SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_133646
Gene Symbol: ZAK
Description: Homo sapiens sterile alpha motif and leucine zipper containing kinase AZK (ZAK), transcript variant 1, mRNA.
Gene Location: chr2(+):173940564-174091873
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr2:g.173221793C>G COSN15179213 SM-4AX86 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-568 tcctaTATACAatatagga
 0 AUGUAUAA m6b Disrupted -0.012000 0.044000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr2:g.173221799A>C ZAK_E12_UTR_3 SJHYPO052_R Hypodiploid_ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-337-3p atacaaTATAGGActttta
 2
 CUCCUAUA m7b Disrupted -0.191 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr2:g.173221897C>T COSN7117119 8057543 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4495 ttttaaaaaTTTACATTtt
 3
 AAUGUAAA m8a (m7b->m8a) 0.015000 -0.132000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr2:g.173222031C>T COSN15436115 AOCS-150-8-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-624-3p gtaagACCTTGTctctact
 0 CACAAGGU m7b Created no TS -0.116000 -0.010000
hsa-miR-624-3p gtaagACCTTGTctctact
 0 CACAAGGU m7b Created no TS -0.116000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.173223110G>C COSN7117120 8015858 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-146a-3p atgccccTTCAGAGGtgaa
 4
 CCUCUGAA m8a Created -0.146000 -0.040000 No effect
hsa-miR-3179 atgCCCCTTCagaggtgaa
 0 AGAAGGGG m7b (m6b->m7b) no TS -0.056000 -6.040000
hsa-miR-513c-5p atgcccCTTGAGAggtgaa
 2
 UUCUCAAG m7b Disrupted 0.126000 -0.007000 0.850000
hsa-miR-514b-5p atgcccCTTGAGAggtgaa
 2
 UUCUCAAG m7b Disrupted 0.116000 0.011000 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.173223115G>T COSN9116737 AOCS-092-3-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1305 ccttgagaGTTGAAAAata
 3
 UUUUCAAC m8a Created 0.468000 0.629000 -4.140000
hsa-miR-1306-5p ccttgaGAGGTGaaaaata
 5
 CCACCUCC m6b Disrupted 0.015000 0.021000 No effect
hsa-miR-5096 ccttgagaGGTGAAAaata
 2
 GUUUCACC m7b Disrupted 0.161000 0.096000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr2:g.173223135A>T COSN9116738 AOCS-134-3-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4724-5p cacataatGTTCAGTatgc
 6
 AACUGAAC m7b Created 0.067000 0.068000 -2.030000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.173223368T>C COSN8273852 ASHPC_0029_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1245a aaagGATCACTgtgcggat
 0 AAGUGAUC m7b Created no TS 0.034000 -0.220000
hsa-miR-128 aaaggatCACTGTGcggat
 0 UCACAGUG m7b Created no TS 0.002000 -1.570000
hsa-miR-3681-3p aaaggatCACTGTGcggat
 0 ACACAGUG m7b Created no TS -0.017000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.173223717A>G COSN1807018 RK126_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1273d aaaagATGGGTTCccccac
 0 GAACCCAU m8a Created no TS 0.053000 No effect
hsa-miR-1273d aaaagATGGGTTCccccac
 0 GAACCCAU m8a Created no TS 0.053 No effect

Mutation Mutation ID Sample Name Cancer Type
chr2:g.173225519G>A ICGC_70577EC4-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1247-3p cttgaaCCCGGGaggcaga
 1
 CCCCGGGA m6b Disrupted -0.066 no TS 5.76
hsa-miR-1343 cttgaaCCCAGGAGgcaga
 0 CUCCUGGG m8a Created 0.005 0.008 -0.64
hsa-miR-4532 cttgaaCCCGGGaggcaga
 1
 CCCCGGGG m6b Disrupted -0.058 no TS 9.72
hsa-miR-660-3p cttgaaccCAGGAGGcaga
 0 ACCUCCUG m7b Created -0.146 -0.087 -0.04

Mutation Mutation ID Sample Name Cancer Type
chr2:g.173226858T>C COSN8607997 J65_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-142-5p atcACTTTATtgttttttt
 0 CAUAAAGU m7b (m7b->m6b) 0.185000 0.253000 No effect
hsa-miR-545-5p atcacTTTACTGttttttt
 6
 UCAGUAAA m7b Created 0.014000 -0.111000 No effect
hsa-miR-5590-3p atcACTTTATTgttttttt
 0 AAUAAAGU m8a Disrupted 0.222000 0.300000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
173222498 rs77431903 - C hsa-miR-3149
hsa-miR-568
hsa-miR-6844
6
4
5
 tttATACAAAgag
tTTATACAAagag
tttatACAAAGAg
 Unknown
Unknown
Unknown
N
N
N
 0.093
0.032
-0.027
T hsa-miR-190a-3p
hsa-miR-410-3p
hsa-miR-6083
4
5
6
 ttTATATAAagag
tTTATATAaagag
tttATATAAAgag
 Unknown
Unknown
Unknown
N
N
N
 0.143
0.133
0.133
173222499 rs138772418 - A hsa-miR-130b-5p
hsa-miR-3149
hsa-miR-4753-3p
hsa-miR-568
hsa-miR-6844
6
6
6
4
5
 ttatacAAAGAGA
ttATACAAAgaga
ttatacAAAGAGA
TTATACAAagaga
ttatACAAAGAga
 Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
 No Change
0.093
-0.017
0.032
-0.027
G hsa-miR-1236-3p
hsa-miR-6515-3p
6
6
 ttatacGAAGAGA
ttatacGAAGAGA
 Unknown
Unknown
N
N
 -0.002
-0.006
173224648 rs139080666 T C hsa-miR-151a-5p
hsa-miR-151b
hsa-miR-3150b-3p
hsa-miR-4784
0 tCTCCTCGtagaa
tCTCCTCGtagaa
TCTCCTCgtagaa
TCTCCTCgtagaa
 Created
Created
Created
Created
N
N
N
N
 -0.164
-0.164
-0.025
-0.007
T hsa-miR-1283
hsa-miR-4428
hsa-miR-624-3p
1
1
0
 tctccTTGTAGAa
TCTCCTTgtagaa
tctCCTTGTAgaa
 Disrupted
Disrupted
Disrupted
N
N
N
 0.095
0.003
0.032

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