SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_007297
Gene Symbol:	BRCA1
Description:	Homo sapiens breast cancer 1, early onset (BRCA1), transcript variant 1, mRNA.
Gene Location:	chr17(-):41196311-41277468
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.43044739G>A			COSN8836839		AOCS-057-1-2		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4773	aaagaatgTGTTCTaaaac	2	CAGAACAG	m6b	Disrupted	-0.085000	no TS	0.410000
hsa-miR-5687	aaagaatgtGTTCTAAaac	2	UUAGAACG	m7a	(m7a->m6a)	-0.093000	no TS	4.880000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.43044803G>C			COSN7435585		8030032		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3140-3p	aaaaAAAAGCaaaatgaaa	0	AGCUUUUG	m6b	Created	no TS	-0.049000	-0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
43045572	rs189442183	C	C	hsa-miR-4436a hsa-miR-4645-3p hsa-miR-5000-3p	2 1 2	tacTGTCCTGgct TACTGTCctggct tacTGTCCTGgct	Disrupted Disrupted Disrupted	N N N	-0.221 -0.137 -0.193
			T	hsa-miR-4773 hsa-miR-589-3p	2 2	taCTGTTCTggct tacTGTTCTGgct	Created Created	N N	-0.152 -0.116

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