SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_004352
Gene Symbol:	CBLN1
Description:	Homo sapiens cerebellin 1 precursor (CBLN1), mRNA.
Gene Location:	chr16(-):49311828-49315742
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.49278083A>C			COSN14824061		8068597		[pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1908	gttttataCCCCGCCtctg	0	CGGCGGGG	m7b	Created	no TS	-0.360000	-0.370000
hsa-miR-568	gttTTATACAccgcctctg	2	AUGUAUAA	m7b	(m7b->m6c)	-0.055000	no TS	0.630000
hsa-miR-663a	gttttataCCCCGCCTctg	0	AGGCGGGG	m8a	Created	no TS	-0.351000	-3.580000

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.49278759G>A			COSN8819391		SS6003111		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-22-5p	tttgtatacGAAGAACTct	9	AGUUCUUC	m8a	(m8a->m7a)	-0.092000	no TS	1.450000
hsa-miR-568	tttgTATACAaagaactct	2	AUGUAUAA	m6b	Created	-0.055000	-0.084000	-0.180000

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.49279048A>G			COSN1699274		RK126_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-205-3p	ataatCTGAAATCtttctc	9	GAUUUCAG	m8a	Disrupted	-0.231000	-0.106000	0.220000
hsa-miR-3156-5p	ataatctgAGATCTTTctc	0	AAAGAUCU	m8a	Created	no TS	-0.077000	-4.980000
hsa-miR-3942-3p	ataATCTGAAAtctttctc	1	UUUCAGAU	m8a	Disrupted	-0.252000	-0.024000	2.050000
hsa-miR-4330	ataATCTGAGatctttctc	0	CCUCAGAU	m7b	(m6c->m7b)	no TS	-0.278000	-2.840000
hsa-miR-4695-3p	ataatcTGAGATCtttctc	0	UGAUCUCA	m7b	Created	no TS	-0.162000	-0.020000
hsa-miR-5100	ataATCTGAAatctttctc	1	UUCAGAUC	m7a	(m7a->m6b)	-0.091000	no TS	0.750000
hsa-miR-205-3p	ataatCTGAAATCtttctc	0	GAUUUCAG	m8a	Disrupted	-0.231	-0.106	0.22
hsa-miR-3156-5p	ataatctgAGATCTTTctc	0	AAAGAUCU	m8a	Created	no TS	-0.077	-4.98
hsa-miR-3942-3p	ataATCTGAAAtctttctc	0	UUUCAGAU	m8a	Disrupted	-0.252	-0.024	2.05
hsa-miR-4330	ataATCTGAGatctttctc	0	CCUCAGAU	m7b	(m6c->m7b)	no TS	-0.278	-2.84
hsa-miR-4695-3p	ataatcTGAGATCtttctc	0	UGAUCUCA	m7b	Created	no TS	-0.162	-0.02
hsa-miR-5100	ataATCTGAAatctttctc	0	UUCAGAUC	m7a	(m7a->m6b)	-0.091	no TS	0.75

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
49278757	rs994079	A	A	hsa-miR-22-5p hsa-miR-5584-3p	9 13	atacGAAGAACtc atacgAAGAACTc	Disrupted Disrupted	N N	-0.092 -0.008
			G	hsa-miR-1238-3p hsa-miR-4326	9 9	ataCGAGGAActc atacGAGGAACtc	Created Created	N N	-0.16 -0.127

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