SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_016373
Gene Symbol:	WWOX
Description:	Homo sapiens WW domain containing oxidoreductase (WWOX), transcript variant 1, mRNA.
Gene Location:	chr16(+):78133326-79246564
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.79211976->GTAAA			ICGC_1419479		TCGA-AX-A2H5-01A-11D-A17D-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.79212181G>A			COSN15322509		SNUH_G76_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3064-5p	actgCAGCCAGgggctggc	0	UCUGGCUG	m7b	Created	-0.139000	-0.254000	-1.200000
hsa-miR-331-3p	actgcagCCAGGGGCtggc	0	GCCCCUGG	m8a	Created	no TS	-0.130000	No effect
hsa-miR-3943	actgcagccGGGGGCTggc	1	UAGCCCCC	m7b	(m7b->m6c)	-0.156000	no TS	2.770000
hsa-miR-4707-5p	actgcaGCCGGGGgctggc	1	GCCCCGGC	m7b	Disrupted	-0.259000	no TS	7.130000
hsa-miR-647	actGCAGCCAggggctggc	0	GUGGCUGC	m7b	(m6b->m7b)	no TS	-0.105000	-0.160000

Mutation			Mutation ID		Sample Name		Cancer Type
chr16:g.79212293A>G			COSN5267685		SNUH_G79_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-192-3p	agccagcTTGGCAactgct	0	CUGCCAAU	m6b	Created	no TS	-0.072000	-0.010000
hsa-miR-4480	agccagCTTGGCaactgct	0	AGCCAAGU	m6b	Created	no TS	-0.108000	-6.250000
hsa-miR-4639-5p	agccagCTTAGCAActgct	0	UUGCUAAG	m8a	Disrupted	-0.190000	no TS	2.910000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
79211996	rs144412859	-	GGGCT		0
			-	hsa-miR-3943 hsa-miR-4323 hsa-miR-6769a-3p	9 9 9	cacttttctGGGGCTA cacttttcTGGGGCTA cacttttctGGGGCTA	Unknown Unknown Unknown	N N N	-0.2 -0.216 -0.187
79212181	rs2288032	G	G	hsa-miR-3943 hsa-miR-4707-5p hsa-miR-6840-5p	1 1 1	gcagccGGGGGCT gcaGCCGGGGgct gcagCCGGGGGct	Disrupted Disrupted Disrupted	N N N	-0.156 -0.259 -0.242
			A	hsa-miR-210-5p hsa-miR-3064-5p hsa-miR-331-3p hsa-miR-604 hsa-miR-647 hsa-miR-6504-5p hsa-miR-6762-3p hsa-miR-6769a-3p	1 1 1 1 1 1 1 1	gcagcCAGGGGCt gCAGCCAGgggct gcagCCAGGGGct GCAGCCAggggct GCAGCCAggggct gCAGCCAGgggct GCAGCCAggggct gcagccAGGGGCT	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.142 -0.115 -0.13 -0.115 -0.105 -0.059 -0.109 -0.125
79212293	rs1126520	G	A	hsa-miR-320e hsa-miR-4639-5p	0	CAGCTTAgcaact cagCTTAGCAAct	Created Created	N N	-0.15 -0.19
			G	hsa-miR-192-3p hsa-miR-4480 hsa-miR-6501-5p	1 0 1	cagcTTGGCAAct cagCTTGGCAact cagctTGGCAACt	Disrupted Disrupted Disrupted	N N N	-0.072 -0.108 -0.157

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