SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_015253
Gene Symbol:	WSCD1
Description:	Homo sapiens WSC domain containing 1 (WSCD1), mRNA.
Gene Location:	chr17(+):5973933-6027747
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.6120764G>A			COSN1199531		BN05T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1208	gggacgAACAGTGggtggg	0	UCACUGUU	m7b	Created	no TS	-0.015000	-0.050000
hsa-miR-1280	gggacgaaCGGTGGGtggg	1	UCCCACCG	m7b	Disrupted	-0.231000	-0.023000	No effect
hsa-miR-1208	gggacgAACAGTGggtggg	0	UCACUGUU	m7b	Created	no TS	-0.015	-0.05
hsa-miR-1280	gggacgaaCGGTGGGtggg	0	UCCCACCG	m7b	Disrupted	-0.231	-0.023	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.6120947G>T			10_18906		6408		Breast cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-662	acccACGTGGGgtgtgcca	5	UCCCACGU	m7b	Disrupted	-0.342	-0.158	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.6120968A>C			COSN6108777		RK155_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3126-3p	cacccCCAGATacaaatgc	0	CAUCUGGC	m6b	Disrupted	-0.076000	no TS	-0.070000
hsa-miR-3674	cacccccagCTACAAatgc	0	AUUGUAGA	m6b	Created	no TS	-0.008000	No effect
hsa-miR-4731-5p	cacCCCCAGCtacaaatgc	4	UGCUGGGG	m7b	(m6b->m7b)	-0.133000	-0.297000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.6121154G>A			COSN8244886		PCSI_0083_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1254	tgctgggCCAGGCagacat	0	AGCCUGGA	m6b	Created	-0.283000	-0.391000	-0.020000
hsa-miR-18a-3p	tgctgggccGGGCAGacat	2	ACUGCCCU	m6b	Disrupted	-0.245000	-0.135000	No effect
hsa-miR-324-3p	tgctgggccGGGCAGacat	2	ACUGCCCC	m6b	Disrupted	-0.140000	-0.035000	No effect
hsa-miR-5001-3p	tgctgggccAGGCAGAcat	0	UUCUGCCU	m7b	(m6c->m7b)	-0.386000	-0.497000	-0.930000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.6121804G>A			COSN6659181		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-454-5p	gcctggGATAGGGgtcaat	2	ACCCUAUC	m7b	Created	-0.095000	-0.103000	No effect
hsa-miR-5195-5p	gcctgggaTAGGGGTcaat	0	AACCCCUA	m7b	Created	no TS	-0.105000	No effect
hsa-miR-454-5p	gcctggGATAGGGgtcaat	2	ACCCUAUC	m7b	Created	-0.095000	-0.103000	No effect
hsa-miR-5195-5p	gcctgggaTAGGGGTcaat	0	AACCCCUA	m7b	Created	no TS	-0.105000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.6121931G>T			COSN5221133		SS6003323		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4668-3p	gggaGGATTTTggcgatcc	0	GAAAAUCC	m7b	Created	no TS	0.180000	1.250000
hsa-miR-4668-3p	gggaGGATTTTggcgatcc	0	GAAAAUCC	m7b	Created	no TS	0.180000	1.250000

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.6123068G>C			COSN7441991		8031121		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3124-3p	tgcAGGAAAGTccatttgt	4	ACUUUCCU	m8a	Disrupted	0.113000	no TS	No effect
hsa-miR-5009-5p	tgcaggaAAGTCCAtttgt	10	UUGGACUU	m7b	Disrupted	-0.025000	no TS	0.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
6120968	rs3087809	A	A	hsa-miR-1298-3p hsa-miR-3126-3p hsa-miR-3149 hsa-miR-4667-5p hsa-miR-4700-5p hsa-miR-637 hsa-miR-7155-5p hsa-miR-8089	2 2 2 2 2 2 2 2	cCCCAGATAcaaa ccCCAGATAcaaa ccccagATACAAA CCCCAGAtacaaa CCCCAGAtacaaa CCCCAGAtacaaa CCCCAGAtacaaa CCCCAGAtacaaa	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N	-0.255 -0.076 0.038 -0.135 -0.138 -0.201 -0.149 -0.135
			C	hsa-miR-3674 hsa-miR-4731-5p	2 2	ccccagCTACAAA CCCCAGCtacaaa	Created Created	N N	-0.008 -0.164
6121804	rs7210135	G	G	hsa-miR-6859-3p	3	tgggatGGGGGTC	Disrupted	N	-0.184
			A	hsa-miR-454-5p hsa-miR-4733-5p hsa-miR-5195-5p hsa-miR-6846-3p	2 2 2 3	tggGATAGGGgtc TGGGATAggggtc tgggaTAGGGGTc tgggatAGGGGTC	Created Created Created Created	N N N N	-0.008 0.02 -0.105 -0.118
6122841	rs183483175	G	G	hsa-miR-412-3p hsa-miR-6515-3p hsa-miR-6754-3p hsa-miR-6837-3p hsa-miR-7703	2 2 2 2 2	aGTGAAGAgtgca agTGAAGAGtgca aGTGAAGAgtgca AGTGAAGAgtgca agtgaaGAGTGCA	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	0.083 0.127 0.09 0.148 0.008
			C	hsa-miR-1208	2	agtgAACAGTGca	Created	N	0.101
6123013	rs41314089	A	A	hsa-miR-1910-3p hsa-miR-2682-5p hsa-miR-34b-5p hsa-miR-449c-5p hsa-miR-6511a-5p hsa-miR-662 hsa-miR-6806-5p hsa-miR-6808-5p hsa-miR-6893-5p hsa-miR-940	2 2 2 2 2 1 2 2 2 2	CTGCCTAcgtggg CTGCCTAcgtggg CTGCCTAcgtggg CTGCCTAcgtggg CTGCCTAcgtggg ctgcctACGTGGG cTGCCTACgtggg CTGCCTAcgtggg CTGCCTAcgtggg CTGCCTAcgtggg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N	-0.041 0.032 0.035 0.032 -0.036 -0.087 0.017 0.047 0.057 0.071
			G	hsa-miR-4514 hsa-miR-4692	2 2	CTGCCTGcgtggg CTGCCTGcgtggg	Created Created	N N	0.011 0.02
6123014	rs191759066	C	C	hsa-miR-662 hsa-miR-6806-5p	1 2	tgcctACGTGGGA TGCCTACgtggga	Disrupted Disrupted	N N	-0.159 0.017
			T	hsa-miR-188-3p	1	tgcctaTGTGGGA	Created	N	-0.03

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