SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000372
Gene Symbol: TYR
Description: Homo sapiens tyrosinase (oculocutaneous albinism IA) (TYR), mRNA.
Gene Location: chr11(+):88911039-89028927
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr11:g.89295410C>A COSN8584873 3844_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5586-3p gaccTCACTCTaactcaaa
 4
 CAGAGUGA m7b Disrupted -0.304000 no TS 4.470000
hsa-miR-921 gacCTCACTAtaactcaaa
 0 CUAGUGAG m7b (m6b->m7b) no TS -0.194000 -3.370000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.89295526C>T COSN15172633 LP6005334-DNA_A04 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-124-5p caggtaGAACACacctgtc
 3
 CGUGUUCA m6b Disrupted -0.090000 no TS 3.630000
hsa-miR-223-5p caggtagAATACACctgtc
 0 CGUGUAUU m7b Created no TS -0.102000 -8.500000
hsa-miR-3650 caggtagaACACACCTgtc
 2
 AGGUGUGU m8a Disrupted -0.240000 no TS 2.870000
hsa-miR-4273 caggtAGAACACacctgtc
 0 GUGUUCUC m7a Disrupted NA NA 0.010000
hsa-miR-630 caggtAGAATACacctgtc
 0 AGUAUUCU m7b Created no TS -0.237000 -3.750000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.89295741T>A COSN15499953 AOCS-135-8-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4477a ttattTTAATAaaacagtg
 7
 CUAUUAAG m6b Disrupted 0.001000 no TS -0.330000
hsa-miR-4477a ttattTTAATAaaacagtg
 7
 CUAUUAAG m6b Disrupted 0.001000 no TS -0.330000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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