SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_005100
Gene Symbol:	AKAP12
Description:	Homo sapiens A kinase (PRKA) anchor protein 12 (AKAP12), transcript variant 1, mRNA.
Gene Location:	chr6(+):151561133-151679694
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.151357245A>G			ICGC_A157035A-2A78-11E2-8335-12FD496BB9B8		CPCG_0102_Pr_P_P2		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1227	tggagtgcaGTGGCACGat	0	CGUGCCAC	m8a	(m7b->m8a)	no TS	-0.051	-1.881
hsa-miR-1273g-3p	tggagtGCAGTGGcacgat	0	ACCACUGC	m7b	Created	-0.072	-0.177	-5.63
hsa-miR-25-3p	tggaGTGCAATGgcacgat	0	CAUUGCAC	m8a	Disrupted	0.089	no TS	0.01
hsa-miR-32-5p	tggaGTGCAATggcacgat	0	UAUUGCAC	m7b	Disrupted	0.089	no TS	No effect
hsa-miR-363-3p	tggaGTGCAATggcacgat	0	AAUUGCAC	m7b	Disrupted	0.07	no TS	0.01
hsa-miR-367-3p	tggaGTGCAATggcacgat	0	AAUUGCAC	m7b	Disrupted	0.079	no TS	0.21
hsa-miR-4252	tggagtgCAGTGGCacgat	0	GGCCACUG	m7b	Created	no TS	-0.047	-2.03
hsa-miR-4793-3p	tggAGTGCAGtggcacgat	0	UCUGCACU	m7b	(m6b->m7b)	-0.119	-0.051	No effect
hsa-miR-92a-3p	tggaGTGCAATggcacgat	0	UAUUGCAC	m7b	Disrupted	0.089	no TS	0.04
hsa-miR-92b-3p	tggaGTGCAATggcacgat	0	UAUUGCAC	m7b	Disrupted	0.089	no TS	0.01

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.151357265C>T			ICGC_A1570832-2A78-11E2-8335-12FD496BB9B8		CPCG_0102_Pr_P_P2		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4746-3p	tcagctCACCGCaacctcc	0	AGCGGUGC	m6b	Disrupted	-0.08	no TS	9.31
hsa-miR-4792	tcaGCTCACCGcaacctcc	0	CGGUGAGC	m8a	Disrupted	-0.175	-0.141	1.25

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.151357288C>A			10_5013		6408		Breast cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
151357243	rs1134084	C	C	hsa-miR-25-3p hsa-miR-32-5p hsa-miR-363-3p hsa-miR-367-3p hsa-miR-4325 hsa-miR-7703 hsa-miR-92a-3p hsa-miR-92b-3p	1 1 1 1 1 1 1 1	ggaGTGCAATggc ggaGTGCAATggc ggaGTGCAATggc ggaGTGCAATggc ggAGTGCAAtggc gGAGTGCAAtggc ggaGTGCAATggc ggaGTGCAATggc	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N	0.089 0.089 0.07 0.079 0.033 -0.013 0.089 0.089
			G	hsa-miR-4436b-5p hsa-miR-6509-3p hsa-miR-6777-3p	1 1 1	ggAGTGGAAtggc ggAGTGGAAtggc gGAGTGGAatggc	Created Created Created	N N N	0.028 0.045 -0.012

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