SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_030761
Gene Symbol:	WNT4
Description:	Homo sapiens wingless-type MMTV integration site family, member 4 (WNT4), mRNA.
Gene Location:	chr1(-):22443797-22469519
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Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.22117364T>C			COSN9025172		8051719		[pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-128	tctttgcCACTGTGAcgtc	0	UCACAGUG	m8a	Created	no TS	-0.255000	-1.660000
hsa-miR-27a-3p	tctttgccACTGTGAcgtc	0	UUCACAGU	m7b	Created	no TS	-0.101000	-1.670000
hsa-miR-27b-3p	tctttgccACTGTGAcgtc	0	UUCACAGU	m7b	Created	no TS	-0.101000	-1.670000
hsa-miR-3681-3p	tctttgcCACTGTGacgtc	0	ACACAGUG	m7b	Created	no TS	-0.265000	-0.060000
hsa-miR-3688-5p	tctTTGCCACTgtgacgtc	0	AGUGGCAA	m8a	Created	no TS	-0.198000	-1.780000
hsa-miR-5197-5p	tcttTGCCATTGtgacgtc	6	CAAUGGCA	m8a	Disrupted	-0.177000	no TS	0.010000
hsa-miR-5693	tctttGCCACTGtgacgtc	2	GCAGUGGC	m7b	Created	-0.652000	-0.903000	-0.050000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.22117844G>C			COSN15076881		SM-4B296		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-130b-5p	cagagGAAAGAGctgagcc	1	ACUCUUUC	m7b	Disrupted	0.039000	0.003000	No effect
hsa-miR-3124-3p	cagAGGAAAGagctgagcc	1	ACUUUCCU	m7b	(m7b->m6c)	0.300000	0.302000	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.22117964G>A			COSN8435767		AOCS-128-1-0		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4519	gctgggtcCACTGCTcccc	0	CAGCAGUG	m7b	Created	no TS	-0.018000	-0.480000
hsa-miR-4800-5p	gctgGGTCCACTgctcccc	3	AGUGGACC	m8a	Created	-0.389000	-0.487000	-0.010000
hsa-miR-503	gctgggtcCGCTGCTcccc	0	UAGCAGCG	m7b	Disrupted	-0.233000	-0.163000	1.830000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.22118111C>A			COSN7205792		8043983		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4756-3p	agccaagATCTCTGctcaa	2	CCAGAGAU	m7b	Disrupted	0.014000	no TS	0.490000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
22117369	rs141883380	T	T	hsa-miR-1276 hsa-miR-4470 hsa-miR-5197-5p	2 2 12	GCTCTTTgccatt gctcTTTGCCAtt gctcttTGCCATT	Disrupted Disrupted Disrupted	N N N	-0.099 -0.113 -0.177
			G	hsa-miR-335-5p hsa-miR-3926 hsa-miR-548s	2 2 2	GCTCTTGgccatt gctcTTGGCCAtt gctcTTGGCCAtt	Created Created Created	N N N	-0.179 -0.166 -0.191
22118711	rs182098512	G	G	hsa-miR-2115-5p hsa-miR-516a-3p hsa-miR-516b-3p hsa-miR-670-5p hsa-miR-6752-3p hsa-miR-7162-5p	5 5 5 4 3 5	ggcagGGAAGCAg ggcagGGAAGCAg ggcagGGAAGCAg ggCAGGGAAgcag GGCAGGGAagcag ggcagGGAAGCAg	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	0.028 0.048 0.048 0.039 -0.083 0.041
			A	hsa-miR-3074-5p hsa-miR-3124-3p hsa-miR-3160-5p hsa-miR-4722-3p hsa-miR-6727-3p hsa-miR-6747-3p hsa-miR-7152-5p	3 3 5 3 3 3 4	gGCAGGAAAgcag ggcAGGAAAGcag ggcagGAAAGCAg GGCAGGAaagcag GGCAGGAaagcag GGCAGGAaagcag ggCAGGAAAgcag	Created Created Created Created Created Created Created	N N N N N N N	0.084 0.147 0.097 -0.03 -0.03 -0.018 0.098

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