SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_007348
Gene Symbol:	ATF6
Description:	Homo sapiens activating transcription factor 6 (ATF6), mRNA.
Gene Location:	chr1(+):161736083-161928852
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161960193T>A			COSN5356126		RK152_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4712-3p	tggaTCTCATacagcgatg	0	AAUGAGAG	m6b	Disrupted	0.078000	no TS	0.040000
hsa-miR-4999-5p	tggatctcATACAGCgatg	0	UGCUGUAU	m7b	Disrupted	0.033000	no TS	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161960615A>G			COSN7180979		8012342		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-508-5p	ggagtCTGGAGTttgaaaa	0	UACUCCAG	m7b	Disrupted	-0.018000	no TS	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161961355C>T			COSN5732902		HX31T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3908	tgtCATTGCTtgttcttga	0	GAGCAAUG	m7b	(m6b->m7b)	no TS	-0.009000	-0.010000
hsa-miR-4742-5p	tgtcaTTGCCTGttcttga	0	UCAGGCAA	m7b	Disrupted	-0.015000	no TS	0.230000
hsa-miR-4773	tgtcattgcCTGTTCTtga	0	CAGAACAG	m7b	(m7b->m6c)	0.058000	-0.040000	0.570000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161961451T>C			COSN7180980		8031681		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-103a-2-5p	gcaAAGAAGCagtcacttt	4	AGCUUCUU	m7b	(m6b->m7b)	-0.185000	-0.129000	-0.030000
hsa-miR-134	gcaaagaagCAGTCACttt	0	UGUGACUG	m7b	(m6c->m7b)	-0.072000	-0.121000	-0.010000
hsa-miR-138-1-3p	gcaaaGAAGTAGtcacttt	0	GCUACUUC	m7b	Disrupted	-0.022000	no TS	No effect
hsa-miR-3118	gcaaagaagCAGTCACttt	0	UGUGACUG	m7b	(m6c->m7b)	-0.100000	-0.149000	-1.200000
hsa-miR-3682-5p	gcaaAGAAGTAGtcacttt	0	CUACUUCU	m8a	Disrupted	0.096000	0.088000	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161962474A>G			COSN1409525		RK035_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-548b-3p	tattttttGGTTCTTGcca	0	CAAGAACC	m8a	Created	0.102000	0.132000	-0.010000
hsa-miR-548b-3p	tattttttGGTTCTTGcca	0	CAAGAACC	m8a	Created	0.102	0.132	-0.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161963064G>A			COSN7180981		8014741		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-216a	cagggatTGAGATTgattt	0	UAAUCUCA	m7b	Created	-0.100000	-0.131000	No effect
hsa-miR-4733-5p	cagggaTTGGGATTgattt	0	AAUCCCAA	m8a	Disrupted	-0.067000	0.007000	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161963065G>T			COSN7180982		8014741		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4733-5p	agggaTTGGGATTgatttt	0	AAUCCCAA	m8a	Disrupted	-0.067000	0.007000	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161963286A>G			COSN6005442		RK210_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-323b-3p	tgtgtTATTGGatgcaata	0	CCCAAUAC	m6b	Created	no TS	-0.023000	-3.150000
hsa-miR-324-5p	tgtgttattGGATGCaata	0	CGCAUCCC	m6b	Created	no TS	-0.159000	-0.520000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.161963637T>C			COSN14563289		8067938		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-let-7a-3p	cagcaaTTGTATAttgatc	0	CUAUACAA	m7b	Disrupted	-0.105000	no TS	2.070000
hsa-let-7b-3p	cagcaaTTGTATAttgatc	0	CUAUACAA	m7b	Disrupted	-0.086000	no TS	0.160000
hsa-let-7f-1-3p	cagcaaTTGTATAttgatc	0	CUAUACAA	m7b	Disrupted	-0.086000	no TS	0.040000
hsa-miR-4666a-3p	cagcaATTGTATattgatc	0	CAUACAAU	m7b	Disrupted	-0.020000	0.061000	0.040000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
161958760	rs148286684	G
			A	hsa-miR-4524a-3p hsa-miR-4712-3p	1 1	TGTCTCAtactag tgTCTCATActag	Created Created	N N	-0.175 -0.092

Genome Browser