SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001101667
Gene Symbol:	ACOX3
Description:	Homo sapiens acyl-CoA oxidase 3, pristanoyl (ACOX3), transcript variant 2, mRNA.
Gene Location:	chr4(-):8368008-8442452
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.8367029C>T			ICGC_1322487		TCGA-D1-A17Q-01A-11D-A12J-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3145-5p	gtgTTGGAGTgggcatcct	0	AACUCCAA	m7b	(m6c->m7b)	no TS	-0.068	-2.91
hsa-miR-4707-3p	gtgttggaGCGGGCatcct	0	AGCCCGCC	m6b	Disrupted	-0.253	no TS	1.67

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.8367059G>A			ICGC_1322488		TCGA-BG-A0MS-01A-11D-A10B-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2277-3p	ctctggggCGCTGTCctgc	0	UGACAGCG	m7b	Disrupted	-0.14	no TS	4.6
hsa-miR-371b-3p	ctctgGGGCACTgtcctgc	0	AAGUGCCC	m7b	Created	no TS	-0.245	-0.9

Mutation			Mutation ID		Sample Name		Cancer Type
chr4:g.8370916G>A			ICGC_1322489		TCGA-D1-A17H-01A-11D-A12J-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1306-3p	ggcagaGCCAACGgcgag	0	ACGUUGGC	m7b	Created	no TS	-0.274	No effect
hsa-miR-760	ggCAGAGCCGacggcgag	0	CGGCUCUG	m8a	(m8a->m7b)	-0.167	-0.376	0.3

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
8367029	rs149623650	C	C	hsa-miR-4707-3p	9	ttggaGCGGGCAt	Disrupted	N	-0.253
			T	hsa-miR-3145-5p	2	TTGGAGTgggcat	Created	N	-0.068
8370917	rs199611863	C	C	hsa-miR-6741-3p hsa-miR-760	6 6	cAGAGCCGAcggc CAGAGCCgacggc	Disrupted Disrupted	N N	-0.407 -0.167
			T	hsa-miR-6736-3p	6	caGAGCTGAcggc	Created	N	-0.096

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