PolymiRTS Database 3.0
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KEGG Pathways

Human     Mouse
PolymiRTS record type :

Human Diseases

Pathway ID Pathway Class Description #PolymiRTS
Endocrine and metabolic diseases Type II diabetes mellitus 26
Endocrine and metabolic diseases Type I diabetes mellitus 9
Endocrine and metabolic diseases Maturity onset diabetes of the young 5
Neurodegenerative diseases Alzheimer's disease 93
Neurodegenerative diseases Parkinson's disease 68
Neurodegenerative diseases Amyotrophic lateral sclerosis (ALS) 25
Neurodegenerative diseases Huntington's disease 101
Neurodegenerative diseases Prion diseases 18
Infectious diseases: Bacterial Bacterial invasion of epithelial cells 49
Infectious diseases: Bacterial Vibrio cholerae infection 25
Infectious diseases: Bacterial Epithelial cell signaling in Helicobacter pylori infection 31
Infectious diseases: Bacterial Pathogenic Escherichia coli infection 37
Infectious diseases: Bacterial Shigellosis 50
Infectious diseases: Parasitic Leishmaniasis 31
Cancers: Overview Pathways in cancer 203
Cancers: Specific types Colorectal cancer 54
Cancers: Specific types Renal cell carcinoma 57
Cancers: Specific types Pancreatic cancer 60
Cancers: Specific types Endometrial cancer 42
Cancers: Specific types Glioma 47
Cancers: Specific types Prostate cancer 71
Cancers: Specific types Thyroid cancer 25
Cancers: Specific types Basal cell carcinoma 21
Cancers: Specific types Melanoma 45
Cancers: Specific types Bladder cancer 36
Cancers: Specific types Chronic myeloid leukemia 60
Cancers: Specific types Acute myeloid leukemia 45
Cancers: Specific types Small cell lung cancer 56
Cancers: Specific types Non-small cell lung cancer 45
Immune diseases Asthma 1
Immune diseases Autoimmune thyroid disease 5
Immune diseases Systemic lupus erythematosus 50
Immune diseases Allograft rejection 5
Immune diseases Graft-versus-host disease 7
Immune diseases Primary immunodeficiency 5
Cardiovascular diseases Hypertrophic cardiomyopathy (HCM) 40
Cardiovascular diseases Arrhythmogenic right ventricular cardiomyopathy (ARVC) 38
Cardiovascular diseases Viral myocarditis 29


Cellular Processes

Pathway ID Pathway Class Description #PolymiRTS
Cell growth and death Cell cycle 98
Cell growth and death Oocyte meiosis 66
Cell growth and death p53 signaling pathway 44
Transport and catabolism Regulation of autophagy 11
Transport and catabolism Lysosome 66
Transport and catabolism Endocytosis 103
Transport and catabolism Peroxisome 38
Cell growth and death Apoptosis 43
Cell communication Focal adhesion 121
Cell communication Adherens junction 55
Cell communication Tight junction 66
Cell communication Gap junction 39
Cell motility Regulation of actin cytoskeleton 122


Environmental Information Processing

Pathway ID Pathway Class Description #PolymiRTS
Membrane transport ABC transporters 12
Signal transduction MAPK signaling pathway 135
Signal transduction ErbB signaling pathway 61
Signal transduction Calcium signaling pathway 56
Signaling molecules and interaction Cytokine-cytokine receptor interaction 59
Signal transduction Phosphatidylinositol signaling system 40
Signaling molecules and interaction Neuroactive ligand-receptor interaction 33
Signal transduction mTOR signaling pathway 41
Signal transduction Wnt signaling pathway 78
Signal transduction Notch signaling pathway 24
Signal transduction Hedgehog signaling pathway 20
Signal transduction TGF-beta signaling pathway 46
Signal transduction VEGF signaling pathway 41
Signaling molecules and interaction ECM-receptor interaction 39
Signaling molecules and interaction Cell adhesion molecules (CAMs) 38
Signal transduction Jak-STAT signaling pathway 54


Genetic Information Processing

Pathway ID Pathway Class Description #PolymiRTS
Translation Aminoacyl-tRNA biosynthesis 31
Translation Ribosome 78
Folding, sorting and degradation RNA degradation 29
Transcription RNA polymerase 17
Transcription Basal transcription factors 16
Replication and repair DNA replication 22
Transcription Spliceosome 90
Folding, sorting and degradation Proteasome 34
Folding, sorting and degradation Protein export 16
Replication and repair Base excision repair 21
Replication and repair Nucleotide excision repair 27
Replication and repair Mismatch repair 19
Replication and repair Homologous recombination 17
Replication and repair Non-homologous end-joining 3
Folding, sorting and degradation Ubiquitin mediated proteolysis 77
Folding, sorting and degradation SNARE interactions in vesicular transport 15


Metabolism

Pathway ID Pathway Class Description #PolymiRTS
Carbohydrate metabolism Glycolysis / Gluconeogenesis 33
Carbohydrate metabolism Citrate cycle (TCA cycle) 20
Carbohydrate metabolism Pentose phosphate pathway 16
Carbohydrate metabolism Pentose and glucuronate interconversions 3
Carbohydrate metabolism Fructose and mannose metabolism 19
Carbohydrate metabolism Galactose metabolism 13
Carbohydrate metabolism Ascorbate and aldarate metabolism 5
Lipid metabolism Fatty acid biosynthesis 4
Lipid metabolism Fatty acid metabolism 24
Lipid metabolism Synthesis and degradation of ketone bodies 5
Lipid metabolism Steroid biosynthesis 11
Lipid metabolism Primary bile acid biosynthesis 5
Metabolism of cofactors and vitamins Ubiquinone and other terpenoid-quinone biosynthesis 2
Lipid metabolism Steroid hormone biosynthesis 5
Energy metabolism Oxidative phosphorylation 61
Nucleotide metabolism Purine metabolism 69
Biosynthesis of other secondary metabolites Caffeine metabolism 2
Nucleotide metabolism Pyrimidine metabolism 51
Amino acid metabolism Alanine, aspartate and glutamate metabolism 19
Amino acid metabolism Glycine, serine and threonine metabolism 13
Amino acid metabolism Cysteine and methionine metabolism 18
Amino acid metabolism Valine, leucine and isoleucine degradation 28
Amino acid metabolism Valine, leucine and isoleucine biosynthesis 7
Amino acid metabolism Lysine biosynthesis 1
Amino acid metabolism Lysine degradation 31
Amino acid metabolism Arginine and proline metabolism 27
Amino acid metabolism Histidine metabolism 8
Amino acid metabolism Tyrosine metabolism 9
Amino acid metabolism Phenylalanine metabolism 5
Amino acid metabolism Tryptophan metabolism 13
Amino acid metabolism Phenylalanine, tyrosine and tryptophan biosynthesis 2
Metabolism of other amino acids beta-Alanine metabolism 10
Metabolism of other amino acids Taurine and hypotaurine metabolism 2
Metabolism of other amino acids Cyanoamino acid metabolism 3
Metabolism of other amino acids D-Glutamine and D-glutamate metabolism 2
Metabolism of other amino acids Glutathione metabolism 20
Carbohydrate metabolism Starch and sucrose metabolism 11
Glycan biosynthesis and metabolism N-Glycan biosynthesis 24
Glycan biosynthesis and metabolism Other glycan degradation 4
Carbohydrate metabolism Amino sugar and nucleotide sugar metabolism 22
Biosynthesis of other secondary metabolites Butirosin and neomycin biosynthesis 1
Glycan biosynthesis and metabolism Glycosaminoglycan degradation 9
Lipid metabolism Glycerolipid metabolism 22
Carbohydrate metabolism Inositol phosphate metabolism 25
Glycan biosynthesis and metabolism Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 10
Lipid metabolism Glycerophospholipid metabolism 29
Lipid metabolism Ether lipid metabolism 7
Lipid metabolism Arachidonic acid metabolism 13
Lipid metabolism Linoleic acid metabolism 3
Lipid metabolism alpha-Linolenic acid metabolism 4
Lipid metabolism Sphingolipid metabolism 14
Glycan biosynthesis and metabolism Glycosphingolipid biosynthesis - lacto and neolacto series 5
Glycan biosynthesis and metabolism Glycosphingolipid biosynthesis - globo series 7
Glycan biosynthesis and metabolism Glycosphingolipid biosynthesis - ganglio series 5
Carbohydrate metabolism Pyruvate metabolism 23
Carbohydrate metabolism Glyoxylate and dicarboxylate metabolism 7
Carbohydrate metabolism Propanoate metabolism 19
Carbohydrate metabolism Butanoate metabolism 18
Metabolism of cofactors and vitamins One carbon pool by folate 11
Energy metabolism Methane metabolism 5
Metabolism of cofactors and vitamins Thiamine metabolism 4
Metabolism of cofactors and vitamins Riboflavin metabolism 6
Metabolism of cofactors and vitamins Vitamin B6 metabolism 3
Metabolism of cofactors and vitamins Nicotinate and nicotinamide metabolism 10
Metabolism of cofactors and vitamins Pantothenate and CoA biosynthesis 7
Metabolism of cofactors and vitamins Folate biosynthesis 4
Metabolism of cofactors and vitamins Retinol metabolism 8
Metabolism of cofactors and vitamins Porphyrin and chlorophyll metabolism 14
Metabolism of terpenoids and polyketides Terpenoid backbone biosynthesis 7
Metabolism of terpenoids and polyketides Limonene and pinene degradation 6
Energy metabolism Nitrogen metabolism 8
Energy metabolism Sulfur metabolism 3
Xenobiotics biodegradation and metabolism Metabolism of xenobiotics by cytochrome P450 11
Xenobiotics biodegradation and metabolism Drug metabolism - cytochrome P450 10
Xenobiotics biodegradation and metabolism Drug metabolism - other enzymes 14
Lipid metabolism Biosynthesis of unsaturated fatty acids 14
Global and overview maps Metabolic pathways 460


Organismal Systems

Pathway ID Pathway Class Description #PolymiRTS
Endocrine system PPAR signaling pathway 24
Immune system Chemokine signaling pathway 81
Circulatory system Cardiac muscle contraction 32
Circulatory system Vascular smooth muscle contraction 48
Development Dorso-ventral axis formation 18
Development Axon guidance 62
Immune system Complement and coagulation cascades 8
Immune system Antigen processing and presentation 21
Endocrine system Renin-angiotensin system 7
Immune system Toll-like receptor signaling pathway 41
Immune system NOD-like receptor signaling pathway 32
Immune system RIG-I-like receptor signaling pathway 23
Immune system Cytosolic DNA-sensing pathway 16
Immune system Hematopoietic cell lineage 20
Immune system Natural killer cell mediated cytotoxicity 48
Immune system T cell receptor signaling pathway 60
Immune system B cell receptor signaling pathway 45
Immune system Fc epsilon RI signaling pathway 41
Immune system Fc gamma R-mediated phagocytosis 50
Immune system Leukocyte transendothelial migration 54
Immune system Intestinal immune network for IgA production 9
Nervous system Long-term potentiation 43
Nervous system Neurotrophin signaling pathway 98
Nervous system Long-term depression 31
Sensory system Olfactory transduction 14
Sensory system Taste transduction 7
Sensory system Phototransduction 6
Endocrine system Insulin signaling pathway 87
Endocrine system GnRH signaling pathway 48
Endocrine system Progesterone-mediated oocyte maturation 56
Endocrine system Melanogenesis 40
Endocrine system Adipocytokine signaling pathway 37
Excretory system Aldosterone-regulated sodium reabsorption 22
Excretory system Vasopressin-regulated water reabsorption 26
Excretory system Proximal tubule bicarbonate reclamation 8
Excretory system Collecting duct acid secretion 9