SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_000088 |
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Gene Symbol: | COL1A1 |
Description: | Homo sapiens collagen, type I, alpha 1 (COL1A1), mRNA. |
Gene Location: | chr17(-):48261456-48279000 |
Browse Associations | |
Browse Pathways |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr17:g.50184475G>T | COSN8603362 | J17_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3613-3p |
tttTTTTTTGTggatgggg |
0 | ACAAAAAA | m8a | Disrupted | 0.161000 | 0.158000 |
0.590000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr17:g.50184643C>T | COSN8838177 | AOCS-055-1-7 | [ovary][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-2115-5p |
gggTGGAAGCggctcccca |
11 |
AGCUUCCA | m7b | (m7b->m6c) | -0.154000 | -0.143000 |
0.010000 |
|
hsa-miR-505-5p |
gggtggaagTGGCTCCCca |
10 |
GGGAGCCA | m8a | (m7a->m8a) | -0.276000 | -0.393000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr17:g.50184767A>C | COSN5179345 | PD3945a | [breast][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-3173-5p |
ttgtgccGCAGGGCtgggc |
4 |
UGCCCUGC | m7b | Disrupted | -0.071000 | no TS |
0.720000 |
hsa-miR-3940-3p |
ttgtgccgCCGGGCTGggc |
0 | CAGCCCGG | m8a | Created | no TS | -0.131000 |
-6.480000 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
50184194 | rs12944834 | A | A |
hsa-miR-2115-5p hsa-miR-3977 hsa-miR-516a-3p hsa-miR-516b-3p hsa-miR-6885-3p hsa-miR-7162-5p |
11 11 11 11 3 11 |
GGAAGCAaaagac gGAAGCAAaagac GGAAGCAaaagac GGAAGCAaaagac ggAAGCAAAAgac GGAAGCAaaagac |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
-0.143 -0.108 -0.184 -0.184 -0.163 -0.183 |
G |
hsa-miR-4790-5p hsa-miR-6830-3p |
3 14 |
ggAAGCGAAagac ggaagcGAAAGAC |
Created Created |
N N |
-0.18 -0.138 |
|||
50184475 | rs200882287 | G | G |
hsa-miR-3613-3p |
3 |
TTTTTTGtggatg |
Disrupted |
N |
0.003 |
50184476 | rs58879635 | - | TT |
hsa-miR-3613-3p |
3 |
ttTTTTTTGtggatg |
Unknown |
N |
-0.001 |
- | |||||||||
50185481 | rs201085309 | G | G |
hsa-miR-505-5p hsa-miR-6827-5p |
10 11 |
aaccTGGCTCCct aacctGGCTCCCt |
Disrupted Disrupted |
N N |
-0.165 -0.267 |
C |
hsa-miR-1321 hsa-miR-1827 hsa-miR-3612 hsa-miR-4736 hsa-miR-4739 hsa-miR-4756-5p hsa-miR-650 hsa-miR-657 hsa-miR-6808-5p hsa-miR-6893-5p hsa-miR-940 |
11 9 10 7 11 11 10 7 7 7 7 |
aacctgCCTCCCT aacCTGCCTCcct aaccTGCCTCCct aACCTGCCtccct aacctgCCTCCCT aacctgCCTCCCT aaccTGCCTCCct AACCTGCctccct aaCCTGCCTccct aaCCTGCCTccct aaCCTGCCTccct |
Created Created Created Created Created Created Created Created Created Created Created |
N N N N N N N N N N N |
-0.128 -0.129 -0.155 -0.206 -0.138 -0.11 -0.136 -0.086 -0.205 -0.186 -0.13 |
|||
50185482 | rs199806909 | G | G |
hsa-miR-505-5p hsa-miR-6827-5p |
10 11 |
caaccTGGCTCCc caacctGGCTCCC |
Disrupted Disrupted |
N N |
-0.165 -0.267 |
A |
hsa-miR-4300 hsa-miR-4633-3p hsa-miR-5591-5p hsa-miR-6500-5p hsa-miR-6726-5p hsa-miR-920 |
11 10 11 10 11 11 |
caacctAGCTCCC caaccTAGCTCCc caacctAGCTCCC caaccTAGCTCCc caacctAGCTCCC caacctAGCTCCC |
Created Created Created Created Created Created |
N N N N N N |
-0.197 -0.135 -0.234 -0.117 -0.215 -0.197 |