SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_005431
Gene Symbol: XRCC2
Description: Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 2 (XRCC2), mRNA.
Gene Location: chr7(-):152343586-152373250
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr7:g.152646516C>T COSN14712590 CHC322T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1295b-5p ccgcCTGGGTGactccatc
 1
 CACCCAGA m7a Created -0.162000 -0.162000 -0.140000
hsa-miR-1295b-5p ccgcCTGGGTGactccatc
 1
 CACCCAGA m7a Created -0.162000 -0.162000 -0.140000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.152646745T>C ICGC_7E46B5F4-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-204-3p ctgtgaTCCCAGCactttg
 0 GCUGGGAA m7a Created NA NA No effect
hsa-miR-450b-3p ctgtGATCCCAgcactttg
 0 UUGGGAUC m7b Created no TS -0.172 -2.13
hsa-miR-4661-3p ctgtGATCCTagcactttg
 0 CAGGAUCC m6b Disrupted -0.275 -0.182 0.73
hsa-miR-512-3p ctgtgatccCAGCACTTtg
 0 AAGUGCUG m8a (m7a->m8a) -0.077 -0.16 -0.02
hsa-miR-5589-5p ctgtgatCCCAGCactttg
 0 GGCUGGGU m6b Created -0.654 -0.778 No effect
hsa-miR-638 ctgtGATCCCagcactttg
 0 AGGGAUCG m6b Created no TS -0.136 -1.64
hsa-miR-769-3p ctgtGATCCCAGcactttg
 0 CUGGGAUC m8a Created no TS -0.144 -0.14

Mutation Mutation ID Sample Name Cancer Type
chr7:g.152647094G>C COSN9936980 C0023T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1256 gtccaAATGCCTattataa
 0 AGGCAUUG m7a Created NA NA -7.710000
hsa-miR-1295b-3p gtccaaatGCCTATTataa
 0 AAUAGGCC m7a Created NA NA -5.480000

Mutation Mutation ID Sample Name Cancer Type
chr7:g.152647133G>A ICGC_7E46BAC2-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-19a-5p atgcaaatCAAAACaacaa
 0 AGUUUUGC m6b Created 0.1 0.095 -0.73
hsa-miR-19b-1-5p atgcaaatCAAAACaacaa
 0 AGUUUUGC m6b Created 0.09 0.078 -0.13
hsa-miR-19b-2-5p atgcaaatCAAAACaacaa
 0 AGUUUUGC m6b Created 0.09 0.068 -5.51
hsa-miR-2052 atgcaaaTCAAAACAacaa
 0 UGUUUUGA m8a Created 0.095 0 -0.39
hsa-miR-5705 atgcaaatCGAAACAacaa
 0 UGUUUCGG m7a Disrupted -0.144 no TS 5

Mutation Mutation ID Sample Name Cancer Type
chr7:g.152647210T>C ICGC_A3875698-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1253 cagacaCTTCTCaaaagaa
 0 AGAGAAGA m6b Created no TS -0.026 -6.65
hsa-miR-548t-5p cagaCACTTTTcaaaagaa
 0 CAAAAGUG m7b Disrupted 0.043 0.048 1.44
hsa-miR-580 cagacacTTCTCAAaagaa
 0 UUGAGAAU m7a Created no TS -0.025 -0.06

Mutation Mutation ID Sample Name Cancer Type
chr7:g.152647417C>G ICGC_7E46BF90-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1257 gcaaaaATTCACaaatggg
 0 AGUGAAUG m6b Disrupted -0.026 no TS 9.49
hsa-miR-183-3p gcaaaAATTCACaaatggg
 0 GUGAAUUA m7a Disrupted NA NA No effect
hsa-miR-3611 gcaaaaaTTCACAAatggg
 0 UUGUGAAG m7a Disrupted -0.281 -0.261 0.17


Mutation Mutation ID Sample Name Cancer Type
chr7:g.152647637C>A COSN2210633 RK046_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr7:g.152647658T>A ICGC_A3875BB6-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3121-5p aatggGCAAAGGAttctct
 0 UCCUUUGC m8a Created -0.321 -0.436 -2.4
hsa-miR-4317 aatgGGCAATGgattctct
 0 ACAUUGCC m7b Disrupted -0.112 no TS -0.01
hsa-miR-500a-5p aatgggcaAAGGATTctct
 0 UAAUCCUU m7b Created 0.004 0.005 No effect
hsa-miR-501-5p aatgggcAAAGGATTctct
 0 AAUCCUUU m8a Created no TS 0.043 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.152647661C>G ICGC_A38760F2-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2355-5p agcaaTGGGGAatggattc
 0 AUCCCCAG m6b Created no TS -0.073 -0.01
hsa-miR-4317 agcaatgGGCAATGgattc
 0 ACAUUGCC m7b Disrupted -0.112 no TS 1.77
hsa-miR-4641 agcaATGGGCAatggattc
 0 UGCCCAUG m7a Disrupted -0.103 no TS 1.34

Mutation Mutation ID Sample Name Cancer Type
chr7:g.152647819G>A ICGC_7E46C45E-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-127-5p cgctacccAGCTTCAaact
 0 CUGAAGCU m7b Disrupted -0.1 no TS No effect
hsa-miR-320e cgctacCCAGCTTcaaact
 0 AAAGCUGG m7b Disrupted -0.103 -0.024 No effect
hsa-miR-3616-5p cgctacccaACTTCAaact
 0 AUGAAGUG m6b Created no TS 0.004 -0.04
hsa-miR-382-5p cgctaccCAACTTCaaact
 0 GAAGUUGU m7a Created NA NA -0.02
hsa-miR-4259 cgctaCCCAACTtcaaact
 0 CAGUUGGG m7b Created no TS -0.145 No effect
hsa-miR-4670-3p cgctacccAACTTCAaact
 0 UGAAGUUA m7a Created no TS 0.017 -0.03
hsa-miR-5589-5p cgctACCCAGCttcaaact
 0 GGCUGGGU m7b Disrupted -0.654 -0.513 No effect
hsa-miR-573 cgctacccaACTTCAaact
 0 CUGAAGUG m6b Created no TS 0.004 -0.62

Mutation Mutation ID Sample Name Cancer Type
chr7:g.152647820A>G ICGC_7E46C936-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-127-5p acgctacccAGCTTCAaac
 0 CUGAAGCU m7b (m7b->m6b) -0.1 -0.032 -0.01
hsa-miR-320e acgctacCCAGCTTcaaac
 0 AAAGCUGG m7b Disrupted -0.103 -0.024 No effect
hsa-miR-4786-3p acgctacccGGCTTCAaac
 0 UGAAGCCA m7a (m6a->m7a) no TS -0.068 -0.01
hsa-miR-5589-5p acgctACCCAGCttcaaac
 0 GGCUGGGU m7b Disrupted -0.654 -0.513 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.152647821C>T ICGC_7E46CE04-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-197-5p cacgCTACCCagcttcaaa
 0 CGGGUAGA m6b Disrupted -0.089 no TS No effect
hsa-miR-320e cacgctacCCAGCTTcaaa
 0 AAAGCUGG m7b Disrupted -0.103 -0.024 No effect
hsa-miR-3927 cacgCTACCTagcttcaaa
 0 CAGGUAGA m6b Created no TS -0.056 No effect
hsa-miR-5589-5p cacgctACCCAGCttcaaa
 0 GGCUGGGU m7b Disrupted -0.654 -0.513 No effect

Mutation Mutation ID Sample Name Cancer Type
chr7:g.152648243A>G ICGC_7E46D2D2-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4477a gtatttTTAATAGagacgg
 0 CUAUUAAG m7a Disrupted NA NA No effect
hsa-miR-4684-5p gtatttttaGTAGAGAcgg
 0 CUCUCUAC m7b (m6b->m7b) -0.054 -0.171 -1.22

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
152647129 rs143592960 C C hsa-miR-5705
1
 tCGAAACAacaac
 Disrupted
N
 -0.144
152647164 rs146290715 A A hsa-miR-27a-5p
hsa-miR-378g
hsa-miR-4731-5p
hsa-miR-5589-5p
1
1
1
1
 AAGCCCAgcatca
aAGCCCAGcatca
aagCCCAGCAtca
aagCCCAGCAtca
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.112
-0.199
-0.135
-0.142
152647166 rs112877960 C C hsa-miR-27a-5p
hsa-miR-3119
hsa-miR-378g
hsa-miR-4731-5p
hsa-miR-5589-5p
1
1
1
1
1
 aaAAGCCCAgcat
AAAAGCCcagcat
aaaAGCCCAGcat
aaaagCCCAGCAt
aaaagCCCAGCAt
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.112
-0.08
-0.199
-0.135
-0.142
T hsa-miR-208a-5p
hsa-miR-208b-5p
hsa-miR-27b-5p
hsa-miR-4663
hsa-miR-4728-3p
hsa-miR-7160-5p
hsa-miR-8077
1
1
1
1
1
1
1
 AAAAGCTcagcat
AAAAGCTcagcat
aaAAGCTCAgcat
aaaaGCTCAGCAt
aaaagcTCAGCAT
aaaagCTCAGCAt
aaaagCTCAGCAt
 Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
 -0.036
-0.036
-0.082
-0.349
-0.088
-0.081
-0.125
152647399 rs111907081 A
C hsa-miR-183-3p
hsa-miR-4452
1
1
 cTAATTCAActaa
ctAATTCAActaa
 Created
Created
N
N
 0.088
0.069

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