SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000089
Gene Symbol: COL1A2
Description: Homo sapiens collagen, type I, alpha 2 (COL1A2), mRNA.
Gene Location: chr7(+):94023872-94060544
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr7:g.94430575T>G COSN8047869 8057559 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1206 cagtttCATGAACtccttc
0 UGUUCAUG m7b Created no TS -0.171000 -4.040000
hsa-miR-433 cagttTCATGAactccttc
0 AUCAUGAU m6b Created no TS -0.052000 -4.190000
hsa-miR-4424 cagtttcaTTAACTCcttc
3
AGAGUUAA m7b Disrupted -0.134000 no TS 1.110000
hsa-miR-4653-3p cagtttcatTAACTCCttc
3
UGGAGUUA m7b (m7b->m6c) -0.189000 no TS 2.190000
hsa-miR-569 cagtttCATTAACTccttc
2
AGUUAAUG m8a Disrupted -0.125000 no TS 4.430000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.94430589G>A 0_292 Prostate cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1275 cctTCCCCCACtcccccaa
5
GUGGGGGA m8a Created -0.39 -0.663 -1.05
hsa-miR-4447 ccttCCCCCACtcccccaa
5
GGUGGGGG m7b Created no TS -0.3 -1.31
hsa-miR-4472 ccttCCCCCACtcccccaa
5
GGUGGGGG m7b Created no TS -0.3 -1.32
hsa-miR-4481 ccttccCCCACTCCcccaa
5
GGAGUGGG m8a Created no TS -0.19 -1.34
hsa-miR-4665-5p cctTCCCCCActcccccaa
5
CUGGGGGA m7b (m6b->m7b) -0.411 -0.694 2.11
hsa-miR-4723-5p cctTCCCCCActcccccaa
5
UGGGGGAG m7a (m6a->m7a) -0.449 -0.691 2.05
hsa-miR-4745-5p ccttccCCCACTCccccaa
5
UGAGUGGG m7b Created no TS -0.18 -1.28
hsa-miR-4781-5p ccttcCCCCGCTcccccaa
5
UAGCGGGG m7b Disrupted -0.297 no TS 7.56
hsa-miR-5698 cctTCCCCCActcccccaa
5
UGGGGGAG m7a (m6a->m7a) -0.449 -0.691 -1.0

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
94430587 rs1060399 C C hsa-miR-4271
hsa-miR-4725-3p
hsa-miR-4781-5p
hsa-miR-625-5p
hsa-miR-6780b-5p
1
1
2
2
1
CTTCCCCcgctcc
CTTCCCCcgctcc
cttcCCCCGCTcc
cTTCCCCCgctcc
CTTCCCCcgctcc
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
-0.155
-0.155
-0.297
-0.161
-0.146
94430588 rs190115417 C C hsa-miR-4781-5p
hsa-miR-6090
hsa-miR-625-5p
2
2
2
ttcCCCCGCTccc
ttccccCGCTCCC
TTCCCCCgctccc
Disrupted
Disrupted
Disrupted
N
N
N
-0.297
-0.239
-0.158
T hsa-miR-1909-3p
hsa-miR-6081
hsa-miR-6510-5p
hsa-miR-6722-3p
hsa-miR-6783-5p
2
2
2
2
2
ttCCCCTGCtccc
ttcccCTGCTCCc
ttcCCCTGCTccc
ttCCCCTGCtccc
TTCCCCTgctccc
Created
Created
Created
Created
Created
N
N
N
N
N
-0.277
-0.17
-0.211
-0.277
-0.152
94430598 rs6955879 A A hsa-miR-1275
hsa-miR-4260
hsa-miR-450a-2-3p
hsa-miR-4665-5p
hsa-miR-5572
hsa-miR-6751-5p
hsa-miR-6803-5p
hsa-miR-7109-5p
2
3
3
2
3
2
2
2
CCCCCAAaaattt
cCCCCAAAaattt
cCCCCAAAaattt
CCCCCAAaaattt
cCCCCAAAaattt
CCCCCAAaaattt
CCCCCAAaaattt
CCCCCAAaaattt
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
-0.204
-0.163
-0.15
-0.207
-0.176
-0.198
-0.208
-0.2
G hsa-miR-3606-3p
hsa-miR-4314
hsa-miR-4667-5p
hsa-miR-4700-5p
hsa-miR-513a-3p
hsa-miR-513c-3p
hsa-miR-637
hsa-miR-7155-5p
hsa-miR-8089
20
1
3
3
14
14
2
3
3
cccccaGAAATTT
ccCCCAGAAattt
cCCCCAGAaattt
cCCCCAGAaattt
cccccaGAAATTT
cccccaGAAATTT
CCCCCAGAaattt
cCCCCAGAaattt
cCCCCAGAaattt
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
0.043
-0.156
-0.199
-0.182
0.024
0.024
-0.518
-0.192
-0.196

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