
 10
 AAAAUGAA m7b Disrupted -0.036000 -0.092000 0.410000
hsa-miR-4790-3p ccACCATTCAtttaagtgc
 7
 UGAAUGGU m8a (m8a->m7a) -0.149000 -0.075000 1.240000

Mutation Mutation ID Sample Name Cancer Type
chr8:g.86560940A>G COSN9685008 AOCS-150-8-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1247-3p acggtgCCCGGGatagatg
 0 CCCCGGGA m6b Created no TS -0.218000 -2.520000
hsa-miR-1285-3p acggTGCCCAGgatagatg
 1
 UCUGGGCA m7b Disrupted -0.385000 -0.261000 0.140000
hsa-miR-1343 acggtgCCCAGGAtagatg
 1
 CUCCUGGG m7b Disrupted -0.265000 -0.070000 1.210000
hsa-miR-3187-5p acggTGCCCAGGatagatg
 1
 CCUGGGCA m8a Disrupted -0.409000 -0.276000 1.220000
hsa-miR-4532 acggtgCCCGGGatagatg
 0 CCCCGGGG m6b Created no TS -0.220000 -7.250000
hsa-miR-5189 acggTGCCCAGgatagatg
 1
 UCUGGGCA m7b Disrupted -0.419000 -0.295000 0.030000
hsa-miR-612 acggTGCCCAGgatagatg
 1
 GCUGGGCA m7b Disrupted -0.394000 -0.261000 0.030000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
86558430 rs201137975 T T hsa-miR-186-5p
5
 ATTCTTTtgtgtt
 Disrupted
N
 No Change
86559470 rs142966393 A A hsa-miR-4774-5p
2
 ctcacgATACCAG
 Disrupted
N
 -0.076
G hsa-miR-1263
2
 ctcacGGTACCAg
 Created
N
 -0.136
86559929 rs138886215 G G hsa-miR-4287
hsa-miR-4685-3p
hsa-miR-4780
hsa-miR-483-3p
hsa-miR-623
hsa-miR-6780b-3p
2
2
2
2
2
2
 ctcAAGGGAGtga
ctcAAGGGAGtga
cTCAAGGGAgtga
ctcaagGGAGTGA
ctCAAGGGAgtga
ctCAAGGGAgtga
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 0.04
0.077
0.043
0.017
0.028
0.031
T hsa-miR-3614-5p
hsa-miR-3680-5p
hsa-miR-6500-3p
2
2
2
 ctCAAGTGAgtga
ctcaAGTGAGTga
ctCAAGTGAgtga
 Created
Created
Created
N
N
N
 0.099
0.015
0.095
86559930 rs141924533 G G hsa-miR-4287
hsa-miR-4685-3p
hsa-miR-4780
hsa-miR-483-3p
hsa-miR-623
hsa-miR-6780b-3p
2
2
2
2
2
2
 tcAAGGGAGtgag
tcAAGGGAGtgag
TCAAGGGAgtgag
tcaagGGAGTGAg
tCAAGGGAgtgag
tCAAGGGAgtgag
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 0.04
0.077
0.043
0.017
0.028
0.031
T hsa-miR-3200-3p
hsa-miR-4999-3p
hsa-miR-6813-3p
2
2
2
 tCAAGGTAgtgag
tcaaGGTAGTGAg
tCAAGGTAgtgag
 Created
Created
Created
N
N
N
 0.044
-0.05
0.07
86559931 rs144698270 A A hsa-miR-4287
hsa-miR-4685-3p
hsa-miR-4780
hsa-miR-483-3p
hsa-miR-623
hsa-miR-6780b-3p
2
2
2
2
2
2
 cAAGGGAGtgagc
cAAGGGAGtgagc
CAAGGGAgtgagc
caagGGAGTGAgc
CAAGGGAgtgagc
CAAGGGAgtgagc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 0.04
0.077
-0.035
0.017
0.028
0.031
C hsa-miR-1249
2
 cAAGGGCGtgagc
 Created
N
 -0.053
86561416 rs8041 C G hsa-miR-215-3p
hsa-miR-3664-5p
hsa-miR-4714-5p
hsa-miR-514a-5p
hsa-miR-6773-3p
0 gTGACAGAgtagt
gtgACAGAGTAgt
gtgaCAGAGTAgt
gtgaCAGAGTAgt
GTGACAGAgtagt
 Created
Created
Created
Created
Created
N
N
N
N
N
 -0.146
-0.341
-0.135
-0.131
-0.414
C hsa-miR-4318
hsa-miR-4693-5p
hsa-miR-592
hsa-miR-597-5p
hsa-miR-892a
0 gtgaCACAGTAgt
gtgaCACAGTAgt
gTGACACAgtagt
GTGACACAgtagt
gtgACACAGTAgt
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.133
-0.226
-0.208
-0.462
-0.331

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