SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000579
Gene Symbol: CCR5
Description: Homo sapiens chemokine (C-C motif) receptor 5 (gene/pseudogene) (CCR5), transcript variant A, mRNA.
Gene Location: chr3(+):46411632-46417697
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr3:g.46374007G>A COSN5806858 EOPC-04_tumor [prostate][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-224-5p gtgcacaTGACTTagtttt
 1
 CAAGUCAC m6b Created -0.024000 -0.084000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.46374056T>A COSN8489281 4537_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3121-3p gagaggTCTATTTtaaaag
 0 UAAAUAGA m7b Created no TS -0.016000 3.270000
hsa-miR-3684 gagAGGTCTAttttaaaag
 3
 UUAGACCU m7b (m6b->m7b) -0.291000 -0.518000 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.46374819A>G COSN7699264 8066452 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1249 atttAGGGCGaggagacca
 0 ACGCCCUU m6b Created no TS -0.182000 No effect
hsa-miR-18b-3p atTTAGGGCAaggagacca
 3
 UGCCCUAA m8a (m8a->m7a) -0.269000 -0.137000 -0.330000
hsa-miR-1915-5p atttagGGCAAGGagacca
 3
 ACCUUGCC m7b Disrupted -0.225000 no TS -0.020000
hsa-miR-3157-3p attTAGGGCAaggagacca
 3
 CUGCCCUA m7b (m7b->m6b) -0.247000 no TS 0.370000
hsa-miR-4279 atttagggcGAGGAGAcca
 0 CUCUCCUC m7b (m6c->m7b) -0.015000 0.014000 No effect
hsa-miR-502-5p atttaggGCAAGGAgacca
 3
 AUCCUUGC m7b Disrupted -0.025000 no TS -0.030000
hsa-miR-874 atttAGGGCAaggagacca
 3
 CUGCCCUG m6b Disrupted -0.064000 no TS 12.480000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.46375318T>G COSN8489282 360_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5196-3p ggtGAGGATGgattaccta
 1
 UCAUCCUC m7b (m6b->m7b) -0.168000 -0.281000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr3:g.46375329T>C COSN9721071 C0041T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr3:g.46375333C>T COSN6768987 RK200_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-203 cctagtagtCATTTCAtgg
 3
 GUGAAAUG m7b (m7b->m6c) -0.120000 -0.144000 0.010000
hsa-miR-606 cctAGTAGTTatttcatgg
 0 AAACUACU m7b (m6b->m7b) no TS -0.172000 -1.020000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.46375775G>T cosmic_v64_1751961 ccRCC
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5591-3p ttagtgttTGGGTATattc
 0 AUACCCAU m7a Disrupted NA NA No effect

Mutation Mutation ID Sample Name Cancer Type
chr3:g.46375849A>T cosmic_v64_1751958 ccRCC
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-132-3p atacttgaGACTGTTttga
 0 UAACAGUC m7b Disrupted -0.265 -0.096 0.39
hsa-miR-212-3p atacttgaGACTGTTttga
 0 UAACAGUC m7b Disrupted -0.275 -0.096 0.07
hsa-miR-513c-5p ataCTTGAGActgttttga
 3
 UUCUCAAG m7b (m7b->m6b) -0.163 no TS 1.04
hsa-miR-514b-5p ataCTTGAGActgttttga
 3
 UUCUCAAG m7b (m7b->m6b) -0.182 no TS 0.32

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
46374073 rs146080174 C C hsa-miR-132-3p
hsa-miR-212-3p
2
2
 aagttACTGTTAt
aagttACTGTTAt
 Disrupted
Disrupted
N
N
 -0.096
-0.096
G hsa-miR-141-3p
hsa-miR-200a-3p
hsa-miR-4637
2
2
7
 aagttAGTGTTAt
aagttAGTGTTAt
aAGTTAGTgttat
 Created
Created
Created
N
N
N
 -0.085
-0.082
-0.189
46374907 rs141257116 G
G hsa-miR-5196-3p
0 attcgtGAGGATG
 Disrupted
N
 -0.08
46374947 rs201290180 A A hsa-miR-20a-3p
hsa-miR-324-5p
hsa-miR-5196-3p
hsa-miR-6072
hsa-miR-6891-3p
2
2
1
2
2
 atgaggATGCAGA
atgaGGATGCAga
atGAGGATGcaga
ATGAGGAtgcaga
ATGAGGAtgcaga
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 0.013
-0.062
-0.073
-0.025
-0.001
T hsa-miR-2276-3p
hsa-miR-4772-3p
2
2
 atgaggTTGCAGA
atgagGTTGCAGA
 Created
Created
N
N
 0.017
-0.063
46375849 rs192256035 A A hsa-miR-132-3p
hsa-miR-212-3p
hsa-miR-513c-5p
hsa-miR-514b-5p
3
3
3
3
 cttgaGACTGTTt
cttgaGACTGTTt
CTTGAGActgttt
CTTGAGActgttt
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.169
-0.179
-0.163
-0.182

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