SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001100118
Gene Symbol:	XRCC3
Description:	Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 3 (XRCC3), transcript variant 3, mRNA.
Gene Location:	chr14(-):104163953-104181823
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.103697862G>C			COSN1164637		HX14T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1184	tcccacactCTGCAGaccc	2	CCUGCAGC	m6b	Created	-0.029000	-0.072000	No effect
hsa-miR-128	tcccaCACTGTGcagaccc	1	UCACAGUG	m7b	Disrupted	-0.202000	-0.123000	-0.660000
hsa-miR-17-3p	tcccacactCTGCAGaccc	0	ACUGCAGU	m6b	Created	no TS	-0.050000	-0.390000
hsa-miR-2467-3p	tcccacaCTCTGCagaccc	0	AGCAGAGG	m6b	Created	no TS	-0.058000	No effect
hsa-miR-3130-3p	tcccacactGTGCAGaccc	0	GCUGCACC	m6b	Disrupted	-0.096000	no TS	No effect
hsa-miR-3158-5p	tcccacacTCTGCAGaccc	0	CCUGCAGA	m7b	Created	no TS	-0.188000	-1.520000
hsa-miR-3678-3p	tcccacaCTCTGCAGaccc	0	CUGCAGAG	m8a	Created	no TS	-0.112000	-5.930000
hsa-miR-3681-3p	tcccaCACTGTGcagaccc	1	ACACAGUG	m7b	Disrupted	-0.147000	-0.077000	No effect
hsa-miR-4302	tccCACACTGtgcagaccc	1	CCAGUGUG	m7b	(m7b->m6c)	-0.143000	-0.089000	-0.010000
hsa-miR-574-5p	tccCACACTCtgcagaccc	0	UGAGUGUG	m7b	(m6c->m7b)	no TS	-0.078000	No effect
hsa-miR-759	tcccaCACTCTGCagaccc	0	GCAGAGUG	m8a	Created	no TS	-0.085000	7.830000
hsa-miR-1184	tcccacactCTGCAGaccc	0	CCUGCAGC	m6b	Created	-0.029	-0.072	No effect
hsa-miR-128	tcccaCACTGTGcagaccc	0	UCACAGUG	m7b	Disrupted	-0.202	-0.123	-0.66
hsa-miR-17-3p	tcccacactCTGCAGaccc	0	ACUGCAGU	m6b	Created	no TS	-0.05	-0.39
hsa-miR-2467-3p	tcccacaCTCTGCagaccc	0	AGCAGAGG	m6b	Created	no TS	-0.058	No effect
hsa-miR-3130-3p	tcccacactGTGCAGaccc	0	GCUGCACC	m6b	Disrupted	-0.096	no TS	No effect
hsa-miR-3158-5p	tcccacacTCTGCAGaccc	0	CCUGCAGA	m7b	Created	no TS	-0.188	-1.52
hsa-miR-3678-3p	tcccacaCTCTGCAGaccc	0	CUGCAGAG	m8a	Created	no TS	-0.112	-5.93
hsa-miR-3681-3p	tcccaCACTGTGcagaccc	0	ACACAGUG	m7b	Disrupted	-0.147	-0.077	No effect
hsa-miR-4302	tccCACACTGtgcagaccc	0	CCAGUGUG	m7b	(m7b->m6c)	-0.143	-0.089	-0.01
hsa-miR-574-5p	tccCACACTCtgcagaccc	0	UGAGUGUG	m7b	(m6c->m7b)	no TS	-0.078	No effect
hsa-miR-759	tcccaCACTCTGCagaccc	0	GCAGAGUG	m8a	Created	no TS	-0.085	7.83

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
103697843	rs186232444	-	C	hsa-miR-128-3p hsa-miR-216a-3p hsa-miR-3681-3p hsa-miR-4302	1 1 1 1	cccaCACTGTGgc cccaCACTGTGgc cccaCACTGTGgc ccCACACTGtggc	Unknown Unknown Unknown Unknown	N N N N	-0.097 -0.116 -0.051 -0.04
			G	hsa-miR-134-3p hsa-miR-4318	1 1	CCCACAGtgtggc cCCACAGTgtggc	Unknown Unknown	N N	-0.161 -0.091
103698233	rs140813869	C	C	hsa-miR-3151-5p hsa-miR-4447 hsa-miR-4472 hsa-miR-486-3p hsa-miR-491-5p hsa-miR-6742-5p hsa-miR-6796-5p	3 4 4 2 4 4 4	actgtGCCCCACA actgtgCCCCACA actgtgCCCCACA actgTGCCCCAca actgtgCCCCACA actgtgCCCCACA actgtgCCCCACA	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	-0.357 -0.136 -0.136 -0.128 -0.124 -0.133 -0.192
			A	hsa-miR-128-3p hsa-miR-216a-3p hsa-miR-27a-3p hsa-miR-27b-3p hsa-miR-3681-3p hsa-miR-6748-5p hsa-miR-6759-5p hsa-miR-6793-5p	1 1 1 1 1 4 4 4	ACTGTGAcccaca ACTGTGAcccaca ACTGTGAcccaca ACTGTGAcccaca ACTGTGAcccaca actgtgACCCACA actgtgACCCACA actgtgACCCACA	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.109 -0.109 0.02 0.02 -0.109 -0.109 -0.153 -0.126

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