| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_032977 |
|---|---|
| Gene Symbol: | CASP10 |
| Description: | Homo sapiens caspase 10, apoptosis-related cysteine peptidase (CASP10), transcript variant 6, mRNA. |
| Gene Location: | chr2(+):202047620-202086383 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr2:g.201218606G>T | COSN9304062 | AOCS-143-1-0 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1263 |
tggcctgGGTACCAggtgc |
0 | AUGGUACC | m7b | Created | no TS | -0.068000 |
-0.160000 |
|
| hsa-miR-1295b-5p |
tggcCTGGGTaccaggtgc |
0 | CACCCAGA | m6b | Created | no TS | -0.050000 |
-0.010000 |
|
| hsa-miR-1915-3p |
tggCCTGGGGaccaggtgc |
0 | CCCCAGGG | m7a | (m7a->m6a) | NA | NA | No effect | |
| hsa-miR-2355-5p |
tggcCTGGGGAccaggtgc |
2 |
AUCCCCAG | m7b | Disrupted | -0.003000 | 0.010000 | No effect | |
| hsa-miR-4281 |
tggcctgGGGACCaggtgc |
3 |
GGGUCCCG | m6b | Disrupted | -0.295000 | -0.172000 | No effect | |
| hsa-miR-4482-5p |
tggcCTGGGTaccaggtgc |
2 |
AACCCAGU | m6b | Created | -0.044000 | -0.094000 | No effect | |
| hsa-miR-4726-3p |
tggCCTGGGTaccaggtgc |
1 |
ACCCAGGU | m7a | (m6a->m7a) | -0.079000 | -0.079000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr2:g.201219002A>G | ICGC_97B08466-2A78-11E2-8335-12FD496BB9B8 | CPCG_0102_Pr_P_P2 | ProstateCancer(OICR,CA) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr2:g.201219028G>A | COSN6932551 | 8016470 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-384 |
cagtactCTAGGAAgccaa |
0 | AUUCCUAG | m7b | Created | no TS | 0.064000 | No effect | |
| hsa-miR-516a-3p |
cagtactctAGGAAGCcaa |
0 | UGCUUCCU | m7b | (m6c->m7b) | no TS | -0.028000 |
-0.380000 |
|
| hsa-miR-516b-3p |
cagtactctAGGAAGCcaa |
0 | UGCUUCCU | m7b | (m6c->m7b) | no TS | -0.028000 |
-0.380000 |
|
| hsa-miR-5571-3p |
cagtactCTAGGAagccaa |
0 | GUCCUAGG | m6b | Created | no TS | 0.039000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr2:g.201219174A>G | ICGC_70B80C80-2A78-11E2-96E7-04FD496BB9B8 | CPCG_0102_Pr_P_P1 | ProstateCancer(OICR,CA) | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1976 |
gaggctgagGCAGGAGaat |
0 | CCUCCUGC | m7b | (m6c->m7b) | 0.039 | -0.018 |
-0.24 |
|
| hsa-miR-3120-5p |
gaggctgAGACAGGagaat |
0 | CCUGUCUG | m7a | Disrupted | -0.104 | -0.104 |
0.01 |
|
| hsa-miR-4421 |
gaggctgAGACAGGagaat |
1 |
ACCUGUCU | m7b | Disrupted | -0.043 | -0.087 | No effect | |
| hsa-miR-4722-3p |
gaggctgaGGCAGGagaat |
0 | ACCUGCCA | m6b | Created | -0.03 | -0.051 |
-0.01 |
|
| hsa-miR-5699 |
gaggctgAGACAGGAgaat |
1 |
UCCUGUCU | m8a | Disrupted | -0.016 | -0.05 |
0.11 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr2:g.201219927G>T | COSN5494587 | RK101_C01 | [liver][NS][carcinoma][NS] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-186-3p |
gaatgcCTTTGGGCgtgga |
0 | GCCCAAAG | m8a | Created | no TS | 0.106000 |
-1.210000 |
| hsa-miR-3910 |
gaATGCCTTTgggcgtgga |
2 |
AAAGGCAU | m8a | (m7a->m8a) | -0.148000 | -0.176000 | No effect |
| hsa-miR-548an |
gaaTGCCTTTgggcgtgga |
0 | AAAAGGCA | m7b | (m6b->m7b) | -0.156000 | -0.076000 |
-0.040000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 201217818 | rs191438878 | T | T |
hsa-miR-145-3p |
3 |
cAGGAATCggtgg |
Disrupted |
N |
-0.059 |
| G |
hsa-miR-516a-3p hsa-miR-516b-3p hsa-miR-7162-5p |
3 3 3 |
cAGGAAGCggtgg cAGGAAGCggtgg cAGGAAGCggtgg |
Created Created Created |
N N N |
-0.109 -0.109 -0.099 |
|||
| 201218910 | rs185024061 | G | G |
hsa-miR-155-3p hsa-miR-3685 |
2 2 |
ttcccTGTAGGAA ttccctGTAGGAA |
Disrupted Disrupted |
N N |
0.005 -0.039 |
| C |
hsa-miR-384 hsa-miR-520g-5p hsa-miR-5571-3p hsa-miR-6873-5p hsa-miR-7975 |
2 2 2 2 2 |
ttccctCTAGGAA ttcCCTCTAGgaa ttccctCTAGGAA tTCCCTCTAggaa ttccctCTAGGAA |
Created Created Created Created Created |
N N N N N |
0.014 -0.052 -0.004 -0.111 -0.006 |
|||
| 201219655 | rs185318287 | C | C |
hsa-miR-3186-5p |
1 |
taagGACGCCTtg |
Disrupted |
N |
-0.139 |
| T |
hsa-miR-3910 |
1 |
taaggATGCCTTg |
Created |
N |
0.076 |
|||
| 201219922 | rs41443046 | G | G |
hsa-miR-3910 |
1 |
tggaATGCCTTgg |
Disrupted |
N |
0.1 |
| T |
hsa-miR-6830-5p |
1 |
tggaaTTCCTTGg |
Created |
N |
0.114 |