SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_175056
Gene Symbol: ZPLD1
Description: Homo sapiens zona pellucida-like domain containing 1 (ZPLD1), mRNA.
Gene Location: chr3(+):102153858-102198685
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr3:g.102478059C>T COSN7548603 8033610 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-204-3p ccggataTTCCCAGCttca
 1
 GCUGGGAA m8a Disrupted -0.171000 no TS 2.460000
hsa-miR-4646-5p ccggataTTCCCAGcttca
 1
 ACUGGGAA m7b Disrupted -0.162000 no TS No effect
hsa-miR-5093 ccggatATTTCCagcttca
 3
 AGGAAAUG m6b Created -0.021000 -0.021000 -2.400000
hsa-miR-875-3p ccggataTTTCCAGcttca
 0 CCUGGAAA m7b Created no TS -0.118000 -1.570000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.102478110T>C COSN5515309 RK169_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1264 tacctgAGACTTaactact
 0 CAAGUCUU m6b Created no TS -0.047000 0.090000
hsa-miR-216a taccTGAGATTtaactact
 8
 UAAUCUCA m7b Disrupted -0.091000 no TS 1.330000
hsa-miR-216b tacctGAGATTTaactact
 0 AAAUCUCU m7a Disrupted NA NA 0.010000
hsa-miR-3184-3p tacctGAGACTTaactact
 0 AAAGUCUC m7b Created no TS -0.244000 -2.410000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.102478422C>A COSN6570452 ICGC_MB53 [central_nervous_system][brain][primitive_neuroectodermal_tumour-medulloblastoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-153 gtaaCTATGCAAagattat
 0 UUGCAUAG m8a Disrupted -0.258000 -0.067000 3.240000
hsa-miR-335-3p gtaactATGAAAAgattat
 2
 UUUUUCAU m7b Created 0.073000 0.084000 0.020000
hsa-miR-3680-3p gtaactATGCAAAgattat
 8
 UUUUGCAU m7b Disrupted -0.010000 0.047000 0.560000
hsa-miR-376a-3p gtaaCTATGAaaagattat
 5
 AUCAUAGA m6b Created -0.096000 -0.134000 -0.010000
hsa-miR-376b gtaaCTATGAaaagattat
 5
 AUCAUAGA m6b Created -0.096000 -0.134000 No effect
hsa-miR-448 gtaacTATGCAAagattat
 2
 UUGCAUAU m7a Disrupted -0.040000 no TS 0.020000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.102478582T>C COSN15465411 AOCS-171-1-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-129-5p gaatctacaCAAAAAGata
 2
 CUUUUUGC m7a (m6b->m7a) 0.283000 0.283000 No effect
hsa-miR-2113 gaatctaCACAAAaagata
 0 AUUUGUGC m6b Created no TS 0.026000 No effect
hsa-miR-3668 gaaTCTACATaaaaagata
 1
 AAUGUAGA m7b (m7b->m6b) -0.141000 no TS 0.600000
hsa-miR-3924 gaatcTACATAaaaagata
 1
 AUAUGUAU m6b Disrupted 0.022000 no TS 0.040000
hsa-miR-5010-3p gaatctACACAAAAagata
 0 UUUUGUGU m8a Created no TS -0.063000 No effect
hsa-miR-599 gaatctACACAAaaagata
 0 GUUGUGUC m6b Created no TS 0.003000 -0.990000
hsa-miR-129-5p gaatctacaCAAAAAGata
 2
 CUUUUUGC m7a (m6b->m7a) 0.283000 0.283000 No effect
hsa-miR-2113 gaatctaCACAAAaagata
 0 AUUUGUGC m6b Created no TS 0.026000 No effect
hsa-miR-3668 gaaTCTACATaaaaagata
 1
 AAUGUAGA m7b (m7b->m6b) -0.141000 no TS 0.600000
hsa-miR-3924 gaatcTACATAaaaagata
 1
 AUAUGUAU m6b Disrupted 0.022000 no TS 0.040000
hsa-miR-5010-3p gaatctACACAAAAagata
 0 UUUUGUGU m8a Created no TS -0.063000 No effect
hsa-miR-599 gaatctACACAAaaagata
 0 GUUGUGUC m6b Created no TS 0.003000 -0.990000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.102478773T>G COSN8905459 SS6003121 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4511 cccatGTTCTTacaaaaaa
 4
 GAAGAACU m6b Disrupted -0.053000 -0.091000 0.020000
hsa-miR-548b-3p cccatGTTCTTacaaaaaa
 4
 CAAGAACC m6b Disrupted -0.099000 -0.114000 1.470000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.102478925A>G COSN1902269 RK052_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-105-5p ttctattcaGCATTTGtga
 0 UCAAAUGC m7b (m6c->m7b) no TS -0.033000 -0.680000
hsa-miR-409-3p ttctattCAACATTtgtga
 1
 GAAUGUUG m7b Disrupted -0.070000 -0.022000 0.010000
hsa-miR-4427 ttcTATTCAGcatttgtga
 9
 UCUGAAUA m7b (m6b->m7b) -0.128000 -0.142000 -0.840000
hsa-miR-4728-3p ttctatTCAGCATttgtga
 1
 CAUGCUGA m7b Created -0.356000 -0.470000 No effect
hsa-miR-5585-3p ttCTATTCAGcatttgtga
 5
 CUGAAUAG m8a (m7a->m8a) -0.082000 -0.035000 0.980000
hsa-miR-653 ttctaTTCAACAtttgtga
 2
 GUGUUGAA m7b Disrupted -0.085000 no TS 0.400000

Mutation Mutation ID Sample Name Cancer Type
chr3:g.102479732T>C COSN1902270 RK080_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-let-7i-3p caaaataTGCGCAaatgtt
 0 CUGCGCAA m6b Created no TS -0.316000 -2.640000
hsa-miR-507 caaaatatGTGCAAAtgtt
 11
 UUUUGCAC m7b Disrupted -0.240000 0.023000 No effect
hsa-miR-557 caaaatatGTGCAAAtgtt
 11
 GUUUGCAC m7b Disrupted -0.191000 0.026000 No effect
hsa-miR-5589-3p caaaatATGTGCAaatgtt
 0 UGCACAUG m7a Disrupted -0.169000 no TS 0.150000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
102478477 rs201477107 A A hsa-miR-5003-5p
hsa-miR-5096
hsa-miR-513b-5p
hsa-miR-627-3p
2
2
2
2
 GTTGTGAaaagag
gttGTGAAAAgag
gTTGTGAAaagag
gttgtGAAAAGAg
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.049
0.039
-0.013
0.067
C hsa-miR-507
hsa-miR-557
2
2
 gttGTGCAAAgag
gttGTGCAAAgag
 Created
Created
N
N
 -0.062
-0.081
102478772 rs17822848 C C hsa-miR-4511
hsa-miR-548b-3p
3
3
 catGTTCTTAcaa
catGTTCTTAcaa
 Disrupted
Disrupted
N
N
 0.038
0.015
A hsa-miR-2054
3
 catgtTATTACAA
 Created
N
 0.019
102478776 rs199911356 - - hsa-miR-129-5p
2
 ttcttaCAAAAAA
 Unknown
N
 0.002
A
102478968 rs141256848 T T hsa-miR-3680-3p
hsa-miR-4666b
hsa-miR-5011-3p
12
7
7
 actgcATGCAAAt
actgCATGCAAat
actgCATGCAAat
 Disrupted
Disrupted
Disrupted
N
N
N
 0.023
-0.078
-0.09
G hsa-miR-17-3p
hsa-miR-3152-5p
hsa-miR-4763-5p
hsa-miR-4774-3p
hsa-miR-6514-3p
hsa-miR-6894-3p
2
12
7
12
7
7
 ACTGCAGgcaaat
actgcAGGCAAAt
actGCAGGCAaat
actgcAGGCAAAt
actgCAGGCAAat
actGCAGGCAAat
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 -0.1
-0.063
-0.139
-0.065
-0.092
-0.286

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