SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_138625
Gene Symbol:	BCL2L11
Description:	Homo sapiens BCL2-like 11 (apoptosis facilitator) (BCL2L11), transcript variant 11, mRNA.
Gene Location:	chr2(+):111878490-111926022
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.111150115G>A			ICGC_1302762		TCGA-B5-A11Y-01A-21D-A10M-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-323b-3p	cggcGTATTGGagacgagt	0	CCCAAUAC	m7b	Disrupted	-0.232	no TS	0.21
hsa-miR-515-5p	cggcgtaTTGGAGAcgagt	0	UUCUCCAA	m7b	Disrupted	-0.23	-0.09	0.02
hsa-miR-519e-5p	cggcgtaTTGGAGAcgagt	0	UUCUCCAA	m7b	Disrupted	-0.23	-0.09	No effect
hsa-miR-5695	cggcgtaTTGGAGacgagt	0	ACUCCAAG	m6b	Disrupted	-0.072	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.111150120C>T			ICGC_1302763		TCGA-AP-A051-01A-21W-A027-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.111164160G>A			ICGC_1302764		TCGA-A5-A0GU-01A-11W-A062-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-647	caaGCAGCCAaagaccacc	0	GUGGCUGC	m7b	(m6b->m7b)	-0.165	-0.64	-2.23

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.111164172C>T			ICGC_1302765		TCGA-BS-A0UV-01A-11D-A10B-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3677-3p	gaccaCCCACGAatggtta	0	CUCGUGGG	m7b	Disrupted	-0.55	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.111164194->A			ICGC_1302766		TCGA-AJ-A23M-01A-11D-A159-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-132-3p	tacGACTGTTAcgttacat	0	UAACAGUC	m8a	Disrupted	-0.259000	-0.279000	0.240000
hsa-miR-194-5p	tacgaCTGTTACgttacat	0	UGUAACAG	m7b	Disrupted	-0.132000	no TS	0.360000
hsa-miR-212-3p	tacGACTGTTAcgttacat	0	UAACAGUC	m8a	Disrupted	-0.238000	-0.258000	0.220000

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.111166831A>T			ICGC_sm102534		RK023_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-183-3p	tagtggAATTCAattgtct	0	GUGAAUUA	m6b	Created	no TS	0.124	No effect
hsa-miR-4452	tagtgGAATTCAAttgtct	0	UUGAAUUC	m8a	Created	no TS	0.127	No effect
hsa-miR-630	tagtgGAATACaattgtct	0	AGUAUUCU	m6b	Disrupted	0.047	no TS	0.07

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
111150114	rs724710	C	T	hsa-miR-323b-3p hsa-miR-515-5p hsa-miR-519d-5p hsa-miR-519e-5p hsa-miR-5695	7 8 8 8 8	gcGTATTGGAgac gcgtaTTGGAGAc gcgtaTTGGAGAc gcgtaTTGGAGAc gcgtaTTGGAGAc	Created Created Created Created Created	N N N N N	-0.232 -0.14 -0.074 -0.14 -0.072

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