SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_015542
Gene Symbol:	UPF2
Description:	Homo sapiens UPF2 regulator of nonsense transcripts homolog (yeast) (UPF2), transcript variant 2, mRNA.
Gene Location:	chr10(-):11962020-12084808
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.11921140A>C			COSN521118		TCGA-BH-A0EB-01		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-138-5p	ggcagaaaCACCAGCctct	11	AGCUGGUG	m7b	Disrupted	-0.480000	-0.287000	0.040000
hsa-miR-193b-5p	ggcagAAACCCCagcctct	0	CGGGGUUU	m7b	Created	no TS	-0.217000	-0.010000
hsa-miR-3170	ggcagaAACCCCAGcctct	0	CUGGGGUU	m8a	Created	no TS	-0.112000	-1.290000
hsa-miR-4505	ggcagaaacCCCAGCCTct	0	AGGCUGGG	m8a	(m7a->m8a)	no TS	-0.151000	-0.050000
hsa-miR-4694-5p	ggcagaAACACCagcctct	10	AGGUGUUA	m6b	Disrupted	-0.074000	no TS	1.810000
hsa-miR-4731-5p	ggcagaaaCCCCAGCctct	0	UGCUGGGG	m7b	Created	no TS	-0.212000	No effect
hsa-miR-138-5p	ggcagaaaCACCAGCctct	11	AGCUGGUG	m7b	Disrupted	-0.480000	-0.287000	0.040000
hsa-miR-193b-5p	ggcagAAACCCCagcctct	0	CGGGGUUU	m7b	Created	no TS	-0.217000	-0.010000
hsa-miR-3170	ggcagaAACCCCAGcctct	0	CUGGGGUU	m8a	Created	no TS	-0.112000	-1.290000
hsa-miR-4505	ggcagaaacCCCAGCCTct	0	AGGCUGGG	m8a	(m7a->m8a)	no TS	-0.151000	-0.050000
hsa-miR-4694-5p	ggcagaAACACCagcctct	10	AGGUGUUA	m6b	Disrupted	-0.074000	no TS	1.810000
hsa-miR-4731-5p	ggcagaaaCCCCAGCctct	0	UGCUGGGG	m7b	Created	no TS	-0.212000	No effect
hsa-miR-138-5p	ggcagaaaCACCAGCctct	11	AGCUGGUG	m7b	Disrupted	-0.480000	-0.287000	0.040000
hsa-miR-193b-5p	ggcagAAACCCCagcctct	0	CGGGGUUU	m7b	Created	no TS	-0.217000	-0.010000
hsa-miR-3170	ggcagaAACCCCAGcctct	0	CUGGGGUU	m8a	Created	no TS	-0.112000	-1.290000
hsa-miR-4505	ggcagaaacCCCAGCCTct	0	AGGCUGGG	m8a	(m7a->m8a)	no TS	-0.151000	-0.050000
hsa-miR-4694-5p	ggcagaAACACCagcctct	10	AGGUGUUA	m6b	Disrupted	-0.074000	no TS	1.810000
hsa-miR-4731-5p	ggcagaaaCCCCAGCctct	0	UGCUGGGG	m7b	Created	no TS	-0.212000	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
11921138	rs61846677	C	C	hsa-miR-138-5p hsa-miR-4694-5p hsa-miR-485-5p hsa-miR-6884-5p hsa-miR-7978	11 10 19 19 11	aaaCACCAGCctc aAACACCAgcctc aaacacCAGCCTC aaacacCAGCCTC aaACACCAGcctc	Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N	-0.193 -0.074 -0.124 -0.124 -0.134
			A	hsa-miR-3188 hsa-miR-581	19 11	aaacacAAGCCTC aaACACAAGcctc	Created Created	N N	-0.108 -0.101

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