SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001080124
Gene Symbol:	CASP8
Description:	Homo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant F, mRNA.
Gene Location:	chr2(+):202098165-202152434
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.201287189A>G			COSN1818852		RK126_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-633	taatattCTATTAacttta	2	CUAAUAGU	m6b	Disrupted	-0.023000	no TS	No effect
hsa-miR-633	taatattCTATTAacttta	2	CUAAUAGU	m6b	Disrupted	-0.023000	no TS	No effect
hsa-miR-633	taatattCTATTAacttta	2	CUAAUAGU	m6b	Disrupted	-0.023	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.201287406T>A			COSN6932565		8044983		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4282	caaaaaAAATTTTtttttt	0	UAAAAUUU	m7b	Disrupted	-0.033000	-0.037000	0.050000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
201287406	rs34552705	-	T	hsa-miR-4282	0	aaaAAATTTTttt	Unknown	N	-0.003
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