SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000080
Gene Symbol:	CHRNE
Description:	Homo sapiens cholinergic receptor, nicotinic, epsilon (CHRNE), mRNA.
Gene Location:	chr17(-):4801063-4806369
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.4897832G>A			COSN8603337		3765_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3649	tggctggcgAGGTCCCccc	0	AGGGACCU	m7b	(m6b->m7b)	no TS	-0.132000	-0.040000
hsa-miR-4258	tggcTGGCGGGGtcccccc	0	CCCCGCCA	m8a	Disrupted	-0.225000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.4897868G>T			COSN6657741		CHC433T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4279	aaGAGGAGAGgggggtcgg	4	CUCUCCUC	m8a	(m8a->m7b)	-0.117000	-0.145000	-0.500000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.4897934G>A			COSN8603338		J10_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-623	aagCAAGGGAcgtggagag	0	AUCCCUUG	m7b	(m6c->m7b)	no TS	-0.128000	-1.630000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.4898592T>C			COSN6657742		CHC433T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1292	gtgtgccCGTTCCCtggcg	0	UGGGAACG	m7b	Disrupted	-0.119000	no TS	-1.220000
hsa-miR-4270	gtgtgcccgCTCCCTGgcg	7	UCAGGGAG	m7b	(m6b->m7b)	-0.060000	-0.141000	No effect
hsa-miR-4441	gtgtgcccgCTCCCTGgcg	7	ACAGGGAG	m7b	(m6b->m7b)	-0.041000	-0.075000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.4898663C>T			COSN7437382		8066443		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4659a-5p	ccgccacCATGGCAttatg	0	CUGCCAUG	m7b	Created	no TS	-0.174000	-1.480000
hsa-miR-4659b-5p	ccgccacCATGGCAttatg	0	UUGCCAUG	m7b	Created	no TS	-0.174000	-1.580000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.4898671C>T			COSN6657743		CHC433T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
4898592	rs12936083	C	T	hsa-miR-1292-5p hsa-miR-6750-5p hsa-miR-6822-5p	0	tgccCGTTCCCtg tgcccGTTCCCTg tgcccGTTCCCTg	Created Created Created	N N N	-0.119 -0.069 -0.06
			C	hsa-miR-4270 hsa-miR-4441 hsa-miR-6090 hsa-miR-6754-5p	0	tgcccgCTCCCTG tgcccgCTCCCTG tgccCGCTCCCtg tgcccgCTCCCTG	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.081 -0.034 -0.179 -0.062

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