SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000046
Gene Symbol:	ARSB
Description:	Homo sapiens arylsulfatase B (ARSB), transcript variant 1, mRNA.
Gene Location:	chr5(-):78073036-78282357
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.78778542A>G			COSN9191897		AOCS-091-3-0		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3200-3p	tctataGCAAGGTtgtagc	3	CACCUUGC	m7b	Disrupted	-0.067000	no TS	0.230000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.78778695A>G			COSN2118355		RK015_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-617	gtaaatgaGGAAGTCTcac	0	AGACUUCC	m8a	Created	no TS	-0.068000	-0.230000
hsa-miR-617	gtaaatgaGGAAGTCTcac	0	AGACUUCC	m8a	Created	no TS	-0.068000	-0.230000
hsa-miR-617	gtaaatgaGGAAGTCTcac	0	AGACUUCC	m8a	Created	no TS	-0.068	-0.23

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.78779095G>T			COSN14747592		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-224-3p	cccACCATTTTgttcacca	0	AAAAUGGU	m8a	Created	no TS	0.109000	-0.050000
hsa-miR-4698	cccacCATTTTGttcacca	1	UCAAAAUG	m7b	Created	0.081000	0.244000	-0.120000
hsa-miR-522-3p	cccACCATTTTgttcacca	0	AAAAUGGU	m8a	Created	no TS	0.119000	-1.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.78780337G>A			COSN14794341		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
78779095	rs754566	T
			T	hsa-miR-224-3p hsa-miR-4698 hsa-miR-522-3p	0	ACCATTTtgttca acCATTTTGttca ACCATTTtgttca	Disrupted Disrupted Disrupted	N N N	0.109 0.163 0.119

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