SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000380
Gene Symbol: XPA
Description: Homo sapiens xeroderma pigmentosum, complementation group A (XPA), transcript variant 1, mRNA.
Gene Location: chr9(-):100437190-100459691
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Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr9:g.97675017C>T COSN9690668 AOCS-091-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4643 ggttctagtCATGTGTttt
2
GACACAUG m7b (m7b->m6b) -0.176000 no TS 0.130000
hsa-miR-4789-3p ggttctagtTATGTGTttt
0 CACACAUA m7b (m6b->m7b) no TS -0.129000 -4.780000
hsa-miR-708-3p ggtTCTAGTTatgtgtttt
0 CAACUAGA m7b (m6c->m7b) no TS -0.256000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr9:g.97675344C>T COSN1370516 HCC14T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3662 aagcaaCATTTTCatagat
0 GAAAAUGA m7a Created NA NA -4.460000
hsa-miR-409-3p aagCAACATTttcatagat
0 GAAUGUUG m7b (m6c->m7b) no TS -0.153000 -1.720000
hsa-miR-4426 aagcaaCATCTTCatagat
0 GAAGAUGG m7a Disrupted NA NA 0.320000
hsa-miR-4647 aagcaaCATCTTCatagat
0 GAAGAUGG m7a Disrupted NA NA 0.970000
hsa-miR-4699-5p aagcaacATCTTCatagat
2
AGAAGAUU m6b Disrupted -0.114000 no TS 1.920000
hsa-miR-3662 aagcaaCATTTTCatagat
0 GAAAAUGA m7a Created NA NA -4.460000
hsa-miR-409-3p aagCAACATTttcatagat
0 GAAUGUUG m7b (m6c->m7b) no TS -0.153000 -1.720000
hsa-miR-4426 aagcaaCATCTTCatagat
0 GAAGAUGG m7a Disrupted NA NA 0.320000
hsa-miR-4647 aagcaaCATCTTCatagat
0 GAAGAUGG m7a Disrupted NA NA 0.970000
hsa-miR-4699-5p aagcaacATCTTCatagat
2
AGAAGAUU m6b Disrupted -0.114000 no TS 1.920000
hsa-miR-3662 aagcaaCATTTTCatagat
0 GAAAAUGA m7a Created NA NA -4.46
hsa-miR-409-3p aagCAACATTttcatagat
0 GAAUGUUG m7b (m6c->m7b) no TS -0.153 -1.72
hsa-miR-4426 aagcaaCATCTTCatagat
0 GAAGAUGG m7a Disrupted NA NA 0.32
hsa-miR-4647 aagcaaCATCTTCatagat
0 GAAGAUGG m7a Disrupted NA NA 0.97
hsa-miR-4699-5p aagcaacATCTTCatagat
0 AGAAGAUU m6b Disrupted -0.114 no TS 1.92

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
97675011 rs143474170 T T hsa-miR-4643
2
CATGTGTttttta
Disrupted
N
-0.176
C hsa-miR-548e-5p
hsa-miR-5589-3p
hsa-miR-6835-3p
2
2
2
catgTGCTTTTta
CATGTGCttttta
catGTGCTTTtta
Created
Created
Created
N
N
N
-0.036
-0.257
-0.162

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