SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000033
Gene Symbol:	ABCD1
Description:	Homo sapiens ATP-binding cassette, sub-family D (ALD), member 1 (ABCD1), mRNA.
Gene Location:	chrX(+):152990322-153010216
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chrX:g.153744216G>T			ICGC_ED173076-2A78-11E2-89D1-29FD496BB9B8		CPCG_0103_Pr_P_P8		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1225-5p	gcccagtgGTACCCACagt	0	GUGGGUAC	m8a	Created	no TS	-0.099	-3.77
hsa-miR-1255b-2-3p	gcccAGTGGTacccacagt	0	AACCACUU	m6b	Created	no TS	-0.048	-5.58
hsa-miR-1273g-3p	gccCAGTGGTacccacagt	0	ACCACUGC	m7a	(m6a->m7a)	NA	NA	-1.44
hsa-miR-181a-2-3p	gccCAGTGGTacccacagt	0	ACCACUGA	m7a	(m6a->m7a)	NA	NA	-1.43
hsa-miR-3156-3p	gcccAGTGGGAcccacagt	2	CUCCCACU	m7b	Disrupted	-0.037	no TS	2.56
hsa-miR-4281	gcccagtGGGACCCacagt	0	GGGUCCCG	m7a	Disrupted	NA	NA	0.34
hsa-miR-4433-5p	gcccaGTGGGACccacagt	3	CGUCCCAC	m7b	Disrupted	-0.126	no TS	0.03

Mutation			Mutation ID		Sample Name		Cancer Type
chrX:g.153744422G>C			ICGC_ssm_v2_9987		HX4T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1207-5p	gtgactaCCCTGCCAgcag	0	UGGCAGGG	m8a	Created	-0.212	-0.539	-0.01
hsa-miR-4736	gtgactacCCTGCCagcag	0	AGGCAGGU	m6b	Created	-0.111	-0.221	-0.08
hsa-miR-4763-3p	gtgactaCCCTGCCagcag	0	AGGCAGGG	m7b	Created	-0.185	-0.522	No effect
hsa-miR-564	gtgactaCCGTGCCagcag	1	AGGCACGG	m7b	Disrupted	-0.453	no TS	4.4

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
153744216	rs199942817	G	G	hsa-miR-3156-3p hsa-miR-4301 hsa-miR-4433-5p	2 2 3	cAGTGGGAcccac cAGTGGGAcccac caGTGGGACccac	Disrupted Disrupted Disrupted	N N N	-0.037 -0.079 -0.126
			T	hsa-miR-1225-5p hsa-miR-1255b-2-3p	4 2	cagtgGTACCCAc cAGTGGTAcccac	Created Created	N N	-0.099 -0.048
153744638	rs78155328	G
			A	hsa-miR-3665 hsa-miR-4736 hsa-miR-5580-5p hsa-miR-764	2 2 2 2	gccagCACCTGCc gccagcACCTGCC GCCAGCAcctgcc gccaGCACCTGcc	Created Created Created Created	N N N N	-0.107 -0.128 -0.205 -0.112

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