SomamiR DB

SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only All 6mer or longer seed matches

PolymiRTS Database

RefSeq ID:	NM_182503
Gene Symbol:	ADAT2
Description:	Homo sapiens adenosine deaminase, tRNA-specific 2 (ADAT2), mRNA.
Gene Location:	chr6(-):143743968-143771841
Browse Associations

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.143422941G>T			COSN5084220		HX33T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3617	tgttttcTGTCTTagaatg	0	AAAGACAU	m6b	Created	-0.211000	-0.323000	0.010000
hsa-miR-641	tgttttcTGTCTTagaatg	0	AAAGACAU	m6b	Created	-0.211000	-0.326000	-0.760000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.143424271G>A			COSN5622881		RK057_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1343	cagacaCCAGGAattggtt	2	CUCCUGGG	m6b	Disrupted	0.025000	no TS	No effect
hsa-miR-4456	cagaCACCAGGaattggtt	0	CCUGGUGG	m7a	Disrupted	-0.078000	-0.078000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.143425207C>A			COSN6306656		RK181_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3662	agtctagaaCATTTTCact	7	GAAAAUGA	m7a	(m7a->m6a)	0.505000	0.505000	-0.010000
hsa-miR-4282	agtctagaAAATTTTcact	2	UAAAAUUU	m7b	Created	0.520000	0.763000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.143425779T>C			COSN1326104		HX10T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-147a	tatataaaaCACACACaca	2	GUGUGUGG	m7a	(m6a->m7a)	0.131000	0.131000	-0.080000
hsa-miR-223-5p	tatataaAATACACacaca	1	CGUGUAUU	m7b	Disrupted	0.100000	no TS	1.850000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.143426274C>T			COSN8398972		tumor_4163639		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3646	gaggTCATTTagcttcctg	2	AAAAUGAA	m6b	Created	0.444000	0.632000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.143426747G>T			COSN9311468		8051734		[pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-34a-3p	ttaCTGATTGaaatttggg	2	CAAUCAGC	m7a	(m7a->m6b)	-0.156000	-0.156000	No effect
hsa-miR-4705	ttacTGATTGAaatttggg	1	UCAAUCAC	m7a	Disrupted	-0.422000	-0.432000	No effect
hsa-miR-513a-3p	ttactgattGAAATTTggg	2	UAAAUUUC	m7b	(m7b->m6b)	0.763000	0.593000	0.010000
hsa-miR-513c-3p	ttactgattGAAATTTggg	2	UAAAUUUC	m7b	(m7b->m6b)	0.763000	0.593000	0.010000
hsa-miR-551b-5p	ttacTGATTTaaatttggg	0	GAAAUCAA	m6b	Created	no TS	0.110000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.143427307G>C			COSN191533		PD3904a		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1252	catTTCCTTCatgcaaagc	3	AGAAGGAA	m7b	(m6c->m7b)	0.011000	-0.076000	-4.910000
hsa-miR-4666b	catttccttCATGCAAagc	2	UUGCAUGU	m7a	(m6a->m7a)	-0.054000	-0.075000	-2.950000
hsa-miR-4711-5p	catttcctTGATGCAaagc	11	UGCAUCAG	m7a	Disrupted	-0.033000	no TS	0.990000
hsa-miR-5011-3p	catttccttCATGCAaagc	0	GUGCAUGG	m6b	Created	no TS	-0.026000	-0.010000
hsa-miR-561-5p	cattTCCTTGATgcaaagc	3	AUCAAGGA	m8a	Disrupted	-0.057000	0.010000	0.410000
hsa-miR-1252	catTTCCTTCatgcaaagc	0	AGAAGGAA	m7b	(m6c->m7b)	0.011	-0.076	-3.65
hsa-miR-4666b	catttccttCATGCAAagc	0	UUGCAUGU	m7a	(m6a->m7a)	-0.054	-0.075	-2.95
hsa-miR-4711-5p	catttcctTGATGCAaagc	0	UGCAUCAG	m7a	Disrupted	-0.033	no TS	0.99
hsa-miR-5011-3p	catttccttCATGCAaagc	0	GUGCAUGG	m6b	Created	no TS	-0.026	-0.01
hsa-miR-561-5p	cattTCCTTGATgcaaagc	0	AUCAAGGA	m8a	Disrupted	-0.057	0.01	0.41

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.143428158C>A			COSN14781574		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1254	cagTCCAGGCaagtgctga	2	AGCCUGGA	m7b	(m7b->m6c)	-0.348000	-0.002000	No effect
hsa-miR-1343	cagtCCAGGAaagtgctga	2	CUCCUGGG	m6b	Created	0.025000	-0.083000	-0.680000
hsa-miR-3074-5p	cagtcCAGGAAagtgctga	0	GUUCCUGC	m6b	Created	-0.423000	-0.479000	No effect
hsa-miR-3116	cagTCCAGGCAagtgctga	2	UGCCUGGA	m8a	Disrupted	-0.268000	0.026000	No effect
hsa-miR-3124-3p	cagtccAGGAAAGTgctga	6	ACUUUCCU	m8a	Created	0.087000	0.071000	No effect
hsa-miR-4254	cagTCCAGGCaagtgctga	3	GCCUGGAG	m7a	(m7a->m6b)	-0.268000	-0.389000	No effect
hsa-miR-661	cagtCCAGGCAagtgctga	1	UGCCUGGG	m7a	Disrupted	-0.136000	-0.009000	-0.580000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.143428238G>T			COSN14618955		8067175		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-302a-5p	ccatTTTAAGatgggggaa	3	ACUUAAAC	m6b	Disrupted	0.020000	-0.008000	-0.030000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.143428423T>C			COSN9969300		C0030T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-198	aaagtgacCTGGACaagat	6	GGUCCAGA	m6b	Disrupted	-0.173000	no TS	1.580000

**Germline mutations in target sites of miRNAs in somatic mutation table**
Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
143424163	rs71564436	G	G	hsa-miR-1238-3p hsa-miR-3124-3p hsa-miR-670-3p	8 6 8	agtGAGGAAAgga agtgAGGAAAGga agTGAGGAAAgga	Disrupted Disrupted Disrupted	N N N	0.045 0.087 0.061
143424163	rs71564436	G	A	hsa-miR-1229-3p hsa-miR-1304-3p hsa-miR-627-3p	10 7 6	aGTGAGAAaagga AGTGAGAaaagga agtgAGAAAAGga	Created Created Created	N N N	-0.001 0.04 0.147
143424872	rs149431960	T	T	hsa-miR-3662	2	aCATTTTAaacag	Disrupted	N	0.179
143424872	rs149431960	T	G	hsa-miR-105-5p hsa-miR-3671 hsa-miR-607 hsa-miR-7853-5p	2 2 2 2	aCATTTGAaacag acATTTGAAacag acATTTGAAAcag aCATTTGAaacag	Created Created Created Created	N N N N	0.092 0.14 0.298 0.099
143425733	rs62429066	-	A	hsa-miR-147a hsa-miR-5010-3p hsa-miR-599 hsa-miR-6818-5p hsa-miR-8068	0	CACACAAacacaa cACACAAAcacaa cACACAAAcacaa CACACAAacacaa cacACAAACAcaa	Unknown Unknown Unknown Unknown Unknown	N N N N N	-0.015 0.187 0.1 -0.015 0.116
143425733	rs62429066	-	C	hsa-miR-6867-5p	0	CACACACAcacaa	Unknown	N	0.362
143425734	rs71714792	-	CACACACACACACACA	hsa-miR-147a hsa-miR-5010-3p hsa-miR-599 hsa-miR-6818-5p hsa-miR-6867-5p hsa-miR-8068	0	cacacacacacacacaCACACAAacacaacacaccatggccct cacacacacacacacacACACAAAcacaacacaccatggccct cacacacacacacacacACACAAAcacaacacaccatggccct cacacacacacacacaCACACAAacacaacacaccatggccct cacacacacacacaCACACACAaacacaacacaccatggccct cacacacacacacacacacACAAACAcaacacaccatggccct	Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N	0.005 0.006 0.005 0.005 0.715 0.004
143425734	rs71714792	-	-	hsa-miR-6508-3p hsa-miR-6895-5p	0	cacacaaacacaacacaccATGGCCCt cacacaaacacaacacaccaTGGCCCT	Unknown Unknown	N N	No Change No Change
143425735	rs144783641	-	-	hsa-miR-147a hsa-miR-5010-3p hsa-miR-599 hsa-miR-6818-5p hsa-miR-6867-5p hsa-miR-8068	0	acaCACACAAacaca acacACACAAAcaca acacACACAAAcaca acaCACACAAacaca aCACACACAaacaca acacacACAAACAca	Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N	-0.011 0.187 0.1 -0.011 0.071 0.116
143425735	rs144783641	-	AC	hsa-miR-323b-5p hsa-miR-410-5p hsa-miR-494-5p hsa-miR-659-3p	0	acacACAACCAaacaca acacACAACCAaacaca acacACAACCAaacaca acacacAACCAAAcaca	Unknown Unknown Unknown Unknown	N N N N	-0.001 0.006 -0.001 0.101
143425737	rs71745624	-	-	hsa-miR-147a hsa-miR-5010-3p hsa-miR-599 hsa-miR-6818-5p hsa-miR-6867-5p	0	acacacacacaCACACAAacacaacac acacacacacacACACAAAcacaacac acacacacacacACACAAAcacaacac acacacacacaCACACAAacacaacac acacacaCACACACAcaaacacaacac	Unknown Unknown Unknown Unknown Unknown	N N N N N	-0.011 0.187 0.1 -0.011 0.013
143425737	rs71745624	-	ACACACAC
143425778	rs71024852	-	-	hsa-miR-223-5p hsa-miR-6867-5p	1 2	ataaAATACACAcac ataaaatACACACAc	Unknown Unknown	N N	No Change -0.091
143425778	rs71024852	-	AC
143427032	rs186535064	G	G	hsa-miR-18a-5p hsa-miR-18b-5p hsa-miR-4666b hsa-miR-4735-3p	7 7 2 8	ttacatGCACCTT ttacatGCACCTT ttACATGCAcctt ttacatGCACCTT	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.105 -0.105 -0.054 -0.142
143427032	rs186535064	G	A	hsa-miR-297 hsa-miR-379-3p hsa-miR-380-3p hsa-miR-411-3p hsa-miR-4495 hsa-miR-567	2 6 6 6 6 2	ttACATACAcctt TTACATAcacctt TTACATAcacctt TTACATAcacctt TTACATAcacctt ttACATACAcctt	Created Created Created Created Created Created	N N N N N N	-0.011 0.011 0.081 0.011 0.107 0.038
143428158	rs1065355	C	C	hsa-miR-1254 hsa-miR-3116 hsa-miR-6514-3p hsa-miR-661 hsa-miR-6894-3p	2 2 3 2 3	TCCAGGCAagtgc TCCAGGCAagtgc tcCAGGCAAgtgc tCCAGGCAagtgc tcCAGGCAAgtgc	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.346 -0.294 -0.123 -0.127 -0.115
143428158	rs1065355	C	A	hsa-miR-1343-3p hsa-miR-3074-5p hsa-miR-3124-3p hsa-miR-3690 hsa-miR-4254 hsa-miR-6783-3p hsa-miR-7152-5p	2 3 3 2 2 2 3	tCCAGGAAagtgc tcCAGGAAAgtgc tccAGGAAAGtgc TCCAGGAaagtgc TCCAGGAaagtgc tCCAGGAAagtgc tcCAGGAAAgtgc	Created Created Created Created Created Created Created	N N N N N N N	-0.108 -0.056 -0.016 -0.184 -0.121 -0.091 -0.05
143428237	rs186145080	A	A	hsa-miR-302a-5p	2	TTTAAGAtggggg	Disrupted	N	0.028
143428237	rs186145080	A	T	hsa-miR-6793-3p	2	tttaaGTTGGGGg	Created	N	-0.273
143428419	rs79235171	C	C	hsa-miR-198 hsa-miR-3655 hsa-miR-3912-5p	6 6 4	cCTGGACAagatt cctgGACAAGAtt ccTGGACAAgatt	Disrupted Disrupted Disrupted	N N N	-0.173 -0.157 -0.156
143428419	rs79235171	C	G	hsa-miR-3925-3p hsa-miR-515-5p hsa-miR-519e-5p hsa-miR-766-3p hsa-miR-942-5p	6 4 4 6 6	cCTGGAGAagatt ccTGGAGAAgatt ccTGGAGAAgatt cCTGGAGAagatt cctgGAGAAGAtt	Created Created Created Created Created	N N N N N	-0.157 -0.118 -0.118 -0.142 -0.103

**Genome Browser**
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Somatic mutations that impact miRNA target sites

Germline mutations in target sites of miRNAs in somatic mutation table

Genome Browser