SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_014688
Gene Symbol:	USP6NL
Description:	Homo sapiens USP6 N-terminal like (USP6NL), transcript variant 2, mRNA.
Gene Location:	chr10(-):11502508-11653679
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.11460606C>T			COSN6961329		8016470		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-223-5p	atatatATACACacaagca	4	CGUGUAUU	m6b	Disrupted	-0.118000	-0.126000	-0.080000
hsa-miR-5011-5p	ataTATATATAcacaagca	5	UAUAUAUA	m8a	Created	-2.904000	-3.126000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.11460656T>A			COSN8639063		3030_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-410	tgtagatttTTATATatat	0	AAUAUAAC	m6b	Disrupted	0.010000	0.019000	-0.430000
hsa-miR-5011-5p	tgtagattTATATATAtat	5	UAUAUAUA	m8a	Created	-2.904000	-3.076000	0.010000
hsa-miR-548c-3p	tgtaGATTTTTatatatat	7	CAAAAAUC	m7b	Disrupted	0.070000	0.217000	0.230000
hsa-miR-410	tgtagatttTTATATatat	0	AAUAUAAC	m6b	Disrupted	0.010000	0.019000	-0.430000
hsa-miR-5011-5p	tgtagattTATATATAtat	5	UAUAUAUA	m8a	Created	-2.904000	-3.076000	0.010000
hsa-miR-548c-3p	tgtaGATTTTTatatatat	7	CAAAAAUC	m7b	Disrupted	0.070000	0.217000	0.230000
hsa-miR-410	tgtagatttTTATATatat	0	AAUAUAAC	m6b	Disrupted	0.01	0.019	-0.43
hsa-miR-5011-5p	tgtagattTATATATAtat	0	UAUAUAUA	m8a	Created	-2.904	-3.076	0.01
hsa-miR-548c-3p	tgtaGATTTTTatatatat	0	CAAAAAUC	m7b	Disrupted	0.07	0.217	0.23

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.11461393C>T			COSN1471848		RK089_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-18a-5p	gctGCACCTTAtcaggcca	0	UAAGGUGC	m8a	Created	no TS	-0.212000	-1.160000
hsa-miR-18b-5p	gctGCACCTTAtcaggcca	0	UAAGGUGC	m8a	Created	no TS	-0.212000	-0.990000
hsa-miR-3161	gctgcacCTTATCAGgcca	2	CUGAUAAG	m8a	Created	0.021000	0.071000	-0.080000
hsa-miR-4502	gctgcaccTCATCAGgcca	1	GCUGAUGA	m7b	Disrupted	-0.014000	no TS	2.230000
hsa-miR-4735-3p	gctGCACCTTatcaggcca	0	AAAGGUGC	m7b	(m6c->m7b)	no TS	-0.233000	-3.510000
hsa-miR-18a-5p	gctGCACCTTAtcaggcca	0	UAAGGUGC	m8a	Created	no TS	-0.212	-1.16
hsa-miR-18b-5p	gctGCACCTTAtcaggcca	0	UAAGGUGC	m8a	Created	no TS	-0.212	-0.99
hsa-miR-3161	gctgcacCTTATCAGgcca	0	CUGAUAAG	m8a	Created	0.021	0.071	-0.08
hsa-miR-4502	gctgcaccTCATCAGgcca	0	GCUGAUGA	m7b	Disrupted	-0.014	no TS	2.23
hsa-miR-4735-3p	gctGCACCTTatcaggcca	0	AAAGGUGC	m7b	(m6c->m7b)	no TS	-0.233	-3.51

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.11461797C>T			COSN1471850		RK096_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1252	attcTCCTTCagctgttgc	8	AGAAGGAA	m6b	Disrupted	-0.047000	no TS	0.670000
hsa-miR-3173-3p	attCTCCTTTagctgttgc	0	AAAGGAGG	m7a	(m6b->m7a)	NA	NA	-0.310000
hsa-miR-4509	attctCCTTTAGctgttgc	0	ACUAAAGG	m7b	Created	no TS	-0.108000	-0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.11462024A>G			COSN6475665		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
11460625	rs141564741	-	ATATATATAT	hsa-miR-153-3p hsa-miR-3680-3p hsa-miR-448 hsa-miR-450b-5p hsa-miR-5011-5p hsa-miR-507 hsa-miR-557	5 5 5 6 8 6 6	atatatatatataTATGCAAaaaatatatat atatatatatatatATGCAAAAaatatatat atatatatatatATATGCAAaaaatatatat atatatatatatataTGCAAAAaatatatat atatatataTATATATgcaaaaaatatatat atatatatatatataTGCAAAAaatatatat atatatatatatataTGCAAAAaatatatat	Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N	-0.004 -0.006 -0.007 -0.004 -1.057 -0.004 -0.004
			-	hsa-miR-190a-3p	5	atatatgcaaaaaATATATAt	Unknown	N	0.954
11460625	rs143836539	-	ATAT	hsa-miR-153-3p hsa-miR-3680-3p hsa-miR-448 hsa-miR-450b-5p hsa-miR-5011-5p hsa-miR-507 hsa-miR-557	6 6 6 8 8 22 22	atatataTATGCAAaaaat atatatatATGCAAAAaat atatatATATGCAAaaaat atatatataTGCAAAAaat ataTATATATgcaaaaaat atatatataTGCAAAAaat atatatataTGCAAAAaat	Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N	-0.001 No Change -0.002 No Change -0.426 No Change No Change
			-	hsa-miR-129-5p	6	atatatGCAAAAAAt	Unknown	N	No Change
11460625	rs202065482	-	ATATATAT	hsa-miR-153-3p hsa-miR-3680-3p hsa-miR-448 hsa-miR-450b-5p hsa-miR-5011-5p hsa-miR-507 hsa-miR-557	5 5 5 6 8 6 6	atatatatataTATGCAAaaaatatat atatatatatatATGCAAAAaatatat atatatatatATATGCAAaaaatatat atatatatatataTGCAAAAaatatat atatataTATATATgcaaaaaatatat atatatatatataTGCAAAAaatatat atatatatatataTGCAAAAaatatat	Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N	-0.004 -0.004 -0.006 -0.002 -0.85 -0.002 -0.002
			-	hsa-miR-129-5p	8	atatatGCAAAAAAtatat	Unknown	N	0.002
11460627	rs61844556	T	T	hsa-miR-153-3p hsa-miR-190a-3p hsa-miR-448 hsa-miR-5011-5p	8 9 9 9	tatataTATGCAA tATATATAtgcaa tatatATATGCAA TATATATAtgcaa	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.174 -0.303 -0.415 -0.391
11460627	rs71511384	-	ATAT	hsa-miR-153-3p hsa-miR-190a-3p hsa-miR-448 hsa-miR-5011-5p	6 9 9 9	atatatataTATGCAAaaa atatATATATAtgcaaaaa atatatatATATGCAAaaa ataTATATATAtgcaaaaa	Unknown Unknown Unknown Unknown	N N N N	-0.001 -0.385 -0.002 -0.426
			-	hsa-miR-129-5p hsa-miR-3680-3p hsa-miR-450b-5p hsa-miR-507 hsa-miR-557	6 9 9 9 9	atatatatGCAAAAA atatatATGCAAAAa atatataTGCAAAAa atatataTGCAAAAa atatataTGCAAAAa	Unknown Unknown Unknown Unknown Unknown	N N N N N	No Change No Change No Change No Change No Change
11460628	rs71378794	-	TATA	hsa-miR-190a-3p hsa-miR-448 hsa-miR-5011-5p	11 14 11	tatATATATAtatgcaaaa tatatatatATATGCAAaa taTATATATAtatgcaaaa	Unknown Unknown Unknown	N N N	-0.385 -0.002 -0.426
			-	hsa-miR-153-3p hsa-miR-3680-3p hsa-miR-450b-5p hsa-miR-507 hsa-miR-557	8 12 12 12 12	tatataTATGCAAaa tatatatATGCAAAA tatatataTGCAAAA tatatataTGCAAAA tatatataTGCAAAA	Unknown Unknown Unknown Unknown Unknown	N N N N N	0.001 No Change No Change No Change No Change
11460651	rs199614121	-	TTATAT	hsa-miR-190a-3p hsa-miR-410-3p hsa-miR-5011-5p	0	agatttttATATATAtatatata agatttTTATATAtatatatata agattttTATATATAtatatata	Unknown Unknown Unknown	N N N	-0.413 -0.008 -0.466
			-
11460655	rs3057294	-	-	hsa-miR-3163 hsa-miR-410-3p hsa-miR-5011-5p hsa-miR-548c-3p	0	gtagatTTTTATAtatata gtagatttTTATATAtata gtagattttTATATATAta gtaGATTTTTAtatatata	Unknown Unknown Unknown Unknown	N N N N	0.001 -0.001 0.433 0.001
			TATA
11460656	rs202196510	T	T	hsa-miR-3163 hsa-miR-410-3p hsa-miR-548c-3p	0	agatTTTTATAta agatttTTATATA aGATTTTTAtata	Disrupted Disrupted Disrupted	N N N	0.017 -0.009 -0.147
			A	hsa-miR-190a-3p hsa-miR-5011-5p	0	agatttATATATA agattTATATATA	Created Created	N N	-0.161 -0.172

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