SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_032679
Gene Symbol:	ZNF577
Description:	Homo sapiens zinc finger protein 577 (ZNF577), transcript variant 2, mRNA.
Gene Location:	chr19(-):52374550-52391229
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.51871386T>C			ICGC_8ECA4076-2A78-11E2-96E7-04FD496BB9B8		CPCG_0102_Pr_P_P1		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-204-3p	cctgtaaTCCCAGCacttt	0	GCUGGGAA	m7a	Created	-0.152	-0.152	No effect
hsa-miR-4663	cctgtaatCTCAGCacttt	0	AGCUGAGC	m6b	Disrupted	-0.136	no TS	0.65
hsa-miR-5089	cctgtAATCCCAgcacttt	0	GUGGGAUU	m7b	Created	no TS	-0.104	No effect
hsa-miR-5186	cctgtAATCTCagcacttt	0	AGAGAUUG	m6b	Disrupted	-0.027	no TS	No effect
hsa-miR-5589-5p	cctgtaatCCCAGCacttt	0	GGCUGGGU	m6b	Created	no TS	-0.173	-0.35

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.51871614G>C			COSN8552999		tumor_4163639		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3662	gtatgttaaCATTTTattc	0	GAAAAUGA	m6b	Created	no TS	0.027000	No effect
hsa-miR-4668-3p	gtatgttaaGATTTTattc	1	GAAAAUCC	m6b	Disrupted	-0.003000	no TS	-0.190000

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.51872470A>T			COSN8606234		1255_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1266	ttatatCCCTGAGagctca	0	CCUCAGGG	m7b	Created	no TS	-0.443000	-0.110000
hsa-miR-204-3p	ttataTCCCAGagagctca	1	GCUGGGAA	m6b	Disrupted	-0.152000	no TS	No effect
hsa-miR-211-3p	ttataTCCCTGagagctca	0	GCAGGGAC	m6b	Created	no TS	-0.161000	0.610000
hsa-miR-3191-5p	ttatatcCCAGAGAGctca	1	CUCUCUGG	m8a	Disrupted	-0.286000	-0.124000	No effect
hsa-miR-326	ttatatCCCAGAGagctca	1	CCUCUGGG	m7b	Disrupted	-0.423000	no TS	-1.200000
hsa-miR-330-5p	ttatatCCCAGAGAgctca	1	UCUCUGGG	m8a	Disrupted	-0.433000	no TS	-1.150000
hsa-miR-4314	ttataTCCCAGAGagctca	1	CUCUGGGA	m8a	Disrupted	-0.249000	no TS	No effect
hsa-miR-4441	ttataTCCCTGagagctca	0	ACAGGGAG	m6b	Created	no TS	-0.148000	No effect
hsa-miR-4518	ttatatCCCTGAGagctca	0	GCUCAGGG	m7b	Created	no TS	-0.475000	-6.320000
hsa-miR-4646-5p	ttataTCCCAGagagctca	1	ACUGGGAA	m6b	Disrupted	-0.162000	no TS	1.580000
hsa-miR-769-3p	ttatATCCCAGagagctca	0	CUGGGAUC	m7a	Disrupted	NA	NA	-2.400000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
51871598	rs188234431	C	C	hsa-miR-146a-3p hsa-miR-29a-5p hsa-miR-301a-5p hsa-miR-3191-5p hsa-miR-3920 hsa-miR-3921 hsa-miR-4653-5p	3 3 3 3 2 3 3	tataaTCAGAGAa tatAATCAGAgaa tataaTCAGAGAa tataatCAGAGAA taTAATCAGAgaa tataaTCAGAGAa tataaTCAGAGAa	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	-0.135 -0.06 -0.146 -0.124 -0.265 -0.14 -0.133
			T	hsa-miR-4684-5p hsa-miR-4735-5p hsa-miR-520f-5p hsa-miR-944	3 3 3 4	tataatTAGAGAA tatAATTAGAgaa tataaTTAGAGAa tATAATTAgagaa	Created Created Created Created	N N N N	-0.1 -0.006 -0.096 0.047

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