SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000061
Gene Symbol: BTK
Description: Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), mRNA.
Gene Location: chrX(-):100604434-100641212
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Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chrX:g.101349769A>C ICGC_snv_9830 GC8_T [stomach][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-223-5p ctcAATACACaaaggcccc
0 CGUGUAUU m7b (m6c->m7b) no TS -0.182 0.71
hsa-miR-3149 ctcaATACAAAaaggcccc
0 UUUGUAUG m7a Disrupted 0.008 no TS 4.35
hsa-miR-5010-3p ctcaatACACAAAggcccc
0 UUUUGUGU m7b Created no TS -0.046 0.01
hsa-miR-599 ctcaatACACAAaggcccc
0 GUUGUGUC m6b Created no TS -0.03 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
101349769 rs700 A A hsa-miR-3149
1
aATACAAAaaggc
Disrupted
N
0.008
C hsa-miR-223-5p
hsa-miR-5010-3p
hsa-miR-599
1
1
1
AATACACAaaggc
aatACACAAAggc
aatACACAAAggc
Created
Created
Created
N
N
N
-0.182
-0.046
-0.03

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