SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_006300
Gene Symbol: ZNF230
Description: Homo sapiens zinc finger protein 230 (ZNF230), mRNA.
Gene Location: chr19(+):44507076-44518072
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr19:g.44012103T>C COSN8973236 AOCS-166-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3908 tagtgggATTGCTagatca
 2
 GAGCAAUG m6b Disrupted -0.009000 no TS No effect
hsa-miR-3942-5p tagtgggATTGCTagatca
 2
 AAGCAAUA m6b Disrupted -0.009000 no TS 0.130000
hsa-miR-4766-3p tagtgggATTGCTAgatca
 2
 AUAGCAAU m7b Disrupted -0.009000 no TS 1.490000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.44012138G>C COSN9850848 C0085T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-147a cagaggcttCACACAagag
 0 GUGUGUGG m6b Created no TS -0.031000 -2.190000
hsa-miR-3611 cagaggCTTCACAcaagag
 2
 UUGUGAAG m7b Created -0.017000 -0.027000 No effect
hsa-miR-592 cagaggctTGACACAAgag
 0 UUGUGUCA m8a Disrupted -0.518000 -0.343000 No effect
hsa-miR-597 cagaggctTGACACAagag
 0 UGUGUCAC m7a Disrupted -0.192000 -0.133000 1.130000
hsa-miR-599 cagaggcttGACACAAgag
 0 GUUGUGUC m7b (m7b->m6c) -0.264000 -0.195000 0.120000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.44012327A>T COSN8605927 3030_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2682-3p acattaaaAAGAGGCatat
 2
 CGCCUCUU m7b Disrupted -0.271000 no TS 0.050000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.44012348C>T COSN8605928 J90_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-106a-5p taaGCACTTTagtgtgtgt
 0 AAAAGUGC m7b (m6b->m7b) no TS -0.119000 -0.060000
hsa-miR-106b-5p taaGCACTTTAgtgtgtgt
 0 UAAAGUGC m8a Created no TS -0.119000 No effect
hsa-miR-17-5p taaGCACTTTagtgtgtgt
 0 CAAAGUGC m7b (m6b->m7b) no TS -0.119000 -0.060000
hsa-miR-20a-5p taaGCACTTTAgtgtgtgt
 0 UAAAGUGC m8a Created no TS -0.119000 -0.060000
hsa-miR-20b-5p taaGCACTTTagtgtgtgt
 0 CAAAGUGC m7b (m6b->m7b) no TS -0.119000 -0.010000
hsa-miR-3609 taagCACTTTagtgtgtgt
 0 CAAAGUGA m6b Created no TS 0.021000 No effect
hsa-miR-3616-5p taagCACTTCAgtgtgtgt
 2
 AUGAAGUG m7b Disrupted -0.066000 no TS 1.040000
hsa-miR-372 taAGCACTTTagtgtgtgt
 0 AAAGUGCU m8a (m7a->m8a) -0.159000 -0.186000 No effect
hsa-miR-373-3p taAGCACTTCagtgtgtgt
 0 GAAGUGCU m8a (m8a->m7a) -0.131000 -0.158000 No effect
hsa-miR-4795-5p taagCACTTCagtgtgtgt
 2
 AGAAGUGG m6b Disrupted -0.043000 no TS No effect
hsa-miR-519a-3p taaGCACTTTagtgtgtgt
 2
 AAAGUGCA m7a (m6a->m7a) -0.008000 -0.008000 No effect
hsa-miR-519b-3p taaGCACTTTagtgtgtgt
 2
 AAAGUGCA m7a (m6a->m7a) -0.008000 -0.008000 No effect
hsa-miR-519c-3p taaGCACTTTagtgtgtgt
 2
 AAAGUGCA m7a (m6a->m7a) -0.008000 -0.008000 No effect
hsa-miR-519d taaGCACTTTagtgtgtgt
 0 CAAAGUGC m7b (m6b->m7b) no TS -0.098000 No effect
hsa-miR-520a-3p taAGCACTTTagtgtgtgt
 0 AAAGUGCU m8a (m7a->m8a) -0.140000 -0.167000 No effect
hsa-miR-520b taAGCACTTTagtgtgtgt
 0 AAAGUGCU m8a (m7a->m8a) -0.151000 -0.178000 No effect
hsa-miR-520c-3p taAGCACTTTagtgtgtgt
 0 AAAGUGCU m8a (m7a->m8a) -0.151000 -0.178000 No effect
hsa-miR-520d-3p taAGCACTTTagtgtgtgt
 0 AAAGUGCU m8a (m7a->m8a) -0.140000 -0.167000 No effect
hsa-miR-520e taAGCACTTTagtgtgtgt
 0 AAAGUGCU m8a (m7a->m8a) -0.131000 -0.158000 No effect
hsa-miR-526b-3p taaGCACTTTagtgtgtgt
 0 GAAAGUGC m7b (m6b->m7b) no TS -0.098000 No effect
hsa-miR-548ah-5p taagCACTTTagtgtgtgt
 0 AAAAGUGA m6b Created no TS 0.024000 No effect
hsa-miR-573 taagCACTTCAGtgtgtgt
 2
 CUGAAGUG m8a Disrupted -0.047000 no TS 0.030000
hsa-miR-93-5p taaGCACTTTagtgtgtgt
 0 CAAAGUGC m7b (m6b->m7b) no TS -0.119000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr19:g.44012523T>C COSN7446267 8064632 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1301 gcagtaggGCTGCAAacag
 0 UUGCAGCU m7a Created no TS -0.068000 -0.130000
hsa-miR-450b-5p gcagtagggTTGCAAAcag
 2
 UUUUGCAA m7b (m7b->m6c) -0.096000 -0.190000 0.070000
hsa-miR-4690-3p gcagtaGGGCTGCaaacag
 0 GCAGCCCA m7a Created NA NA -5.060000
hsa-miR-5047 gcagtaggGCTGCAAacag
 0 UUGCAGCU m7a Created no TS -0.068000 -0.460000
hsa-miR-652-5p gcagTAGGGTTGcaaacag
 2
 CAACCCUA m8a Disrupted -0.008000 no TS 4.740000

Mutation Mutation ID Sample Name Cancer Type
chr19:g.44012714A>G COSN6145076 RK144_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5696 atgtgtTAAATGActcaaa
 3
 CUCAUUUA m7b Disrupted 0.080000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr19:g.44013752G>A COSN1769205 RK052_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1202 tttcctCTGGCAatgaata
 5
 GUGCCAGC m6b Disrupted -0.177000 no TS -1.820000
hsa-miR-3972 tttcctCTGGCAatgaata
 5
 CUGCCAGC m6b Disrupted -0.173000 no TS 0.700000
hsa-miR-4289 tttcctctgACAATGaata
 0 GCAUUGUG m6b Created no TS -0.098000 -9.160000
hsa-miR-4317 tttcctctGGCAATGaata
 2
 ACAUUGCC m7b Disrupted -0.452000 no TS 4.460000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
44012142 rs60620675 C C hsa-miR-581
hsa-miR-592
hsa-miR-597-5p
hsa-miR-599
0 ttgACACAAGAgc
tTGACACAAgagc
tTGACACAagagc
ttGACACAAgagc
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.11
-0.175
-0.059
-0.069
44012418 rs186615201 G G hsa-miR-4652-3p
hsa-miR-4743-3p
hsa-miR-6888-3p
1
1
1
 aggACAGAAAaca
agGACAGAAAaca
agGACAGAAaaca
 Disrupted
Disrupted
Disrupted
N
N
N
 0.019
-0.097
-0.051
C hsa-miR-19a-5p
hsa-miR-19b-1-5p
hsa-miR-19b-2-5p
hsa-miR-2052
hsa-miR-2113
hsa-miR-3657
hsa-miR-4669
hsa-miR-5010-3p
hsa-miR-592
hsa-miR-599
2
2
2
2
1
1
1
1
1
1
 aggacaCAAAACA
aggacaCAAAACA
aggacaCAAAACA
aggacaCAAAACA
aggaCACAAAAca
aGGACACAaaaca
aGGACACAaaaca
aggACACAAAAca
agGACACAAaaca
agGACACAAAaca
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
 0.047
0.047
0.047
0.045
0.04
-0.119
-0.134
0.021
-0.079
-0.094

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