| PolymiRTS Database 3.0 | ||||||||
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| Pathway ID | Pathway Class | Description | #PolymiRTS |
|---|---|---|---|
| Endocrine and metabolic diseases | Type II diabetes mellitus | 26 | |
| Endocrine and metabolic diseases | Type I diabetes mellitus | 9 | |
| Endocrine and metabolic diseases | Maturity onset diabetes of the young | 5 | |
| Neurodegenerative diseases | Alzheimer's disease | 93 | |
| Neurodegenerative diseases | Parkinson's disease | 68 | |
| Neurodegenerative diseases | Amyotrophic lateral sclerosis (ALS) | 25 | |
| Neurodegenerative diseases | Huntington's disease | 101 | |
| Neurodegenerative diseases | Prion diseases | 18 | |
| Infectious diseases: Bacterial | Bacterial invasion of epithelial cells | 49 | |
| Infectious diseases: Bacterial | Vibrio cholerae infection | 25 | |
| Infectious diseases: Bacterial | Epithelial cell signaling in Helicobacter pylori infection | 31 | |
| Infectious diseases: Bacterial | Pathogenic Escherichia coli infection | 37 | |
| Infectious diseases: Bacterial | Shigellosis | 50 | |
| Infectious diseases: Parasitic | Leishmaniasis | 31 | |
| Cancers: Overview | Pathways in cancer | 203 | |
| Cancers: Specific types | Colorectal cancer | 54 | |
| Cancers: Specific types | Renal cell carcinoma | 57 | |
| Cancers: Specific types | Pancreatic cancer | 60 | |
| Cancers: Specific types | Endometrial cancer | 42 | |
| Cancers: Specific types | Glioma | 47 | |
| Cancers: Specific types | Prostate cancer | 71 | |
| Cancers: Specific types | Thyroid cancer | 25 | |
| Cancers: Specific types | Basal cell carcinoma | 21 | |
| Cancers: Specific types | Melanoma | 45 | |
| Cancers: Specific types | Bladder cancer | 36 | |
| Cancers: Specific types | Chronic myeloid leukemia | 60 | |
| Cancers: Specific types | Acute myeloid leukemia | 45 | |
| Cancers: Specific types | Small cell lung cancer | 56 | |
| Cancers: Specific types | Non-small cell lung cancer | 45 | |
| Immune diseases | Asthma | 1 | |
| Immune diseases | Autoimmune thyroid disease | 5 | |
| Immune diseases | Systemic lupus erythematosus | 50 | |
| Immune diseases | Allograft rejection | 5 | |
| Immune diseases | Graft-versus-host disease | 7 | |
| Immune diseases | Primary immunodeficiency | 5 | |
| Cardiovascular diseases | Hypertrophic cardiomyopathy (HCM) | 40 | |
| Cardiovascular diseases | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 38 | |
| Cardiovascular diseases | Viral myocarditis | 29 |
| Pathway ID | Pathway Class | Description | #PolymiRTS |
|---|---|---|---|
| Cell growth and death | Cell cycle | 98 | |
| Cell growth and death | Oocyte meiosis | 66 | |
| Cell growth and death | p53 signaling pathway | 44 | |
| Transport and catabolism | Regulation of autophagy | 11 | |
| Transport and catabolism | Lysosome | 66 | |
| Transport and catabolism | Endocytosis | 103 | |
| Transport and catabolism | Peroxisome | 38 | |
| Cell growth and death | Apoptosis | 43 | |
| Cell communication | Focal adhesion | 121 | |
| Cell communication | Adherens junction | 55 | |
| Cell communication | Tight junction | 66 | |
| Cell communication | Gap junction | 39 | |
| Cell motility | Regulation of actin cytoskeleton | 122 |
| Pathway ID | Pathway Class | Description | #PolymiRTS |
|---|---|---|---|
| Membrane transport | ABC transporters | 12 | |
| Signal transduction | MAPK signaling pathway | 135 | |
| Signal transduction | ErbB signaling pathway | 61 | |
| Signal transduction | Calcium signaling pathway | 56 | |
| Signaling molecules and interaction | Cytokine-cytokine receptor interaction | 59 | |
| Signal transduction | Phosphatidylinositol signaling system | 40 | |
| Signaling molecules and interaction | Neuroactive ligand-receptor interaction | 33 | |
| Signal transduction | mTOR signaling pathway | 41 | |
| Signal transduction | Wnt signaling pathway | 78 | |
| Signal transduction | Notch signaling pathway | 24 | |
| Signal transduction | Hedgehog signaling pathway | 20 | |
| Signal transduction | TGF-beta signaling pathway | 46 | |
| Signal transduction | VEGF signaling pathway | 41 | |
| Signaling molecules and interaction | ECM-receptor interaction | 39 | |
| Signaling molecules and interaction | Cell adhesion molecules (CAMs) | 38 | |
| Signal transduction | Jak-STAT signaling pathway | 54 |
| Pathway ID | Pathway Class | Description | #PolymiRTS |
|---|---|---|---|
| Translation | Aminoacyl-tRNA biosynthesis | 31 | |
| Translation | Ribosome | 78 | |
| Folding, sorting and degradation | RNA degradation | 29 | |
| Transcription | RNA polymerase | 17 | |
| Transcription | Basal transcription factors | 16 | |
| Replication and repair | DNA replication | 22 | |
| Transcription | Spliceosome | 90 | |
| Folding, sorting and degradation | Proteasome | 34 | |
| Folding, sorting and degradation | Protein export | 16 | |
| Replication and repair | Base excision repair | 21 | |
| Replication and repair | Nucleotide excision repair | 27 | |
| Replication and repair | Mismatch repair | 19 | |
| Replication and repair | Homologous recombination | 17 | |
| Replication and repair | Non-homologous end-joining | 3 | |
| Folding, sorting and degradation | Ubiquitin mediated proteolysis | 77 | |
| Folding, sorting and degradation | SNARE interactions in vesicular transport | 15 |
| Pathway ID | Pathway Class | Description | #PolymiRTS |
|---|---|---|---|
| Carbohydrate metabolism | Glycolysis / Gluconeogenesis | 33 | |
| Carbohydrate metabolism | Citrate cycle (TCA cycle) | 20 | |
| Carbohydrate metabolism | Pentose phosphate pathway | 16 | |
| Carbohydrate metabolism | Pentose and glucuronate interconversions | 3 | |
| Carbohydrate metabolism | Fructose and mannose metabolism | 19 | |
| Carbohydrate metabolism | Galactose metabolism | 13 | |
| Carbohydrate metabolism | Ascorbate and aldarate metabolism | 5 | |
| Lipid metabolism | Fatty acid biosynthesis | 4 | |
| Lipid metabolism | Fatty acid metabolism | 24 | |
| Lipid metabolism | Synthesis and degradation of ketone bodies | 5 | |
| Lipid metabolism | Steroid biosynthesis | 11 | |
| Lipid metabolism | Primary bile acid biosynthesis | 5 | |
| Metabolism of cofactors and vitamins | Ubiquinone and other terpenoid-quinone biosynthesis | 2 | |
| Lipid metabolism | Steroid hormone biosynthesis | 5 | |
| Energy metabolism | Oxidative phosphorylation | 61 | |
| Nucleotide metabolism | Purine metabolism | 69 | |
| Biosynthesis of other secondary metabolites | Caffeine metabolism | 2 | |
| Nucleotide metabolism | Pyrimidine metabolism | 51 | |
| Amino acid metabolism | Alanine, aspartate and glutamate metabolism | 19 | |
| Amino acid metabolism | Glycine, serine and threonine metabolism | 13 | |
| Amino acid metabolism | Cysteine and methionine metabolism | 18 | |
| Amino acid metabolism | Valine, leucine and isoleucine degradation | 28 | |
| Amino acid metabolism | Valine, leucine and isoleucine biosynthesis | 7 | |
| Amino acid metabolism | Lysine biosynthesis | 1 | |
| Amino acid metabolism | Lysine degradation | 31 | |
| Amino acid metabolism | Arginine and proline metabolism | 27 | |
| Amino acid metabolism | Histidine metabolism | 8 | |
| Amino acid metabolism | Tyrosine metabolism | 9 | |
| Amino acid metabolism | Phenylalanine metabolism | 5 | |
| Amino acid metabolism | Tryptophan metabolism | 13 | |
| Amino acid metabolism | Phenylalanine, tyrosine and tryptophan biosynthesis | 2 | |
| Metabolism of other amino acids | beta-Alanine metabolism | 10 | |
| Metabolism of other amino acids | Taurine and hypotaurine metabolism | 2 | |
| Metabolism of other amino acids | Cyanoamino acid metabolism | 3 | |
| Metabolism of other amino acids | D-Glutamine and D-glutamate metabolism | 2 | |
| Metabolism of other amino acids | Glutathione metabolism | 20 | |
| Carbohydrate metabolism | Starch and sucrose metabolism | 11 | |
| Glycan biosynthesis and metabolism | N-Glycan biosynthesis | 24 | |
| Glycan biosynthesis and metabolism | Other glycan degradation | 4 | |
| Carbohydrate metabolism | Amino sugar and nucleotide sugar metabolism | 22 | |
| Biosynthesis of other secondary metabolites | Butirosin and neomycin biosynthesis | 1 | |
| Glycan biosynthesis and metabolism | Glycosaminoglycan degradation | 9 | |
| Lipid metabolism | Glycerolipid metabolism | 22 | |
| Carbohydrate metabolism | Inositol phosphate metabolism | 25 | |
| Glycan biosynthesis and metabolism | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis | 10 | |
| Lipid metabolism | Glycerophospholipid metabolism | 29 | |
| Lipid metabolism | Ether lipid metabolism | 7 | |
| Lipid metabolism | Arachidonic acid metabolism | 13 | |
| Lipid metabolism | Linoleic acid metabolism | 3 | |
| Lipid metabolism | alpha-Linolenic acid metabolism | 4 | |
| Lipid metabolism | Sphingolipid metabolism | 14 | |
| Glycan biosynthesis and metabolism | Glycosphingolipid biosynthesis - lacto and neolacto series | 5 | |
| Glycan biosynthesis and metabolism | Glycosphingolipid biosynthesis - globo series | 7 | |
| Glycan biosynthesis and metabolism | Glycosphingolipid biosynthesis - ganglio series | 5 | |
| Carbohydrate metabolism | Pyruvate metabolism | 23 | |
| Carbohydrate metabolism | Glyoxylate and dicarboxylate metabolism | 7 | |
| Carbohydrate metabolism | Propanoate metabolism | 19 | |
| Carbohydrate metabolism | Butanoate metabolism | 18 | |
| Metabolism of cofactors and vitamins | One carbon pool by folate | 11 | |
| Energy metabolism | Methane metabolism | 5 | |
| Metabolism of cofactors and vitamins | Thiamine metabolism | 4 | |
| Metabolism of cofactors and vitamins | Riboflavin metabolism | 6 | |
| Metabolism of cofactors and vitamins | Vitamin B6 metabolism | 3 | |
| Metabolism of cofactors and vitamins | Nicotinate and nicotinamide metabolism | 10 | |
| Metabolism of cofactors and vitamins | Pantothenate and CoA biosynthesis | 7 | |
| Metabolism of cofactors and vitamins | Folate biosynthesis | 4 | |
| Metabolism of cofactors and vitamins | Retinol metabolism | 8 | |
| Metabolism of cofactors and vitamins | Porphyrin and chlorophyll metabolism | 14 | |
| Metabolism of terpenoids and polyketides | Terpenoid backbone biosynthesis | 7 | |
| Metabolism of terpenoids and polyketides | Limonene and pinene degradation | 6 | |
| Energy metabolism | Nitrogen metabolism | 8 | |
| Energy metabolism | Sulfur metabolism | 3 | |
| Xenobiotics biodegradation and metabolism | Metabolism of xenobiotics by cytochrome P450 | 11 | |
| Xenobiotics biodegradation and metabolism | Drug metabolism - cytochrome P450 | 10 | |
| Xenobiotics biodegradation and metabolism | Drug metabolism - other enzymes | 14 | |
| Lipid metabolism | Biosynthesis of unsaturated fatty acids | 14 | |
| Global and overview maps | Metabolic pathways | 460 |
| Pathway ID | Pathway Class | Description | #PolymiRTS |
|---|---|---|---|
| Endocrine system | PPAR signaling pathway | 24 | |
| Immune system | Chemokine signaling pathway | 81 | |
| Circulatory system | Cardiac muscle contraction | 32 | |
| Circulatory system | Vascular smooth muscle contraction | 48 | |
| Development | Dorso-ventral axis formation | 18 | |
| Development | Axon guidance | 62 | |
| Immune system | Complement and coagulation cascades | 8 | |
| Immune system | Antigen processing and presentation | 21 | |
| Endocrine system | Renin-angiotensin system | 7 | |
| Immune system | Toll-like receptor signaling pathway | 41 | |
| Immune system | NOD-like receptor signaling pathway | 32 | |
| Immune system | RIG-I-like receptor signaling pathway | 23 | |
| Immune system | Cytosolic DNA-sensing pathway | 16 | |
| Immune system | Hematopoietic cell lineage | 20 | |
| Immune system | Natural killer cell mediated cytotoxicity | 48 | |
| Immune system | T cell receptor signaling pathway | 60 | |
| Immune system | B cell receptor signaling pathway | 45 | |
| Immune system | Fc epsilon RI signaling pathway | 41 | |
| Immune system | Fc gamma R-mediated phagocytosis | 50 | |
| Immune system | Leukocyte transendothelial migration | 54 | |
| Immune system | Intestinal immune network for IgA production | 9 | |
| Nervous system | Long-term potentiation | 43 | |
| Nervous system | Neurotrophin signaling pathway | 98 | |
| Nervous system | Long-term depression | 31 | |
| Sensory system | Olfactory transduction | 14 | |
| Sensory system | Taste transduction | 7 | |
| Sensory system | Phototransduction | 6 | |
| Endocrine system | Insulin signaling pathway | 87 | |
| Endocrine system | GnRH signaling pathway | 48 | |
| Endocrine system | Progesterone-mediated oocyte maturation | 56 | |
| Endocrine system | Melanogenesis | 40 | |
| Endocrine system | Adipocytokine signaling pathway | 37 | |
| Excretory system | Aldosterone-regulated sodium reabsorption | 22 | |
| Excretory system | Vasopressin-regulated water reabsorption | 26 | |
| Excretory system | Proximal tubule bicarbonate reclamation | 8 | |
| Excretory system | Collecting duct acid secretion | 9 |