SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001190457
Gene Symbol:	CORO2B
Description:	Homo sapiens coronin, actin binding protein, 2B (CORO2B), transcript variant 2, mRNA.
Gene Location:	chr15(+):68924326-69020144
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.68726100G>A			COSN7247203		8050103		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1908	aggacCCCCGCCtaccacc	2	CGGCGGGG	m7b	Disrupted	-0.256000	no TS	No effect
hsa-miR-4447	aggaCCCCCACCtaccacc	2	GGUGGGGG	m8a	Created	-0.136000	-0.330000	No effect
hsa-miR-4472	aggaCCCCCACCtaccacc	2	GGUGGGGG	m8a	Created	-0.136000	-0.321000	No effect
hsa-miR-4787-5p	aggACCCCCGCctaccacc	1	GCGGGGGU	m8a	Disrupted	-0.228000	no TS	No effect
hsa-miR-663a	aggacCCCCGCCTaccacc	2	AGGCGGGG	m8a	Disrupted	-0.265000	no TS	0.010000
hsa-miR-92a-2-5p	aggacCCCCACCtaccacc	3	GGGUGGGG	m7b	Created	-0.095000	-0.269000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.68726678A>C			COSN8815704		SS6003317		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3117-5p	gtagggatTAGTGTCcccc	3	AGACACUA	m7b	Disrupted	-0.142000	-0.105000	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.68727043T>A			COSN8590283		1255_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1343	tcgtcctCCAGGAagctga	1	CUCCUGGG	m6b	Created	-0.157000	-0.164000	No effect
hsa-miR-2115-5p	tcgtcctccTGGAAGCTga	1	AGCUUCCA	m8a	(m8a->m7b)	-0.290000	-0.294000	0.010000
hsa-miR-3690	tcgtccTCCAGGaagctga	0	ACCUGGAC	m6b	Created	no TS	-0.049000	-0.630000
hsa-miR-4254	tcgtcCTCCAGGaagctga	4	GCCUGGAG	m7b	Created	-0.093000	-0.255000	-1.710000
hsa-miR-4459	tcgtCCTCCTGGaagctga	5	CCAGGAGG	m8a	Disrupted	-0.482000	-0.402000	No effect
hsa-miR-4768-3p	tcgtcCTCCTGGaagctga	5	CCAGGAGA	m7a	Disrupted	-0.112000	-0.112000	No effect
hsa-miR-516a-3p	tcgtcctccAGGAAGCtga	1	UGCUUCCU	m7b	(m6c->m7b)	-0.218000	-0.255000	No effect
hsa-miR-516b-3p	tcgtcctccAGGAAGCtga	1	UGCUUCCU	m7b	(m6c->m7b)	-0.218000	-0.255000	No effect
hsa-miR-665	tcgtcCTCCTGGaagctga	6	ACCAGGAG	m7b	Disrupted	-0.197000	no TS	2.100000

Mutation			Mutation ID		Sample Name		Cancer Type
chr15:g.68727051G>C			COSN1683101		RK052_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-27b-5p	ctggAAGCTCaggctgaga	0	AGAGCUUA	m6b	Created	no TS	-0.007000	-0.010000
hsa-miR-4293	ctggaagcTCAGGCTGaga	0	CAGCCUGA	m8a	Created	no TS	-0.050000	-8.270000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
68726100	rs187940117	G	G	hsa-miR-1908-5p hsa-miR-4787-5p hsa-miR-663a hsa-miR-6787-5p	2 1 2 2	acCCCCGCCtacc ACCCCCGcctacc acCCCCGCCtacc acCCCCGCCtacc	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.256 -0.228 -0.265 -0.303
			A	hsa-miR-4447 hsa-miR-4472 hsa-miR-6751-5p hsa-miR-6752-5p hsa-miR-6802-5p hsa-miR-6803-5p hsa-miR-6815-5p hsa-miR-6835-5p hsa-miR-6842-5p hsa-miR-6865-5p hsa-miR-7110-5p hsa-miR-92a-2-5p	2 2 1 1 2 1 2 1 1 2 1 2	aCCCCCACctacc aCCCCCACctacc ACCCCCAcctacc ACCCCCAcctacc acccCCACCTAcc ACCCCCAcctacc acccCCACCTAcc ACCCCCAcctacc ACCCCCAcctacc acccCCACCTAcc ACCCCCAcctacc acCCCCACCtacc	Created Created Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N N N	-0.194 -0.185 -0.146 -0.155 -0.105 -0.192 -0.117 -0.179 -0.155 -0.117 -0.155 -0.174

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