SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000019
Gene Symbol:	ACAT1
Description:	Homo sapiens acetyl-CoA acetyltransferase 1 (ACAT1), nuclear gene encoding mitochondrial protein, mRNA.
Gene Location:	chr11(+):107992257-108018891
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.108147617T>G			COSN5893912		RK150_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4719	gatacATTTGTGcattctg	2	UCACAAAU	m7b	Created	-0.102000	-0.176000	-2.780000
hsa-miR-548aw	gatacatTTTTGCAttctg	1	GUGCAAAA	m7b	Disrupted	-0.169000	no TS	4.860000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.108147778A>C			COSN5893913		RK136_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4699-3p	tttacatttAGTAAATTac	1	AAUUUACU	m8a	(m8a->m7b)	-0.111000	no TS	-0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.108147798A>C			COSN5893914		RK136_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-32-3p	gtaaatTAAATTacttctc	2	CAAUUUAG	m6b	Disrupted	0.140000	0.103000	1.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr11:g.108148099A>G			COSN6531059		ICGC_MB8		[central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4317	caatacacGGCAATGcctg	0	ACAUUGCC	m7b	Created	no TS	-0.172000	-8.250000
hsa-miR-4440	caataCACGACAatgcctg	0	UGUCGUGG	m7a	Disrupted	-0.253000	no TS	0.160000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
108148097	rs181581446	C	C	hsa-miR-223-5p hsa-miR-4440	1 0	AATACACgacaat aataCACGACAat	Disrupted Disrupted	N N	-0.095 -0.253
			T	hsa-miR-6516-3p	0	aaTACATGAcaat	Created	N	-0.155

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