SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001080412
Gene Symbol:	ZBTB38
Description:	Homo sapiens zinc finger and BTB domain containing 38 (ZBTB38), mRNA.
Gene Location:	chr3(+):141043054-141168632
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.141446057A>G			COSN4893556		PCSI_0090_Pa_X		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4717-3p	attttgtCCATGTGacagt	0	ACACAUGG	m7b	Disrupted	-0.457000	-0.058000	No effect
hsa-miR-4802-3p	attttgTCCATGTgacagt	0	UACAUGGA	m7b	Disrupted	-0.214000	no TS	0.070000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.141446084A>-			ICGC_ssm_v3_105795		HCC4T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4775	agtgAAATTAAaaaaaaaa	0	UUAAUUUU	m7a	Disrupted	0.448000	0.448000	4.380000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.141447679A>T			13_257		SJMB041_D		Medulloblastoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-412	atcattGTGAAGaagtagc	0	ACUUCACC	m6b	Disrupted	0.032	no TS	11.0
hsa-miR-4731-3p	atcaTTGTGTagaagtagc	0	CACACAAG	m6b	Created	0.012	0.105	-1.81
hsa-miR-4778-3p	atcattgtGAAGAAGtagc	22	UCUUCUUC	m7b	Disrupted	0.263	0.21	1.52
hsa-miR-4801	atcaTTGTGTAgaagtagc	0	UACACAAG	m7a	Created	0.003	0.092	-0.22
hsa-miR-513b	atcaTTGTGAAgaagtagc	0	UUCACAAG	m7a	Disrupted	-0.31	-0.403	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.141448217G>C			COSN15555181		AOCS-137-1-X		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4325	ttttAAGTGCActtgtatg	5	UUGCACUU	m7b	Created	-0.259000	-0.269000	No effect
hsa-miR-4436b-5p	ttttAAGTGGACttgtatg	15	GUCCACUU	m8a	Disrupted	-0.033000	-0.004000	No effect
hsa-miR-519a-3p	ttttaagTGCACTTgtatg	2	AAAGUGCA	m7b	Created	-0.242000	-0.239000	-1.410000
hsa-miR-519b-3p	ttttaagTGCACTTgtatg	2	AAAGUGCA	m7b	Created	-0.242000	-0.239000	-0.270000
hsa-miR-519c-3p	ttttaagTGCACTTgtatg	2	AAAGUGCA	m7b	Created	-0.242000	-0.239000	-0.290000
hsa-miR-4325	ttttAAGTGCActtgtatg	5	UUGCACUU	m7b	Created	-0.259000	-0.269000	No effect
hsa-miR-4436b-5p	ttttAAGTGGACttgtatg	15	GUCCACUU	m8a	Disrupted	-0.033000	-0.004000	No effect
hsa-miR-519a-3p	ttttaagTGCACTTgtatg	2	AAAGUGCA	m7b	Created	-0.242000	-0.239000	-1.410000
hsa-miR-519b-3p	ttttaagTGCACTTgtatg	2	AAAGUGCA	m7b	Created	-0.242000	-0.239000	-0.270000
hsa-miR-519c-3p	ttttaagTGCACTTgtatg	2	AAAGUGCA	m7b	Created	-0.242000	-0.239000	-0.290000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.141449163C>T			COSN9758176		C0063T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2682-5p	taggtCTGCCTGactccaa	0	CAGGCAGU	m7a	Disrupted	-0.161000	-0.161000	0.010000
hsa-miR-4269	taggtcTGCCTGactccaa	5	GCAGGCAC	m6b	Disrupted	-0.078000	no TS	3.280000
hsa-miR-4514	taggtCTGCCTGactccaa	5	ACAGGCAG	m7b	Disrupted	-0.232000	no TS	3.270000
hsa-miR-4692	taggtCTGCCTGActccaa	5	UCAGGCAG	m8a	Disrupted	-0.253000	no TS	1.730000
hsa-miR-5702	taggtctgcCTGACTCcaa	2	UGAGUCAG	m7b	(m7b->m6c)	-0.266000	-0.192000	0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.141449379A>C			COSN1917381		RK148_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-29a-5p	gccctataAAATCAGTaaa	0	ACUGAUUU	m8a	Disrupted	-0.184000	-0.047000	0.300000
hsa-miR-3920	gccctataaAATCAGTaaa	3	ACUGAUUA	m7a	(m7a->m6b)	-0.005000	-0.005000	0.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
141446083	rs79262793	T	T	hsa-miR-4775	14	tgAAATTAAaaaa	Disrupted	N	0.031
			A	hsa-miR-205-3p	14	TGAAATAaaaaaa	Created	N	-0.042
141446717	rs186378005	T	T	hsa-miR-130a-5p hsa-miR-23a-3p hsa-miR-23b-3p hsa-miR-23c hsa-miR-4717-3p	3 3 3 3 3	agcATGTGAAtgc agcATGTGAAtgc agcATGTGAAtgc agcATGTGAAtgc agCATGTGAatgc	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.01 -0.007 -0.007 -0.007 -0.058

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